Abstract
Epstein-Barr virus (EBV), a member of the herpes group of viruses, is the cause of heterophile-positive infectious mononucleosis, of most heterophile-negative cases, and of occasional cases of tonsillitis and pharyngitis in childhood. Rarely, it may involve the liver or central nervous system as primary manifestations. This virus is strongly implicated as having a causal relationship to African Burkitt lymphoma and to nasopharyngeal cancer. High antibody titers are also present in 30–40% of cases of Hodgkin’s disease, in some patients with sarcoidosis, and in systemic lupus erythematosus.
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References
Armstrong, D., Henle, G., and Henle, W., Complement-fixation tests with cell lines derived from Burkitt’s lymphoma and acute leukemias, J. Bacteriol. 91:1257–1262 (1966).
Armstrong, J. A., Evans, A. S., Rao, N., and Ho, M., Viral infections in renal transplant recipients, Infect. Immun. 14:970–975 (1976).
Bailey, G. H., and Raffel, S., Hemolytic antibodies for sheep and ox erythrocytes in infectious mononucleosis, J. Clin. Invest. 14:228–244 (1935).
Banatvala, J. E., Best, J. M., and Waller, D. K., Epstein-Barr virus-specific IgM in infectious mononucleosis, Burkitt lymphoma, and nasopharyngeal carcinoma, Lancet 1:1205–1208 (1972).
Bang, J., Forsoeg paa at overfoere mononucleosis infectiosa til mennesket, Ugeshkr. Laeg. 105:499–504 (1943).
Bar, R. S., DeLor, J., Clausen, K. P., Hurtubise, P., Henle, W., and Hewetson, J. F., Fatal infectious mononucleosis in a family, N. Engl. J. Med. 290:363–367 (1974).
Barondess, J. A., and Erle, H., Serum alkaline phosphatase activity in hepatitis of infectious mononucleosis, Am. J. Med. 29:43–54 (1960).
Bauscher, J. C., and Smith, R. T., Studies of Epstein-Barr virus-host-relationship: Autochthonous and allogeneic lymphocyte stimulation by lymphoblast cell lines in mixed cell culture, Clin. Immunol. Immunopathol. 1:270–281 (1973).
Bender, C. E., Interpretation of hematologic and serologic findings in the diagnosis of infectious mononucleosis, Ann. Intern. Med. 49:852–865 (1958).
Bender, E. C., Recurrent mononucleosis, J. Am. Med. Assoc. 182:954–956 (1962).
Bentzon, J. W., The effect of certain infectious diseases on tuberculin allergy, Tubercle 34:34–41 (1953).
Biggar, R. J., Henle, W., Fleischer, G., Bocker, J., Lennette, E. T., and Henle, G., Primary Epstein-Barr virus infections in African infants. I. Decline of maternal antibodies and time of infection, Int. J. Cancer 22:239–243 (1978).
Biggar, R. J., Henle, G., Bocker, J., Lennette, E. T., Fleischer, G., and Henle, W., Primary Epstein-Barr virus infections in African infants. II. Clinical and serological observations during seroconversion, Int. J. Cancer 22:244–250 (1978).
Black, F. L., Hierholzer, W. J., Pinheiro, DeP., Evans, A. S., Woodall, J. P., Opton, E. M., Emmons, J. E., West, B. S., Edsall, G., Downs, W. G., and Wallace, G. D., Evidence for persistence of infectious agents in isolated human populations, Am. J. Epidemiol. 100:230–250 (1974).
Bloedorn, W. A., and Houghton, J. E., The occurrence of abnormal leucocytes in the blood in acute infections, Arch. Intern. Med. 27:315–325 (1921).
Boon, W. H., Mui, C. L. Y., and Too, M., Infectious mononucleosis in Singapore, J. Singapore Pediatr. Soc. 19:153–161 (1977).
Brown, J. W., Clifford, J. E., Sims, J. L., and White, E., Liver function during infectious mononucleosis, Am. J. Med. 6:321–328 (1949).
Cabot, R. C., The lymphocytosis of infection, Am. J. Med. Sci. 145:335–339 (1913).
Carlson, G. W., Brooks, E. H., and Marshall, V., Acute glandular fever: Recent epidemic, report of cases, Wis. Med. J. 25:176–178 (1926).
Carter, R. L., and Penman, H. G., The early history of infectious mononucleosis and its relation to”glandular fever,” in: Infectious Mononucleosis (R. L. Carter and H. G. Penman, eds.), Blackwell, Oxford, 1969.
Carvalho, R. P. S., Evans, A. S., Frost, P., Dalldorf, G., Camargo, M. E., and Jarma, M., EBV infection in Brazil. I. Occurrence in normal persons, in lymphomas and in leukemias, Int. J. Cancer 11:191–201 (1973).
Center for Disease Control, Infectious Mononucleosis Surveillance, November 1972.
Chang, R. S., and Golden, H. D., Transformation of human leucocytes by throat washings from infectious mononucleosis patients, Nature (London) 234:359–360 (1971).
Chang, R. S., Lewis, J. P., and Abildgaard, C. F., Excretors of leucocyte-transforming agents among a human population, N. Engl. J. Med. 289:1328–1329 (1973)
Christine, B. W., Infectious mononucleosis, Conn. Health Bull. 82:115–119 (1968).
Connecticut State Health Department, Personal communication.
Corey, L., Stamm, W. E., Feorino, P. M., Bryan, J. A., Weseley, S., Gregg, M. B., and Solangi, K., HBs AG-negative hepatitis in a hemodialysis unit: Relation to Epstein-Barr virus, N. Engl. J. Med. 293:1273–1278 (1975).
Cross, J. G., Conditions simulating an acute leukemia (acute benign leukemia), Minn. Med. 5:579–581 (1922).
Davidsohn, I., and Walker, P. H., The nature of the heterophilic antibodies in infectious mononucleosis, Am. J. Clin. Pathol. 5:455–465 (1935).
Davidsohn, I., Heterophile antibodies in serum sickness, J. Immunol. 16:259–273 (1929).
Davidsohn, R. J. L., A survey of infectious mononucleosis in the North-East Regional Hospital Board area of Scotland, 1960–9, J. Hyg. 68:393–400 (1970).
Diehl, V., Henle, G., Henle, W., and Kohn, G., Demonstration of a herpes group virus in cultures of peripheral leukocytes from patients with infectious mononucleosis, J. Virol. 2:663–669 (1968).
Dingle, J. H., Badger, G. F., and Jordan, W. S., Jr., Illness in the Home: A Study of 25,000 Illnesses in a Group of Cleveland Families, The Press of Western Reserve, Cleveland, 1964.
Downey, H., and McKinlay, C. A., Acute lymphadenosis compared with acute lymphatic leukemia, Arch. Intern. Med. 32:82–112 (1923).
Edwards, J. M. B., and McSwiggan, D. A., Studies on the diagnostic value of an immunofluorescence test for EB virus specific IgM, Clin. Pathol. 27:647–651 (1974)
Edwards, J. M. B., Vandervelde, E. M., Cohen, B. J., and McSwiggan, D. A., Laboratory diagnosis of EB virus infection in some cases presenting as hepatitis, J. Clin. Pathol. 31:179–182 (1978).
Ellenbogen, C., and Reinarz, J. A., The Epstein-Barr virus and its relationship to infectious mononucleosis in air force recruits, Mil. Med. 140:371–373 (1974).
Enberg, R. N., Eberle, B. J., and Williams, R. C., Peripheral blood T and B cells in infectious mononucleosis, J. Infect. Dis. 130:104–111 (1974).
Epstein, M. A., and Achong, B. G., Various forms of Epstein-Barr virus infection in man: Established facts and a general concept, Lancet 2:836–839 (1973).
Epstein, M. A., and Achong, B. G., Pathogenesis of infectious mononucleosis, Lancet 2:1270–1278 (1977).
Epstein, M. A., Achong, B. G., and Barr, Y. M., Virus particles in cultured lymphoblasts from Burkitt’s lymphoma, Lancet 1:702–703 (1964).
Evans, A. S., Experimental attempts to transmit infectious mononucleosis to man, Yale J. Biol. Med. 20:19–26 (1947).
Evans, A. S., Liver function tests in infectious mononucleosis, J. Clin. Invest. 27:106–110 (1948).
Evans, A. S., Further experimental attempts to transmit infectious mononucleosis to man, J. Clin. Invest. 29:508–512 (1950).
Evans, A. S., Infectious mononucleosis in University of Wisconsin students: Report of a five-year investigation, Am. J. Hyg. 71:342–362 (1960).
Evans, A. S., Infectious mononucleosis: Observations from a public health laboratory, Yale J. Biol. Med. 34:261–276 (1961/1962).
Evans, A. S., Complications of infectious mononucleosis: Recognition and management, Hosp. Med. 3:24–25, 28–33 (1967).
Evans, A. S., Infectious mononucleosis: Recent developments, Gen. Pract. 60:127–134 (1969).
Evans, A. S. Infectious mononucleosis in the armed forces, Mil. Med. 135:300–304 (1970).
Evans, A. S., New discoveries in infectious mononucleosis, Mod. Med. 1:18–24 (1974).
Evans, A. S., The history of infectious mononucleosis, Am. J. Med. Sci. 267:189–195 (1974).
Evans, A. S., Commentary—EB virus, infectious mononucleosis and cancer: The closing of the web, Yale J. Biol. Med. 47:113–122 (1974).
Evans, A. S., Infectious mononucleosis and related syndromes, Am. J. Med. Sci. 276:325–339 (1978).
Evans, A. S., and Robinton, E. D., An epidemiologic study of infectious mononucleosis in a New England college, N. Engl. J. Med. 242:492–496 (1950).
Evans, A. S., and Paul, J. R., Infectious mononucleosis, in: Preventive Medicine in World War II, Vol. V: Communicable Diseases (J. B. Coates, Jr., ed.), Office of the Surgeon General, Department of the Army, Washington, D.C., 1960.
Evans, A. S., and Campos, L. E., Acute respiratory diseases in students at the University of the Philippines, Bull. WHO 45:103–112 (1971).
Evans, A. S., Carvalho, R. P. S., and Grossman, L., EBV infections in Brazil. III. Infectious mononucleosis, Unpublished (1974).
Evans, A. S., Evans, B. K., and Sturtz, V., Standards for hepatic and hematologic tests in monkeys: Observations during experiments with hepatitis and mononucleosis, Proc. Soc. Exp. Biol. Med. 82:437–440 (1953).
Evans, A. S., Niederman, J. C, and McCollum, R. W., Seroepidemiological studies of infectious mononucleosis with EB virus, N. Engl. J. Med. 279:1121–1127 (1968).
Evans, A. S., Jensen, R., Niederman, J. C., and Wallace, D. K., Studies of EBV antibody in Fort Jackson military recruits, Unpublished data (1974).
Evans, A. S., Niederman, J. C., Cenabre, L. C., West, B., and Richards, V. A., A prospective evaluation of heterophile and Epstein-Barr virus-specific IgM antibody tests in clinical and subclinical infectious mononucleosis: Specificity and sensitivity of the tests and persistence of antibody, J. Infect. Dis. 132:546–554 (1975).
Filatov, N. F., Semiotik and Diagnotik de Kinderkran-kheiten, Verlag von Ferdinand Enke, Stuttgart, 1892.
Filatov, N. F., Lektuse ob ostrikh infektsion nikh lolieznyak (Lectures on acute infectious diseases of children), Moscow, U Deitel, 1885; cited by Wising, P. J., Acta Med. Scand. Suppl. 133:1–102 (1942).
Fleischer, G., Lennette, E. T., Henle, G., and Henle, W., Incidence of heterophile antibody responses in children with infectious mononucleosis, J. Pediatr. 94:723–728 (1979).
Gardner, H. T., and Paul, J. R., Infectious mononucleosis at the New Haven Hospital, 1921–46, Yale J. Biol. Med. 19:839–853 (1947).
Gerber, P., and Deal, D. R., Epstein-Barr virus-induced viral and soluble complement-fixing antigens in Burkitt lymphoma cell cultures, Proc. Soc. Exp. Biol. Med. 134:748–751 (1970).
Gerber, P., and Rosenblum, E. N., The incidence of complement-fixing antibodies to herpes simplex and herpes-like viruses in man and rhesus monkeys, Proc. Soc. Exp. Biol. Med. 128:541–546 (1968).
Gerber, P., Purcell, R. H., Rosenblum, E. N., and Walsh, J. H., Association of EB-virus infection with the post-perfusion syndrome, Lancet 1:593–596 (1969).
Gerber, R., Goldstein, L. I., Lucas, S., Nonoyama, M., and Perlin, E., Oral excretion of Epstein-Barr viruses by healthy subjects and patients with infectious mononucleosis, Lancet 2:988–989 (1972).
Gerber, P., Nkrumah, F. K., Pritchett, R., and Kieff, E., Comparative studies of Epstein-Barr virus strains from Ghana and the United States, Int. J. Cancer 17:71–81 (1976).
Ginsburg, C. M., Henle, W., Henle, G., and Horwitz, C. A., Infectious mononucleosis in children: Evaluation of Epstein-Barr virus specific serological data, J. Am. Med. Assoc. 237:781–785 (1977).
Ginsburg, C. M., Henle, G., and Henle, W., An outbreak of infectious mononucleosis among the personnel of an outpatient clinic, Am. J. Epidemiol. 104:571–575 (1976).
Giulano, V. J., Jasin, H. E., and Ziff, M., The nature of the atypical lymphocyte in infectious mononucleosis, Clin. Immunol. Immunopathol. 3:90–98 (1974).
Grace, J. T., Blakeslee, J., and Jones, R., Induction of infectious mononucleosis in man by the herpestype virus (HTV) in Burkitt lymphoma cells in tissue culture, Proc. Am. Assoc. Cancer Res. 10:31 (1969).
Grose, C., Henle, W., Henle, G., and Feorino, P. M., Primary Epstein-Barr infections in acute neurologic disease, N. Engl. J. Med. 292:392–393 (1975).
Haider, S., Coutinho, M. D., and Emond, R. T. D., Tuberculin anergy and infectious mononucleosis, Lancet 2:74 (1973).
Hainebach, J., II. Beitrag zur Aetiologie des Pfeiffer’schen Driisenfiebers, Dtsch. Med. Wochenschr. 26:419–420 (1899).
Halcrow, J. P. A., Owen, L. M., and Roger, N. O., Infectious mononucleosis with an account of an epidemic in E.M.S. hospital, Br. Med. J. 2:443–447 (1943).
Hallee, T. J., Evans, A. S., Niederman, J. C., Brooks, C. M., and Voegtly, J. H. Infectious mononucleosis at the U.S. Military Academy: A prospective study of a single class over four years, Yale J. Biol. Med. 47:182–195 (1974).
Hamilton, J. K., Sullivan, J. L., Maurer, H. S., Cruzi, F. G., Proirson, A. J., Stenke, K., Finkelstein, G. Z., Landing, B., Grunnet, M., and Purtilo, D. T., X-linked lymphoproliferative syndrome registry report, J. Pediatr. 4:669–673 (1980).
Hampar, B., Hsu, K. C., Martos, L. M., and Walker, J. L., Serologic evidence that a herpes-type virus is the etiologic agent of heterophile-positive infectious mononucleosis, Proc. Natl. Acad. Sci. U.S.A. 68:1407–1411 (1971).
Hardy, D. A., and Steel, C. M., Cytotoxic potential of lymphocytes stimulated with autochthonous lymphoid cell lines, Experientia 27:1336–1338 (1971).
Heath, C. W., Brodsky, A. L., and Potolsky, A. I., Infectious mononucleosis in a general population, Am. J. Epidemiol. 95:46–52 (1972).
Haynes, B. F., Schooley, R. T., Playing-Wright, C. R., Grouse, J. E., Dolin, R., and Fauci, A. S. Emergence of suppressor cells of immunoglobulin synthesis during acute Epstein-Barr-virus-induced infectious mononucleosis, J. Immunol. 123:2095–2101 (1979).
Haynes, B. F., Schooley, R. T., Grouse, J. E., Playing-Wright, C. R., Dolin, R., and Fauci, A. S., Characterization of thymus-derived lymphocyte subsets in acute Epstein-Barr virus induced infectious mononucleosis, J. Immunol. 122:699–702 (1979).
Henderson, E., Miller, G., Robinson, J., andHeston, L., Efficiency of transformation of lymphocytes by Epstein-Barr virus, Virology 76:152–163 (1977).
Henderson, E., Heston, L., Grogan, E., and Miller, G., Radiobiological inactivation of Epstein-Barr virus, J. Virol. 25:51–59 (1978).
Henke, C. E., Kurland, L. T., and Elveback, L. R., Infectious mononucleosis in Rochester, Minn., 1950 through 1969, Am. J. Epidemiol. 98:483–490 (1973).
Henle, G., and Henle, W., Immunofluorescence in cells derived from Burkitt7s lymphoma, J. Bacteriol. 91:1248–1256 (1966).
Henle, G., and Henle, W., Observations on childhood infections with Epstein-Barr virus, J. Infect. Dis. 121:303–310 (1970).
Henle, G., Henle, W., and Diehl, V., Relation of Burkitt’s tumor-associated herpes-type virus to infectious mononucleosis, Proc. Natl. Acad. Sci. U.S.A. 59:94–101 (1968).
Henle, G., Henle, W., and Horwitz, C. A., Antibodies to Epstein-Barr virus-associated nuclear antigen in infectious mononucleosis, J. Infect. Dis. 130:231–239 (1974).
Henle, W., Henle, G., and Horwitz, C. A., Epstein-Barr virus specific diagnostic tests in infectious mononucleosis, Hum. Pathol. 5:551–565 (1974).
Henle, G., Henle, W., and Klein, G., Demonstration of two distinct components in the early antigen complex of Epstein-Barr virus-infected cells, Int. J. Cancer 8:272–282 (1971).
Henle, W., Henle, G., Harrison, F. S., Joyner, C. R., Klemola, E., Paloheimo, J., Scriba, M., and von Essen, F., Antibody responses to the Epstein-Barr virus and cytomegaloviruses after open-heart and other surgery, N. Engl. J. Med. 282:1068–1074 (1968).
Henle, W., Henle, G., Pearson, G., Scriba, M., Waubke, R., and Zajac, B. A., Differential reactivity of human serums with early antigens induced by Epstein-Barr virus, Science 169:188–190 (1970).
Henle, W., Henle, G., Niederman, J. C, Haltia, K., and Klemola, E., Antibodies to early antigens induced by Epstein-Barr virus in infectious mononucleosis, J. Infect. Dis. 124:58–67 (1971).
Hewetson, J. F., Rochi, G., Henle, W., and Henle, G., Neutralizing antibodies to Epstein-Barr virus in healthy populations and patients with infectious mononucleosis, J. Infect. Dis. 128:283–389 (1973).
Hoagland, R. J., The transmission of infectious mononucleosis, Am. J. Med. Sci. 229:262–272 (1955).
Hoagland, R. J., Resurgent heterophil-antibody reaction after infectious mononucleosis, N. Engl. J. Med. 269:1307–1308 (1963).
Hoagland, R. J., The incubation period of infectious mononucleosis, Am. J. Public Health 54:1699–1705 (1964).
Hoagland, R., Infectious Mononucleosis, Grune and Stratton, New York, 1967.
Hobson, F. G., Lawson, B., and Wigfield, M., Glandular fever, a field study, Br. Med. J. 1:845–852 (1958).
Hoskins, T. W., Fletcher, W. B., Blake, J. M., Pereira, M. S., and Edwards, J. M. B., EB virus antibody and infectious mononucleosis in a boarding school for boys, J. Clin. Pathol. 29:42–45 (1976).
Hun, L. M., Huang, Y. T., Dascomb, H. E., and Pagano, J. S., Enhanced destruction of lymphoid cell lines by peripheral blood leucocytes taken from patients with acute infectious mononucleosis, J. Immunol. 115:243–248 (1975).
Jennings, E., Prevalence of EB virus antibody in Hawaii, M.D. thesis, Yale University School of Medicine, 1973.
Joncas, J., and Mitnyan, C., Serological response of the EBV antibodies in pediatric cases of infectious mononucleosis and in their contacts, Can. Med. Assoc. J. 102:1260–1263 (1970).
Jondal, M., and Klein, G., Surface markers on human B and T lymphocytes. II. Presence of Epstein-Barr virus receptors on B lymphocytes, J. Exp. Med. 138:1365–1378 (1973).
Jondal, M., Klein, G., Oldstone, M. B. S., Bokish, V., and Yefenof, E., Surface markers on human B and T lymphocytes. VII. Association between complement and Epstein-Barr virus receptors on human lymphoid lines, Scand. J. Immunol. 5:401–410 (1976).
Jordan, W. S., and Albright, R. W., Liver function tests in infectious mononucleosis, J. Lab. Clin. Med. 35:688–698 (1950).
Junge, U., Deinhardt, F., and Hoekstra, J., Stimulation of peripheral lymphocytes by allogeneic and autochthonous mononucleosis lymphocyte cell lines, J. Immunol. 106:1306–1315 (1971).
Kano, K., and Milgrom, F., Heterophile antigens and antibodies in medicine, Current Top. Microbiol. Immunol. 77:43–69 (1977).
Klein, G., Klein, E., Clifford, P., and Sternsward, G., Search for tumor specific immune reactors in Burkitt lymphoma patients by the membrane immunofluorescence reaction, Proc. Natl. Acad. Sci. U.S.A. 55:1628–1635 (1966).
Kassl, S. V., Evans, A. S., and Niederman, J. C. Psychosocial risk factors in the development of infectious mononucleosis, Psychosom. Med. 41:445–466, 1979.
Klein, G., Lindahl, T., Jondal, M., Leibolb, W., Menézes, J., Nilsson, K., and Sundstrôm, C., Continuous lymphoid cell lines with characteristics of B cells (bone-marrow-derived) lacking the Epstein-Barr virus genome, and derived from three human lymphomas, Proc. Natl. Acad. Sci. U.S.A. 71:3283–3286, (1974).
Klein, G., Diehl, V., Henle, G., Henle, W., Pearson, G., and Neiderman, J. C., Relations between Epstein-Barr viral and cell membrane immunofluorescence in Burkitt tumor cells. II. Comparison of cells and sera from patients with Burkitt’s lymphoma and infectious mononucleosis, J. Exp. Med. 128:1021–1030 (1968).
Klein, G., Svedmvy, E., Jondal, M., and Persson, P. O., EBV-determined nuclear antigen (EBNA)-positive cells in the peripheral blood of infectious mononucleosis patients, Int. J. Cancer 17:21–26 (1976).
Klemola, E., Henle, G., Henle, W., and von Essen, R., Infectious mononucleosis-like disease with negative heterophile agglutination test: Clinical features in relation to Epstein-Barr virus and cytomegalovirus antibodies, J. Infect. Dis. 121:608–614 (1970).
Lang, D. J., and Hanshaw, J. B., Cytomegalovirus infection and the postperfusion syndrome: Recognition of primary infection in four patients, N. Engl. J. Med. 280:1145–1149 (1969).
Lee, C. L., Davidsohn, I., and Slaby, R., Horse agglutinins in infectious mononucleosis. Am. J. Clin. Pathol. 49:3–11 (1968).
Lehane, D. E., A seroepidemiologic study of infectious mononucleosis: The development of EB virus antibody in a military population, J. Am. Med. Assoc. 212:2240–2242 (1970).
Lemon, S. M., Hutt, L. M., Shaw, J. C., Li, J. H., and Pagano, J. H., Replication of EBV in epithelial cells during infectious mononucleosis, Nature (London) 268:268–270 (1977).
Lemon, S. M., Hutt, L. M., Huang, Y., Blum, J., and Pagano, J. H., Simultaneous infection with multiple herpesviruses, Am. J. Med. 66:270–276 (1979).
Lennette, E. T., Henle, G., Henle, W., and Horowitz, C. A., Heterophil antigen in bovine sera detectable by immune adherence hemagglutination with infectious mononucleosis sera, Infect. Immun. 19:923–927 (1978).
Liebowitz, S., Infectious Mononucleosis, Grune and Stratton, New York, 1953.
Longcope, W. T., Infectious mononucleosis (glandular fever), with a report of ten cases, Am. J. Med. Sci. 164:781–807 (1922).
Mangi, R., Niederman, J. C., Kelleher, J. E., Dwyer, J. M., Evans, A. S., and Kantor, F. S., Depression of cell-mediated immunity during acute infectious mononucleosis, N. Engl. J. Med. 291:1149–1153 (1974).
Mason, K. L., An ox cell hemolysin test for the diagnosis of infectious mononucleosis, J. Hyg. 49:471–481 (1951).
Maurer, B. A., Imamura, T., and Wilbert, S. M., Incidence of EB virus containing cells in primary and secondary clones of several Burkitt lymphoma cell lines, Cancer Res. 30:2870–2875 (1970).
Miller, G., The oncogenicity of Epstein-Barr virus, J. Infect. Dis. 130:187–205 (1974).
Miller, G., Biology of Epstein-Barr virus, in: Viral Oncology (G. Klein, ed.), pp. 713–738, Raven Press, New York, 1980.
Miller, G., and Heston, L., Expression of Epstein-Barr viral capsid, complement fixing and nuclear antigens in stationary and exponential phase cultures, Yale J. Biol. Med. 47:123–135 (1974).
Miller, G., and Lipman, M., Release of infectious Epstein-Barr virus by transformed marmoset leucocytes, Proc. Natl. Acad. Sci. U.S.A. 70:190–194 (1973).
Miller, G., Niederman, J. C., and Andrews, L. L., Prolonged oropharyngeal excretion of Epstein-Barr virus after infectious mononucleosis, N. Engl. J. Med. 288:229–232 (1973).
Miller, G., Miller, M. H., and Sttit, D., Epstein-Barr viral antigen in single cell clones of two human leucocytic lines, J. Virol. 6:699–701 (1970).
Miller, G., Niederman, J. C., and Suit, D. A., Infectious mononucleosis: Appearance of neutralizing antibody to Epstein-Barr virus measured by inhibition of formation of lymphoblastoid cell lines, J. Infect. Dis. 125:403–406 (1972).
Miller, G., Robinson, J., Heston, L., and Lipman, M., Differences between laboratory strains of Epstein-Barr virus based on immortalization, abortive infection and interference, Proc. Natl. Acad. Sci. U.S.A. 71:4006–4010 (1974).
Moir, J. I., Glandular fever in the Falkland Islands, Br. Med. J. 2:822–823 (1930).
Mori, T., Kano, K., and Milgrom, F., Formation of Paul Bunnell antibodies by cultures of lymphocytes from infectious mononucleosis, Cell. Immunol. 34:289–298 (1977).
Morgan, D. G., Niederman, J. C., Miller, G., Smith, H. W., and Dowaliby, J. M., Site of Epstein-Barr virus replication in the oropharynx, Lancet 2:1154–1157 (1979).
Morse, P. F., Glandular fever, J. Am. Med. Assoc. 77:1403–1404 (1921).
Munoz, N., Davidson, R. J. K., Witthoff, B., Ericsson, J. E., and de The, G., Infectious mononucleosis and Hodgkin’s disease, Int. J. Cancer 22:10–13 (1978).
Newall, K. W., The reported incidence of glandular fever, and analysis of a report of the Public Health Laboratory Service, J. Clin. Pathol. 10:20–22 (1957).
Niederman, J. C., Infectious mononucleosis at the Yale-New Haven Medical Center, 1946–1955, Yale J. Biol. Med. 28:629–643 (1956).
Niederman, J. C., The presence of EBV antibody in sera from volunteers in infectious mononucleosis transmission attempts prior to inoculation, Unpublished work (1969).
Niederman, J. C., and Scott, R. B., Studies on infectious mononucleosis: Attempts to transmit the disease to human volunteers, Yale J. Biol. Med. 38:1–10 (1965).
Niederman, J. C., Evans, A. S., McCollum, R. W., and Subrahmanyan, L., Prevalence, incidence and persistence of EB virus antibody in young adults, N. Engl. J. Med. 282:361–365 (1970).
Niederman, J. C., McCollum, R. W., Henle, G., and Henle, W., Infectious mononucleosis: Clinical manifestations in relation to EB virus antibodies, J. Am. Med. Assoc. 203:205–209 (1968).
Niederman, J. C., Miller, G., Pearson, H. A., Pagano, J. S., and Dowaliby, J. M., Infectious mononucleosis: Epstein-Barr shedding in saliva and the oropharynx, N. Engl. J. Med. 294:1355–1359 (1976).
Nikoskelainen, J., Leikola, J., and Klemola, E., IgM antibodies specific for Epstein-Barr virus in infectious mononucleosis without heterophile antibodies, Br. Med. J. 4:72–75 (1974).
Nikoskelainen, J. J., Ablashi, D. V., Isenberg, R. Neel, E. U., Miller, R. G., and Stevens, D. A., Cellular immunity in infectious mononucleosis. II. Specific reactivity to Epstein-Barr virus antigens and correlation with clinical and hematologic parameter, J. Immunol. 121:1239–1244 (1978).
Nonoyama, M., and Pagano, J. S., Homology between Epstein-Barr virus DNA and viral DNA from Burkitt7s lymphoma and nasopharyngeal carcinoma determined by DNA-DNA reassociation kinetics, Nature (London) 242:44–47 (1973).
Old, L. J., Clifford, P., Boyse, E. A., DeHarven, E., Geering, G., Oettgen, H. F., and Williamson, Precipitating antibody in human serum to an antigen present in cultured Burkitt lymphoma cells, Proc. Natl. Acad. Sci. U.S.A. 56:1699–1704 (1966).
Pagano, J. S., The Epstein-Barr viral genome and its interactions with human lymphoblastoid cells and chromosomes, in: Viruses, Evolution and Cancer (K. Maramorosch and E. Kurstak, eds.), 79–116, Academic Press, New York, 1974.
Pannuti, C. S., Carvalho, R. P. S., Evans, A. S., Cenabre, L. C, Neto, A., Camargo, M., Angelo, M. J. P., and Takimoto, S., A prospective clinical study of the mononucleosis syndrome in a developing country, Int. J. Epidemiol. 9:349–353 (1980).
Pattengale, P. K., Gerber, P., and Smith, R. W., Selective transformation of B lymphocytes by EB virus, Lancet 2:1153–1155 (1973).
Pattengale, P. K., Gerber, P., and Smith, R. W., B-cell characteristics of human peripheral and cord blood lymphocytes transformed by Epstein-Barr virus, J. Natl. Cancer Inst. 52:1081–1086 (1974).
Pattengale, P. K., Smith, R. W., and Perlin, E., Atypical lymphocytes in acute infectious mononucleosis, N. Engl. J. Med. 291:1145–1148 (1974).
Paul, J. R., and Bunnell, W. W., The presence of heterophile antibodies in infectious mononucleosis, Am. J. Med. Sci. 183:91–104 (1932).
Paul, O., Mononucleosis on board a destroyer, U.S. Naval Med. Bull. 44:614–617 (1945).
Pearson, G., Dewey, F., Klein, G., Henle, G., and Henle, W., Relation between neutralization of Epstein-Barr virus and antibodies to cell membrane antigens induced by the virus, J. Natl. Cancer Inst. 45:989–995 (1970).
Pereira, M. S., Blake, J. M., and Macrae, A. D., EB virus antibody at different ages, Br. Med. J. 4:526–527 (1969).
Pereira, M. S., Field, A. M., Blake, J. M., Rodgers, F. G., Bailey, L. A., and Davies, J. R., Evidence for oral excretion of E.B. virus in infectious mononucleosis, Lancet 1:710–711 (1972).
Pfeiffer, E., Drusenfieber, Jahrb. Kinderheilkd. 29:257–264 (1889).
Pope, J. H., Horne, M. K., and Wetters, E. J., Significance of a complement-fixing antigen associated with herpes-like virus and detected in the Raji cell line, Nature (London) 228:186–187 (1969).
Pulvertaft, R. J. X., Cytology of Burkitt’s tumor (African lymphoma), Lancet 1:238–240 (1964).
Purtilo, D. T., Bhawan, J., Hutt, L. M., DeNicola, L., Szymanski, I., Yang, J. P. S., Boto, W., Maier, R., and Thorley-Lawson, D., Epstein-Barr virus infections in the X-linked recessive lymphoproliferative syndrome, Lancet 1:798–801 (1978).
Purtilo, D. T., Hutt, L, Bhawan, J., Yang, J. P. S., Cassel, C., Allegro, S., and Rosen, F. S., Immunodeficiency to the Epstein-Barr virus in the X-linked recessive lymphoproliferative syndrome, Clin. Immunol. Immunopathol. 9:147–156 (1978).
Qualtiere, L. F., and Pearson, G. R., Solubilization of Epstein-Barr virus induced membrane antigen by limited papain digestion, Fed. Proc. Fed. Am. Soc. Exp. Biol. 37:1817 (1978).
Reedman, B. M., and Klein, G., Cellular localization of an Epstein-Barr virus (EBV) associated complement-fixing antigen in producer and non-producer lymphoblastoid cell lines, Int. J. Cancer 11:499–520 (1973).
Robinson, J., and Miller, G., Assay for Epstein-Barr virus based on stimulation of DNA synthesis in mixed leukocytes from human umbilical cord blood, J. Virol. 15:1065–1072 (1975).
Robinson, J. E., Brown, N., Andiman, W., Halliday, K., Francke, U., Robert, M. F., Andersson-Anvret, M., Horstmann, D., and Miller, G., Diffuse polyclonal B-cell lymphoma during primary infection with Epstein-Barr virus, New Engl. J. Med. 320:1293–1296 (1980).
Rocchi, G., Hewetson, J., and Henle, W., Specific neutralizing antibodies in Epstein-Barr virus associated diseases, Int. J. Cancer 11:637–647 (1973).
Rocchi, G., deFelici, A., Ragona, G., and Heinz, A., Quantitative evaluation of Epstein-Barr-virus-infected mononuclear peripheral blood leukocytes in infectious mononucleosis, N. Engl. J. Med. 296:132–134 (1977).
Rosalki, S. B., Lwynn, J. T., and Verney, P. T., Transaminase and liver function studies in infectious mononucleosis, Br. Med. J. 1:929–932 (1960).
Rosdahl, N., Larsen, S. O., and Thamdrup, B., Infectious mononucleosis in Denmark: Epidemiological observations based on positive Paul-Bunnell reactions 1940–1969, Scand. J. Infect. Dis. 5:163–170 (1973).
Rosen, A., Gergely, P., Jondal, M., and Klein, G., Polyclonal Ig production after Epstein Barr virus infection of human lymphocytes in vitro, Nature (London) 267:52 (1977).
Royston, I., Sullivan, J. L., Periman, P. O., and Perlin, E., Cell-mediated immunity to Epstein-Barr virus-transformed lymphoblastoid cells in acute infectious mononucleosis, N. Engl. J. Med. 293:1159–1163 (1975).
Sawyer, R. N., Evans, A. S., Niederman, J. C., and McCollum, R. W., Prospective studies of a group of Yale University freshmen. I. Occurrence of infectious mononucleosis, J. Infect. Dis. 123:263–269 (1971).
Schiff, J., Schaeffer, J., and Robinson, J., Cell-associated Epstein-Barr virus in the cerebrospinal fluid of a patient with meningoencephalitis complicating infectious mononucleosis, Personal communication (1978).
Schiller, J., and Davey, F. R., Human leukocyte locus A (HL-A antigens and infectious mononucleosis, Am. J. Clin. Pathol. 62:325–328 (1974).
Schmitz, H., and Scherer, M., IgM antibodies to Epstein-Barr virus in infectious mononucleosis, Arch. Gesamte Virusforsch. 37:332–339 (1972).
Sheldon, P. J., Hemsted, E. H., Holborow, E. J., and Papamichael, M., Thymic origin of atypical lymphocytes in infectious mononucleosis, Lancet 2:1153–1155 (1973).
Shope, T., and Miller, G., Epstein-Barr virus, heterophile responses in squirrel monkeys inoculated with virus-transformed autologous leucocytes, J. Exp. Med. 137:140–147 (1973).
Shope, T., Evans, A. S., and Horstmann, D. M., Seroconversion rates of EBV antibody in New Haven school children by socio-economic level, Unpublished studies (1973).
Smith, H., and Denman, A. M., A new manifestation of infection with Epstein-Barr virus, Br. Med. J. 2:248–249 (1978).
Sohier, R., Lepine, P., and Sautter, V., Recherches sur la transmission experimentale de la mononucleose au singe et a Thomme, Ann. Inst. Pasteur 65:50–62 (1940).
Sohier, R., La Mononucleose Infectieuse, Masson et Cie, Paris, 1943.
Sprunt, T. P., and Evans, F. A., Mononuclear leukocytosis in reaction to acute infections (in infectious mononucleosis), Bull. Johns Hopkins Hosp. 31:410–417 (1920).
Steel, C. M., and Ling, N. R., Immunopathology of infectious mononucleosis, Lancet 2:861–862 (1973).
Stevenson, E. M. K., and Brown, T. G., Infectious mononucleosis: Preliminary investigation of a series of cases, Glasgow Med. J. 140:139–150 (1943).
Storrie, M. D., Sawyer, R. N., Sphar, R. L., and Evans, A. S., Seroepidemiological studies of Polaris submarine crews. II. Infectious mononucleosis, Mil. Med. 141:30–33 (1976).
Strauch, B., Andrews, L., Miller, G., and Siegel, N., Oropharyngeal excretion of Epstein-Barr virus by renal transplant recipients and other patients treated with immunosuppressant drugs, Lancet 1:234–237 (1974).
Strom, J., Infectious mononucleosis—Is the incidence increasing?, Acta Med. Scand. 168:35–39 (1960).
Sumaya, C. V., Primary Epstein-Barr virus infections in children, Pediatrics 59:16–21 (1977).
Taylor, A. W., Effects of glandular fever in acute leukemia, Br. Med. J. 1:589–593 (1953).
Thomsen, S., Studier over Mononucleosis Infectiosa, Munksgaard, Copenhagen, 1942.
Thorley-Lawson, D. A., Chess, L., and Strominger, J. L., Suppression of in vitro Epstein-Barr virus infection: A new role for adult human T lymphocytes, J. Exp. Med. 146:495–507 (1977).
Tischendorf, P., Balagtas, R. C., Deinhardt, F., Knospe, W. H., Maynard, J. E., Noble, G. R., and Shramek, G. J., Development and persistence of immunity to Epstein-Barr virus in man, J. Infect. Dis. 122:401–409 (1970).
Tosato, G., Magrath, I., Koski, I., Dooley, N., and Blaese, M., Activation of suppressor T cells during Epstein-Barr-virus induced infectious mononucleosis, N. Engl. J. Med. 301:1133–1137 (1979).
University Health Physicians and P.H.L.S. Laboratories, A joint investigation: Infectious mononucleosis and its relationship to EB virus antibody, Br. Med. J. 4:643–646 (1971).
Vandermeer, R., Lutterloh, C. H., and Pilot, J., Infectious mononucleosis: An analysis of 26 clinical and 340 subclinical cases, Am. J. Med. Sci. 210:765–774 (1945).
Veltri, R. W., McClung, J. E., and Sprinkle, P. M., EBV antigens in lymphocytes of patients with exudative tonsillitis, infectious mononucleosis and Hodgkin7s disease, Int. J. Cancer 21:683–687 (1978).
Veltri, R. W., McClung, J. E., and Sprinkle, P. M., Epstein-Barr nuclear antigen (EBNA) carrying lymphocytes in human palatine tonsils, J. Gen. Virol. 32:455–460 (1976).
Visintine, A. M., Gerber, P., and Nahmias, A. J., Leucocyte transforming agent (Epstein-Barr virus) in newborn infants and older individuals, J. Pediatr. 89:571–575 (1976).
Virolainen, M., Anderson, L. C, Lalla, M., and von Essen, R., T-lymphocyte proliferation in mononucleosis, Clin. Immunol. Immunopathol. 2:114–120 (1973).
Wahren, B., Espmark, A., Lantorp, K., and Sterner, G., EBV antibodies in family contacts of patients with infectious mononucleosis, Proc. Soc. Exp. Biol. Med. 133:934–939 (1970).
Walters, M. K., and Pope, J. H., Studies of the EB virus-related antigens of human leucocyte cell lines, Int. J. Cancer 8:32–40 (1971).
Wechsler, H. F., Rosenblum, A. H., and Sills, C. T., Infectious mononucleosis: Report of an epidemic in an army post, Ann. Intern. Med. 25:113–133, 236–265 (1946).
Werner, J., Haff, R. F., Henle, G., Henle, W., and Pinto, C. A., Responses of gibbons to inoculation of Epstein-Barr virus, J. Infect. Dis. 126:678–681 (1972).
Yefenof, E., Bakacs, T., Einhorn, L., Ernberg, I., and Kelin, G., Epstein-Barr virus (EBV) receptors, complement receptors and EBV infectibility of different lymphocyte fractions of human peripheral blood, Cell. Immunol. 35:34–42 (1978).
West, J. P., An epidemic of glandular fever, Arch. Pediatr. 13:889–900 (1896).
Wising, P. J., A study of infectious mononucleosis (Pfeiffer’s disease) from the etiological point of view, Acta Med. Scand. Suppl. 133:1–102 (1942).
Wöllner, D., Ueber die serologische Diagnose der infektiösen Mononukleose nach Paul-Bunnell mit nativen and fermentierten Hammel Erythrocytes 2, Immunitaets Forsch. 112:290–308 (1955).
Wroblewski, F., Increasing clinical significance of alterations in enzymes in body fluids, Ann. Intern. Med. 50:62–93 (1959).
Zajac, B. A., andKohn, G., Epstein-Barr virus antigens, marker chromosomes, and interferon production in clones derived from cultured Burkitt tumor cells, J. Natl. Cancer Inst. 45:399–406 (1970).
Zur Hausen, H. H., Clifford, P., Henle, G., Henle, W., Klein, G., Santesson, L., and Schulte-Hol-IHAUSEN, H., EB-virus DNA in biopsies of Burkitt tumors and anaplastic carcinomas of the nasopharynx, Nature (London) 228:1056–1057 (1970).
Zur Hausen, H., Dorrier, K., Egger, H., Schulte-Holthausen, H., and Wolf, H., Attempts to detect virus-specific DNA in human tumors. II. Nucleic acid hybridizations with complementary RNA of human herpes group viruses, Int. J. Cancer 13:657–664 (1974).
Suggested Reading
Carter, R. L., and Penman, H. G. (eds.), Infectious Mononucleosis, Blackwell, Oxford, 1969.
Chervenick, P. A., Infectious mononucleosis, Dis.-Mon. 1–56 (December 1974)
Evans, A. S., Infectious mononucleosis and related syndromes, Am. J. Med. Sci. 276:325–339 (1978).
Glade, P. R. (ed.), Infectious Mononucleosis, Lippincott, Philadelphia, 1973.
Henle, W., and Henle, G., Epstein-Barr virus, Sci. Am. 241:48–59 (1979).
Hoagland, R., Infectious Mononucleosis, Grune and Stratton, New York, 1967.
Klein, G., The Epstein-Barr Virus in Herpesviruses (A. S. Kaplan, ed.), Academic Press, New York, 1973.
Miller, G., Epstein-Barr virus and infectious mononucleosis, Prog. Med. Virol. 20:84–112 (1975)
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Evans, A.S., Niederman, J.C. (1982). Epstein-Barr Virus. In: Evans, A.S. (eds) Viral Infections of Humans. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3237-4_10
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