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Solvent Effects on Some Nucleophilic Substitutions

  • Michael H. Abraham

Abstract

The effects of hydroxylic solvents on △G values for the solvolysis of t-butyl chloride have been dissected into initial-state and transition-state contributions. The △G°t(Tr) values, after correction for the “size” or “cavity” effect, are well correlated with values for the Me4N+ C1 ion-pair and for α-aminoacids. Similar calculations have been carried out for other alkyl halides and for SN2 reaction of triethylamine with ethyl iodide. Dissections of △H and △S for these SN1 and SN2 reactions into initial-state effects are also reported.

Keywords

Transition State Solvent Effect Alkyl Halide Transition State Theory Ethyl Iodide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Michael H. Abraham
    • 1
  1. 1.Department of ChemistryUniversity of SurreyGuildfordUK

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