Skip to main content

Abstract

Trace elements often have a bimodal or even a trimodal effect. Severe deficiency of certain trace metals can result in death or severe crippling of an animal or in birth defects of the newborn. The next level of intake is the nutritional level where chronic deficiency over a lifetime may cause major diseases such as cancer and heart disease. The next level of intake is the toxic level which may result in severe crippling or death of the animal. The primary area of concern in this chapter will be the nutritional intake level and the deficiency level and their relationship to animal or human disease. The trace elements described in this chapter are: chromium; cobalt; copper; fluorine; iodine; iron; manganese; molybdenum; nickel; silicon; selenium; tin; vanadium; and zinc.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Bibliography

  • Adler P., and Straub, J., 1953, Water-borne caries - protective agent other than fluorine, Acta Med. Acad. Sci. Hung. 4:221.

    Google Scholar 

  • Aeschlimann, M.I., Grant, J.A., and Grigler, Jr., J.F., 1966, Effects of sodium fluoride on the clinical course and metabolic balance of an infant with osteogenesis imperfecta congenita, Metab. Clin. Exp. 15:905.

    Article  Google Scholar 

  • Addink, N.W.H., and Frank, L.J.P., 1959, Remarks apropos of analysis of trace elements in human tissues, Cancer 12:544.

    Article  Google Scholar 

  • Addink, N.W.H., 1960, Subnormal levels of carbonic anhydrase in blood of carcinoma patients, Nature 186:253.

    Article  Google Scholar 

  • Allaire, B.I., and Campagna, A., 1961, Iron-deficiency anemia in pregnancy. Evaluation of diagnosis and therapy by bone marrow hemosiderin, Obstet Gynecol. 17:605.

    Google Scholar 

  • Allen, K.E.D., and Klevay, L.M., 1978, Copper deficiency and cholesterol metabolism in the rat, Atherosclerosis 31:259.

    Article  Google Scholar 

  • Allison, Jr., F., and Lancaster, M.G., 1964, Studies on factors which influence the adhesiveness of leukocytes “in vitro”, Ann. N.Y. Acad. Sci. 116:936.

    Article  Google Scholar 

  • Al-Rashid, R.A., and Spangler, J., 1971, Neonatal copper deficiency N. Eng. J. Med. 285:841.

    Article  Google Scholar 

  • Amdur, B.H., Billing, H., and Bloch, K., 1957, Enzymatic conversion of mevalonic acid to squalene, J. Amer. Chem. Soc. 79:2646.

    Article  Google Scholar 

  • Apgar, J., 1968a, Effect of zinc deficiency on parturition in the rat, Amer. J. Physiol. 215:160.

    Google Scholar 

  • Apgar, J., 1968b, Comparison of the effect of copper, manganese, and zinc deficiencies on parturition in the rat, Amer. J. Physiol. 215:1478.

    Google Scholar 

  • Arnold, Jr., F.A., 1957, Grand Rapids Fluoridation study; results pertaining to the eleventh year of fluoridation, Amer. J. Pub. Health 47:539.

    Article  Google Scholar 

  • Azaroff, D.L., Brick, F.E., and Curren, G.L., 1961, A specific site of vanadium inhibition of cholesterol biosynthesis, Biochem. Biophys. Acta 51:397.

    Article  Google Scholar 

  • Azaroff, D.L., and Curran, G.L., 1967, Site of vanadium inhibition of cholesterol biosynthesis, J. Amer. Chem. Soc. 79:2968.

    Article  Google Scholar 

  • Babenko, G.O., and Karplyuk, Z.V., 1963, Vplyv vydalennia pidshlunkovoi zalozyna vmist marhantsiu v tkanynakh ta orhanakh sobak, Ukr. Biokhim. Zh. 35:732.

    Google Scholar 

  • Barr, D.H., and Harris, J.W., 1973, Growth of the P388 leukemia as an ascites tumor in zinc-deficient mice, Proc. Soc. Exp. Biol. Med. 144:284.

    Google Scholar 

  • Beal, V.A., Myers, A.J., and McCammon, R.W., 1962, Iron intake, hemoglobin, and physical growth during the first two years of life, Pediatrics 30:518.

    Google Scholar 

  • Bearn, A.G., 1953, Genetic and biochemical aspects of Wilson’s disease, Amer. J. Med. 15:442.

    Article  Google Scholar 

  • Belyaev, P.M., 1938, Trace elements in the human organism. V. Influence of Mn ions on blood-sugar content, J. Physiol. (U.S.S.R.) 25:741.

    Google Scholar 

  • Benjanuvatra, N.K., and Bennien, M., 1975, Hair chromium concentration of Thai subjects with and without diabetes mellitus, Nutr. Rep. Int. 12:325.

    Google Scholar 

  • Bennetts, H.W., Beck, A.B., and Harley, R., 1939, Falling disease of cattle, Aust. Vet. J. 15:52.

    Article  Google Scholar 

  • Bennetts, H.W., Beck, A.B., and Harley, R., 1941, Falling disease of cattle, II. Copper deficiency, Aust. Vet. J. 24:237.

    Article  Google Scholar 

  • Bennetts, H.W., Harley, R., and Evans, S.T., 1942, Copper deficiency of cattle-fatal termination, Aust. Vet. J. 18:50.

    Article  Google Scholar 

  • Bernstein, D.S., Sadowsky, N., Hegsted, D.M., Guri, C.D., and Stare, F.J., 1966, Prevalence of osteoporosis in high and low-fluoride areas in North Dakota, J. Amer. Med. Assoc. 198:499.

    Article  Google Scholar 

  • Bertrand, G., and Macheboeuf, M., 1926, Influence du nickel et du cobalt sur l’action excercee par l’insulin chez le lapin, CR. Acad. Sci. 182:1504.

    Google Scholar 

  • Bjorksten, J.A., 1979, The primary cause of the high myocardic death rate in Eastern Finland defined as selenium deficiency, Rejuvenation 7:61.

    Google Scholar 

  • Blackmon, D.M., Miller, W.J., and Morton, J.D., 1967, Zinc deficiency in ruminents Occurrence, effects, diagnosis, and treatments. Vet. Med. 62:265.

    Google Scholar 

  • Bothwell, T.H., and Finch, C.A., 1962, “Iron Metabolism,” Boston, Little, Brown.

    Google Scholar 

  • Brown, H., 1927, The mineral content of human skin, J. Biol. Chem. 75:789.

    Google Scholar 

  • von Bunge, G., 1889, Uber die anufnahme des eisens in den organismus des sauglings, Hoppe-Seylers Z. Physiol. Chem. 13:399.

    Google Scholar 

  • Burk, D., and Yiamouyiannis, J., 1975, Fluoridation and cancer, 94th Congress, First Session, Congressional Record 121:7172.

    Google Scholar 

  • Buttner, W., 1961, Effects of some trace elements on fluoride retension and dental caries, Arch. Oral Biol. Suppl. 6:40.

    Article  Google Scholar 

  • Buttner, W., 1963, Action of trace elements on the metabolism of fluoride, J. Dent. Res. 42:453.

    Article  Google Scholar 

  • Calhoun, N.R., and Smith, J.C., 1968, Uptake of 65Zn in fractured bones, Lancet 2:682.

    Article  Google Scholar 

  • Carlton, W.W., and Henderson, W., 1963, Cardiovascular lesions in experimental copper deficiency, J. Nutr. 81:200.

    Google Scholar 

  • Carnes, W.H., Shields, G.S., Cartwright, G.E., and Wintrobe, M.M., 1961, Vascular lesions in copper deficient swine, Fed. Proc. 20:118.

    Google Scholar 

  • Cartwright, G.E., Hodges, R.D., Gubler, C.J., Mahoney, J.P., Daum, K., Wintrobe, M.M., and Bean, W.B., 1954, Studies on copper metabolism, XIII. Hepatolenticular degeneration, J. Clin. Invest. 33:1487.

    Article  Google Scholar 

  • Cass, R.M., Croft, J.D., Perkins, P., Nye, W., Waterhouse, C., and Terry, R., 1966, New bone formation in osteoporosis following treatment with sodium fluoride, Arch. intern. Med. 118:111.

    Article  Google Scholar 

  • Chugh, T.D., Dhingra, R.K., Gulati, R.C., and Bathla, J.C., 1973, Copper metabolism in schizophrenia, Indian J. Med. Res. 61:1147.

    Google Scholar 

  • Clayton, C.C., and Bauman, C.A., 1949, Diet and azo dye tumors; effect of diet during a period when the dye is not fed, Cancer Res. 9:575.

    Google Scholar 

  • Cohen, P., and Gardner, F.H., 1966, Induction of skeletal fluorosis in two common demineralizing disorders, J. Amer. Med. Assoc. 195:962.

    Article  Google Scholar 

  • Cohen, I.K., Schechter, P.J., and Henkin, R.I., 1973, Hypogeusia, anorexia, and altered zinc metabolism following thermal burn, J. Amer. Med. Assoc. 223:914.

    Article  Google Scholar 

  • Cordano, A., Baertl, J.M., and Graham, G.G., 1964, Copper deficiency in infancy, Pediatrics 34:324.

    Google Scholar 

  • Cordano, A., Placko, R.P., and Graham, G.G., 1966, Hypocupremia and neutropenia in copper deficiency, Blood 28:280.

    Google Scholar 

  • Coulson, W.F., and Carnes, W.H., 1963, Cardiovascular studies on copper-deficient swine, V. The histogenesis of the coronary artery lesions, Am. J. Pathol. 43:945.

    Google Scholar 

  • Curran, G.L., 1954, Effect of certain transition group elements on hepatic synthesis of cholesterol in the rat, J. Biol. Chem. 210:765.

    Google Scholar 

  • Curran, G.L., and Costello, R.L., 1956, Reduction of excess cholesterol in the rabbit aorta by inhibition by endogenous cholesterol synthesis, J. Exp. Med. 103:49.

    Article  Google Scholar 

  • Curran, G.L., Azaroff, D.L., and Bolinger, R.E., 1959, Effect of cholesterol synthesis inhibition in normocholesteremic young men, J. Clin. Invest. 38:1251.

    Article  Google Scholar 

  • Curran, G.L., and Burch, R.E., 1967, “Proc. First Ann. Conf. Trace Substances Environ. Health,” (D.D. Hemphill, ed), Univ. of Missouri.

    Google Scholar 

  • Danks, D.M., Stevens, B.J., Campbell, P.E., Gillespie, J.M., Walker-Smith, J., Bloomfield, J., and Turner, B., 1972a, Menkes kinky hair syndrome. Lancet 1:1100.

    Article  Google Scholar 

  • Danks, D.M., Campbell, P.E., Stevens, B.J., Mayne, V., and Cartwright, E., 1972b, Menkes kinky hair syndrome: An inherited defect in copper absorption with widespread effects, Pediatrics 50:188.

    Google Scholar 

  • Danks, D.M., Cartwright, E., Stevens, B.J., and Townley, R.R.W., 1973, Menkes kinky hair disease: Further definition of the defect in copper transport, Science 179:1140.

    Article  Google Scholar 

  • Darby, W.J., 1951, “Handbook of Nutrition,” 2nd Ed., McGraw-Hill (Blakiston), New York.

    Google Scholar 

  • Davidson, I.W.F., and Blackwell, W.L., 1968, Changes in carbohydrate metabolism of squirrel monkeys with chromium dietary supplementation, Proc. Soc. Exper. Biol. Med. 127:66.

    Google Scholar 

  • Davidson, I.W.F., and Burt, R.L., 1973, Physiologic changes in plasma chromium of normal and pregnant women, Am. J. Obstet. Gynaecol. 116:601.

    Google Scholar 

  • Dean, H.T., 1942, “Fluorine and dental health,” American Assoc. Advan. Sci., Washington, D.C.

    Google Scholar 

  • DeWys, W., Pories, W.J., Richter, M.C., and Strain, W.H., 1970 Inhibition of Walker 256 carcinosarcoma growth by dietary zinc deficiency, Proc. Soc. Exp. Biol. and Med. 135:17.

    Google Scholar 

  • Dimond, E.G., Caravaca, J., and Benchimol, A., 1963, Vanadium. Excretion, tocicity, lipid effect in man, Amer. J. Clin. Nutr. 12:49.

    Google Scholar 

  • Doisy, E.A., 1973, “Proceeding of the 6th Annual Conference on Trace Substances in Environmental Health,” (Hemphill, D.D., ed.) University of Missouri, Columbia, Mo.

    Google Scholar 

  • Doll, R., and Kinlen, L., 1977, Fluoridation of water and cancer mortality in the U.S.A., Lancet 1:1300.

    Article  Google Scholar 

  • Duncan, J.R., Dreosti, I.E., and Albrecht, C.F., 1974, Zinc intake and growth of a transplanted hepatoma induced by 3-methyl-4-dimethyl-aminoazobenzene in rats, J. Nat. Cancer Inst. 53:277.

    Google Scholar 

  • Dunlap, W.M., James, G.W., and Hume, D.M., 1974, Anemia and neutropenia caused by copper deficiency, Ann. Intern. Med. 80:470.

    Google Scholar 

  • Earl, C.J., Mouton, M.J., and Selverstone, V., 1954, Metabolism of copper in Wilson’s disease and in normal subjects: Studies with Cu64, Am. J. Med. 17:205.

    Article  Google Scholar 

  • Eichhorn, G.L., 1962, Metal ions as stabilizers or destabilizers of the deoxyribonucleic acid structure, Nature (London) 194:474.

    Article  Google Scholar 

  • Ellis, W.C., Pfander, W.H., Muhner, M.E., and Pickett, E.E., 1958, Molybdenum as a dietary essential for lambs, J. Anim. Sci. 17:180.

    Google Scholar 

  • Everson, G.J., Tsai, M.C., and Wang, T., 1967, Copper deficiency in the guinea pig, J. Nutr. 93:533.

    Google Scholar 

  • Everson, G.J., and Shrader, R.D., 1968, Abnormal glucose tolerance in manganese-deficient guinea pigs, J. Nutr. 94:89.

    Google Scholar 

  • Ezekiel, E., 1967, Intestinal iron absorption by neonates and some factors affecting it, J. Lab. Clin. Med. 70:138.

    Google Scholar 

  • Farquhar, J.D., 1963, Iron supplementation during first year of life, Amer. J. Dis. Child. 106:201.

    Google Scholar 

  • Fisher, G.L., Byers, V.S., Shifrine, M., and Levin, A.S., 1976, Copper and zinc levels in serum from human patients with sarcomas, Cancer 37;356.

    Article  Google Scholar 

  • Follis, Jr., R.H., Day, H.G., and McCollum, E.V., 1941, Histological studies of the tissue of rats fed a diet extremely low in zinc, J. Nutr. 22:223.

    Google Scholar 

  • Forrest, J.R., Parfitt, G.J., and Bransby, E.R., 1951, Incidence of dental caries among adults and young children in 3 high-and 3 low-fluorine areas in England, Mon. Bull. Min. Health Pub. Health Serv. 10:104.

    Google Scholar 

  • Geyer, C.F., 1953, Vanadium, caries-inhibiting trace element in Syrian hamster, J. Dent. Res. 32:590.

    Article  Google Scholar 

  • Gibson, J.G., Vallee, B.L., Fluharty, R.G., and Nelson, J.E., 1950, Studies of the zinc content of the leukocytes in myelogenous leukemia, Acta Unio Intern. Contra Cancrum. 6:1102.

    Google Scholar 

  • Glinsmann, W.H., and Mertz., W., 1966, Effects of trivalent chromium on glucose tolerance, Metabolism 15:510.

    Article  Google Scholar 

  • Godwin, K.O., 1965, Abnormal electrocardiograms in rats fed a low-selenium diet, Quart. J. Exp. Phys. 50:282.

    Google Scholar 

  • Godwin, K.O., and Fraser, F.J., 1966 Abnormal electrocardiograms blood pressure changes and some aspects of the histopathology of selenium deficiency in lambs, Quart. J. Exp. Phys. 51:94.

    Google Scholar 

  • Goldenberg, S. Blumenthal, H.T., 1964, “Diabetes Mellitus, Diagnosis and Treatment, Amer. Diabetes Assoc., New York.

    Google Scholar 

  • Graham, G.G., and Cordano, A., 1969, Copper depletion and deficiency in malnourished infants, The Johns Hopkins Med. J. 124:139.

    Google Scholar 

  • Griffin, A.C., and Jacobs, M.M., 1977, Effects of selenium on azo dye hepatocarcinogenesis, Cancer Lett. 3:177.

    Article  Google Scholar 

  • Grossmann, A., and Grossmann, G.F., 1955, Protein-bound iodine by alkaline incineration and a method for producing a stable cerate color, J. Clin. Endocrinol. Metab. 15:354.

    Article  Google Scholar 

  • Hallman, B.L., Bondy, P.K., and Hagewood, M.A., 1951, Determination of serum protein-bound iodine as a routine clinical procedure, Arch. Intern. Med. 87:817.

    Google Scholar 

  • Handjani, A.M., Smith, Jr., J.C., Herrmann, J.B., and Halsted, J.A., 1974, Serum zinc concentration in acute myocardial infarction, Chest 65:185.

    Article  Google Scholar 

  • Harr, J.R., Exon, J.H., Whanger, P.D., and Weswig, P.H., 1972, Effect of dietary selenium on N-2 fluorenyl-acetamide (FAA)-induced cancer in vitamin E supplemented, selenium depleted rats, Clin. Toxicol. 5:187.

    Article  Google Scholar 

  • Harris, R., 1959, Observations on the effect of topical sodium fluoride on caries incidnece in children, Aust Dent. J. 4:257.

    Article  Google Scholar 

  • Hawksley, J.C., Lightwood, R., and Bailey, U.M., 1934, Iron-deficiency anaemia in children: Its association with gastrointestinal disease, achlorhydria and hemorrhage, Arch. Dis. Child 9:359.

    Article  Google Scholar 

  • Healy, W.B., Ludwig, T.G., and Losee, F.L., 1961, Soils and dental caries in Hawke’s Bay, New Zealand, Soil Sci. 92:359.

    Article  Google Scholar 

  • Hein, J.W., and Wilsotzky, J., 1955, Effect of ten ppm vanadium drinking solution on dental caries in male and female Syrian hamsters, J. Dent. Res. 34:756.

    Google Scholar 

  • Henzel, J.H., Holtman, B., Keitzer, F.W., DeWeese, M.S., and Lichti, E., 1968, Trace elements in atherosclerosis, efficacy of zinc medication as a therapeutic modality, 2nd Annual Conf. on Trace Sub. in Environ. Health., (D.D. Hemphill, ed.), Univ. of Missouri.

    Google Scholar 

  • Herishanu, Y., and Loewinger, E., 1972, Torsion dystony and abnormal copper metabolism, Europ. Neurol. 8:251.

    Article  Google Scholar 

  • Higgins, E.S., Richert, D.A., Westerfield, W.W., 1956, Molybdenum deficiency and tungstate tungstate inhibition studies, J. Nutr. 59:53.

    Google Scholar 

  • Hoover, R.N., McKay, F.W., and Fraumen, Jr., J.F., 1976, Fluoridated drinking water and the occurrence of cancer, J. Natl. Cancer Inst. 57:757.

    Google Scholar 

  • Hopkins, L.L., Jr., and Price, M.G., 1968, Effect of chromium supplementation on middle-age diabetics, Proc. Western Hemisphere Nutr. Congr., Puerto Rico, Vol. 11:40.

    Google Scholar 

  • Hopkins, Jr., L.L., 1974, “Trace Element Metabolism in Animals,” Vol. 2., (W.G. Hoekstra, J.W. Suttie, H.E. Ganther, and W. Mertz, eds.), University Park Press, Baltimore.

    Google Scholar 

  • Hopkins, Jr., L.L., and Mohr, H.E., 1974, Vanadium as an essential nutrient, Fed. Proc. 33:1773.

    Google Scholar 

  • Hrgovcic, M., Tessmer, C.F., Minckler, T.M., Mosier, B., and Taylor, G.H., 1968, Serum copper levels in lymphoma and leukemia, Cancer 21:743.

    Article  Google Scholar 

  • Hunt, C.E., Landesman, J., and Newberne, P.M., 1970, Copper deficiency in chicks: effects of ascorbic acid on iron, copper, cytochrome oxidase activity, and aortic mucopolysaccharides, Brit. J. Nutr. 24:607.

    Article  Google Scholar 

  • Hurley, L.S., and Swenerton, H., 1966, Congenital malformation resulting from zinc deficiency in rats, Proc. Soc. Exper. Biol. Med. 123:692.

    Google Scholar 

  • Hussain, R., Walker, R.B., Layrisse, M., Clark, P., and Finch, C.A., 1965, Nutritive value of food iron, Amer. J. Clin. Nutr. 16:464.

    Google Scholar 

  • Iber, F.L., Chalmers, T.C., and Uzman, L.L., 1957, Studies of protein metabolism in hepatolenticular degeneration, Metabolism 6:388.

    Google Scholar 

  • Jeejeebhey, K.N., Chu, R.C., Marliss, E.B., Greenberg, G.R., and Brue-Robertson, A., 1977, Chromium deficiency, glucose intolerance, and neuropathy reversed by chromium supplementation, in a patient receiving long-term total parenteral nutrition, Amer. J. Clin. Nutr. 30:531.

    Google Scholar 

  • Jacobs, M.M., Jansson, B., and Griffin, A.C., 1977, Inhibitory effects of selenium on 1,2-dimethylhydrazine and methylazoxymethanol acetate induction of colon tumors, Cancer Lett. 2:133.

    Article  Google Scholar 

  • Jones, L.P.H., and Handreck, K.A., 1967, Silica in soils, plants and animals, Advan. Agron. 19:107.

    Article  Google Scholar 

  • Jordan, W.A., Snyder, J.R., and Wilson, V., 1958, Stannous fluoride clinical study in Olmsted County, Minnesota, Pub. Health Rep. 73:1010.

    Google Scholar 

  • Karpel, J.T., and Peden, V.H., 1972, Copper deficiency in long-term parenteral nutrition, J. Pediatr. 80:32.

    Article  Google Scholar 

  • Kelly, F.C., and Snedden, W.W., 1960, Prevalence and geographical distribution of endemic goiter, World Health Organ., Mon. Ser. 44:27.

    Google Scholar 

  • Kelly, W.A., Kesterson, J.W., and Carlton, W.W., 1974, Myocardial lesions in the offspring of female rats fed a copper deficient diet, Exper. Molec. Path. 20:40.

    Article  Google Scholar 

  • Kekki, M., Koskelo, P., and Lassus, A., 1966, Serum ceruloplasmin-bound, copper-bound copper and non-ceruloplasmin copper in uncomplicated psoriasis, J. Invest. Derm. 47:159.

    Google Scholar 

  • Keshan Disease Research Group of the Chinese Academy of Science, 1979, Chinese Medical J. In press.

    Google Scholar 

  • Knutson, J.W., and Armstrong, D.W., 1943, Effect of topically applied sodium fluoride on dental caries experience, Pub. Health Resp. 58:1701.

    Google Scholar 

  • Knutson, J.W., and Armstrong, D.W., 1945, Effect of topically applied sodium fluoride on dental caries experience; report of findings for second study year, Pub. Health Rep. 60:1085.

    Google Scholar 

  • Knutson, J.W., and Armstrong, D.W., 1946, Effect of topically applied sodium fluoride on dental caries experience; report of findings for third study year, Pub. Health Rep. 61:1683.

    Google Scholar 

  • Knutson, J.W., Armstrong, D.W., and Feldman, F.M., 1947, Effect of topically applied sodium fluoride on dental caries experience; report of findings with 2, 4 and 6 applications, Pub. Health Rep. 62:425.

    Google Scholar 

  • Korkov, V.V., 1965, Vanadiia Vfrofilaktike i lechenii eksperimental’ nogo ateroskleroza, Farmakol Toksikol 28:83.

    Google Scholar 

  • Klevay, L.M., and Forebush, J., 1976, Copper metabolism and the epidemiology of coronary heart disease, Nutr. Rep. Int. 14:221.

    Google Scholar 

  • Kosenko, L.G., 1964, Soderzhanie nekotorykh microelementol v krevi bol’nykh sakharnym diabetom, Klin. Med. (Moscow) 42:113.

    Google Scholar 

  • Kratzer, F.H., Vohra, P., Albred, J.B., and Davies, P.N., 1958, Effect of zinc upon growth and incidence of perosis in turkey poults, Proc. Soc. Exp. Biol. Med. 98:205.

    Google Scholar 

  • Kruger, B.J., 1958, Effect of trace elements on experimental dental caries, II. Al, B, Fl, I, V, J. Aust. Dent. Assoc. 3:236.

    Article  Google Scholar 

  • Kubota, J., Allaway, W.H., Carter, D.L., Cary, E.E., and Lazar, V.A., 1967, Selenium in crops in the United States in relation to selenium responsive diseases of animals, J. Agric. Food Chem. 15:448.

    Article  Google Scholar 

  • Laufberger, V., 1937, Sur la cristallisation de la ferritine, Bull. Soc. Chim. Biol. 19;1575.

    Google Scholar 

  • Lees, F., and Rosenthal, F.D., 1958, Gastric mucosal lesions before and after treatment in iron deficiency anaemia, Quart. J. Med. 27:19.

    Google Scholar 

  • Leone, N.C., Stevenson, C.A., Beese, B., Hawes, L.E., and Dawber, T.A., 1960, The effects of the absorption of fluoride, II. A radiological investigation of five hundred and forth-six human residents of an area in which the drinking water contained only a minute trace of fluoride, Amer. Med. Assoc. Arch. Ind. Health 21:326.

    Google Scholar 

  • Leone, N.C., Shimkin, M.B., Arnold, E.A., Stevenson, C.A., Zimmerman, E.R., Geiser, B.G., and Lieberman, J.J., 1964, In fluoridation as a Public Health Measure, Amer. Assoc. Advan. Sci., Washington, D.C.

    Google Scholar 

  • Leslie, J.G., Kung-Ying, K., and McGavack, T.H., 1962, Silicon in biological material, II. Variations in silicon contents in tissues of rat at different ages, Proc. Soc. Exp. Biol. Med. 110:218.

    Google Scholar 

  • Levine, R.A., Streeten, D.H.P., and Doisy, R.J., 1968, Effects of oral chromium supplementation on the glucose tolerance of elderly human subjects, Metabolism 17:114.

    Article  Google Scholar 

  • Lewis, C.E., 1959, The biological effects of vanadium, II. The signs and symptoms of occupational vanadium exposure, Amer. Med. Assoc. Arch. Int. Health 19:419.

    Google Scholar 

  • Lipkin, G., Herrmann, F., and Mandol, L., 1962, Studies on serum copper, I. The copper content of blood serum in patients in psoriasis, J. Invest. Derm. 39:593.

    Google Scholar 

  • Loeper, J., Loeper, J., and Lemaire, A., 1966, Etude du silicum en biologie animals et au cours de l’atherome, Presse Med. 74:865.

    Google Scholar 

  • Ludwig, T.L., Healy, W.B., and Losee, F.L., 1960, An association between dental caries and certain soil conditions in New Zealand, Nature (London) 186:695.

    Article  Google Scholar 

  • MacCardle, R.C., Engman, Jr., M.F., and Engman, Sr., M.F., 1943, Mineral changes in neurodermatitis revealed by microincineration, Arch. Dermatol. Syphilol. 47:335.

    Google Scholar 

  • Malamos, B., Koutras, D.A., Kostamis, P., Kralios, A.C., Rigopoulos, G., and Zerefos, N., 1966, Endemic goiter in Greece: Epidemiologic and genetic studies, J. Clin. Endocrinol. Metab. 26:688.

    Article  Google Scholar 

  • Malthus, R.S., Ludwig, T.G., and Healy, W.B., 1964, Effects of trace elements on dental caries in rats, N.Z. Dent. J. 60:291.

    Google Scholar 

  • Marshall, M.V., Jacobs, M.M. and Griffin, A.C., 1978, Reduction in acetylaminoflurene (AAF) hepatocarcinogenesis by selenium Proc. Amer. Cancer Res. 19:75.

    Google Scholar 

  • McConnell, K.P, Broghamer, Jr., W.L., Blotcky, A.J., and Hurt, O.J., 1975, Selenium levels in human blood and tissues in health and in disease, J. Nutr. 105:1026.

    Google Scholar 

  • McKay, F.S., 1948, Mass control of dental caries through use of domestic water supplies containing fluorine, Amer. J. Pub. Health 38:328.

    Article  Google Scholar 

  • McNeely, M.D., Sunderman, Jr., F.W., Nechay, M.W., and Levine, H., 1971, Abnormal concentrations of nickel in serum in cases of myocardial infarction, stroke, burns, hepatic cirrhosis and uremia, Clin. Chem. 17:1123.

    Google Scholar 

  • McQuilty, Jr., J.T., DeWys, W.D., Monaco, L., Strain, W.H., Rob, C.G., Apgar, J., and Pories, W.J., 1970, Inhibition of tumor growth by dietary zinc deficiency, Cancer Res. 30:1387.

    Google Scholar 

  • Meeks, M.J., Lundelt, R.R., Kessler, W.V., and Born, G.S., 1971, Effect of vanadium on metabolism of glucose in the rat, J. Pharm. Sci. 60:482.

    Article  Google Scholar 

  • Menkes, J.H., 1972, Kinky hair disease, Pediatrics 50:181.

    Google Scholar 

  • Mertz, W., Roginski, E.E., and Schwarz, K., 1961, Effect of trivalent chromium complexes on glucose uptake by epididymal fat tissue of rats, J. Biol. Chem. 236:318.

    Google Scholar 

  • Mertz, W., Roginski, E.E., and Reba, R., 1965, Biological activity and fate of trace quantities of intravenous chromium (III) in the rat, Am. J. Physiol. 209:489.

    Google Scholar 

  • Michaelsson, G., 1974, Zinc therapy in acrodermatitis enteropathica, Acta Derm. Venerol. (Stockh) 54:377.

    Google Scholar 

  • Michaelsson, G., Juhlin, L., Vahlquist, A., 1977, Effects of oral zinc and vitamin A in acne, Arch, of Dermatology 113:31.

    Article  Google Scholar 

  • Millar, M.J., Fi scher, M.I., Elcoate, P.V., and Mawson, C.A., 1958, The effects of dietary zinc deficiency on the reproductive system of male rats, Canad. J. Biochem. Physiol. 36:557.

    Article  Google Scholar 

  • Millar, M.J., Fischer, M.I., Elcoate, P.V., and Mawson, C.A., 1960, Effect of testosterone and gonadotropin injections on the sex organ development of zinc-deficient male rats, Can. J. Biochem. Physiol. 38:1457.

    Article  Google Scholar 

  • Miller, W.J., Pitts, W.J., Clifton, C.M., and Schmittle, S.C., 1964, Zinc deficiency in the goat, J. Dairy Sci. 47:556.

    Article  Google Scholar 

  • Miller, W.J., Morton, J.D., Pitts, W.J., and Clifton, C.M., 1965, Effect of zinc deficiency and restricted feeding on wound healing in the bovine, Proc. Soc. Exp. Biol. Med. 118:427.

    Google Scholar 

  • Miller, W.J., Blackmon, D.M., Gentry, R.P., Powell, G.W., and Perkins H.E., 1966, Influence of zinc deficiency on zinc and dry malter content of ruminant tissues and on excretion of zinc, J. Dairy Sci. 49:1446.

    Article  Google Scholar 

  • Mills, C.F., Dalgarno, A.C., Williams, R.B., and Quarterman, J., 1967, Zinc deficiency and the zinc requirement of calves and lambs. Brit. J. Nutr. 21:751.

    Article  Google Scholar 

  • Molokhia, M.M., and Portnoy, B., 1970, Neutron activation analysis of trace elements in skin, V. Copper and zinc in psoriasis, Brit. J. Derm. 83:376.

    Article  Google Scholar 

  • Morgan, J.M., 1972, Hepatic chromium content in diabetic subjects, Metabolism 21:313.

    Article  Google Scholar 

  • Mountain, J.T., Stockwell, F.R., and Stokinger, H.E., 1956, Effect of ingested vanadium on cholesterol and phospholipid metabolism in the rabbit, Proc. Soc. Exp. Biol. 92:582.

    Google Scholar 

  • Moynahan, E.J., 1974, Acrodermatitis enteropathica: a lethal inherited human zinc deficiency disorder, Lancet 2:399.

    Article  Google Scholar 

  • Muhlemann, H.R., and Konig, K.G., 1964, Die fressgewohneiten der ratten im Zusammenhang mit der kariesforschung, Int. Z. Vitamin Forsch 34:426.

    Google Scholar 

  • Muhler, J.C., 1957, The effect of vanadium pentoxide, fluorides, and tin compounds on the dental caries experience in rats, J. Dent. Res. 36:787.

    Article  Google Scholar 

  • Mukai, F.H., and Goldstein, B.D., 1976, Mutagenicity of malonaldehyde, a decomposition product of peroxidized polyunsaturated fatty acids, Science 191:868.

    Article  Google Scholar 

  • Mukherjee, C., and Mukherjee, S.K., 1953, Studies in iron metabolism in anaemias in pregnancy; serum iron, J. Indian Med. Assoc. 22:345.

    Google Scholar 

  • Murray, J., and Rosenthal, S., 1968, The effects of locally applied zinc and aluminum on healing incised wounds, Surg. Gynecol. Obstet. 126:1298.

    Google Scholar 

  • Naylor, M.N., 1969, Recent advances in the prevention of caries, Ann. Roy. Coll. Surg. Eng 45:305.

    Google Scholar 

  • Newman, Howard, A.I., Leighton, R.F., Lanese, R.R., and Freedland, N.A., 1978, Serum chromium and angiographically determined coronary artery disease, Clin. Chem. 24:541.

    Google Scholar 

  • Niell, H.B., Leach, B.E., and Kraus, A.P., 1979, Zinc metabolism in sickle cell anemia, J. Amer. Med. Assoc. 242:2686.

    Article  Google Scholar 

  • O’Dell, B.L., and Savage, J.E., 1957, Symptoms of zinc deficiency in the chick, Fed. Proc. 16:394.

    Google Scholar 

  • O’Dell, B.L., Newberne, P.M., and Savage, J.E., 1958, Significance of dietary zinc for the growing chicken, J. Nutr. 65:503.

    Google Scholar 

  • O’Dell, B.L., Hardwick, B.C., Reynolds, G., and Savage, J.E., 1961, Connective tissue defect in the chick resulting from copper deficiency, Proc. Soc. Exp. Biol. Med. 108:402.

    Google Scholar 

  • Orten, J.M., 1966, “Zinc Metabolism,” (Prasad, A.S., ed.), Thomas, Springfield, Illinois.

    Google Scholar 

  • Perry, J. Jr., H.H., 1973, Minerals in cardiovascular disease, J. Am. Diet. Assoc. 62:631.

    Google Scholar 

  • Perry, Jr., H.M., Perry, E.F., and Erlanger, M.W., 1974, Reversal of cadmium induced hypertension by selenium or hard water, in “Proc. Eighth Conf. Trace Sub. Environ. Health,” (D.D. Hemphill, ed.), University of Missouri.

    Google Scholar 

  • Pitts, W.J., Miller, W.J., Fosgate, O.T., Morton, J.D., and Clifton C.M., 1966, Effect of zinc deficiency and restricted feeding from two to five months of age on reproduction in Holstein bulls, J. Dairy Sci. 49:995.

    Article  Google Scholar 

  • Plumlee, M.P., Thrasher, D.M., Beeson, W.N., Andrews, F.N., and Parker, H.E., 1954, Effects of manganese deficiency on growth development and reproduction of swine, J. Anim. Sci. 13:996.

    Google Scholar 

  • Plumlee, M.P., Thrasher, D.M., Beeson, W.N., Andrews, F.N., and Parker, H.E., 1956, The effects of a manganese deficiency upon the growth, development and reproduction of swine, J. Anim. Sci. 15:352.

    Google Scholar 

  • Pories, W.J., and Strain, W.H., 1966, “Zinc Metabolism,” (A.S. Prasad, ed.), Thomas, Springfield, Illinois.

    Google Scholar 

  • Pories, W.J., Henzel, J.H., Rob, C.G., and Strain, W.H., 1967, Acceleration of healing with zinc sulfate, Ann. Surg. 165:432.

    Article  Google Scholar 

  • Pories, W.J., Henzel, J.H., and Hennessen, J.A., 1968, In Proc. First Ann. Conf. Trace Substances in Environ. Health, (D.D. Hemphill, ed.), University of Missouri.

    Google Scholar 

  • Poswillo, D.E., and Cohen, B., 1971, Inhibition of carcinogenesis by dietary zinc, Nature 231:447.

    Article  Google Scholar 

  • Prasad, A.S., Halsted, J.A., and Nadimi, M., 1961, Syndrome of iron deficiency anemia, hepatosplenomegaly, hypogonadism, dwarfism, and geophagia, Am. J. Med. 31:532.

    Article  Google Scholar 

  • Prasad, A.S., Miale, A., Farid, Z., Sandstead, H.H., Schulert, A. and Darby, W.J., 1963, Biochemical studies on dwarfism, hypogonadism, and anemia, Arch. Intern. Med. 111:407.

    Google Scholar 

  • Pritchard, J.A., and Hunt, C.E., 1958, A comparison of the hematologic responses following the routine prenatal administration of intramuscular and oral iron, Surg. Gynecol. Obstet. 106:516.

    Google Scholar 

  • Purves, M.J., 1962, Some effects of administering sodium fluoride to patients with Paget’s disease, Lancet 2:1188.

    Article  Google Scholar 

  • Quarantillo, Jr., E.P., 1971, Effect of supplemental zinc on wound healing in rats, Amer. J. Surg. 121:661.

    Article  Google Scholar 

  • Rahmet, A., Norman, J.N., and Smith, G., 1974, The effect of zinc deficiency on wound healing, Brit. J. Surg. 61:271.

    Article  Google Scholar 

  • Rapport, R.L., and Curtis, G.M., 1950, The clinical significance of the blood iodine, Endocrinol. 10:735.

    Google Scholar 

  • Reid, B.L., Kurnich, A.A., Svacha, R.L., and Crouch, J.R., 1956, The effect of molybdenum on chick and poult growth, Proc. Soc. Exp. Biol. Med. 93:245.

    Google Scholar 

  • deRenzo, E.C., Kaleita, E., Heytler, P., Oleson, J.J., Hutching, B.L., and Williams, J.H., 1953a, The nature of the zanthine oxidase factor, J. Amer. Chem. Soc 75:753.

    Article  Google Scholar 

  • deRenzo, E.C., Kaleita, E., Heytler, P., Oleson, J.J., Hutching, B.L., and Williams, J.H., 1953b, Indentification of xanthine oxidase factor as molybdenum, Arch. biochem. Biophys. 45:247.

    Article  Google Scholar 

  • Rich, C., Ensinck, J., and Ivanocitch, P., 1964, The effects of sodium fluoride on clacium metabolism of subject with metabolic bone disease, J. Clin. Invest. 43:545.

    Article  Google Scholar 

  • Richert, D.A., and Westerfield, W.W., 1953, The relationship of iron to xanthine oxidase, J. Biol. Chem. 203:915.

    Google Scholar 

  • Roginski, E.E., and Mertz, W., 1967a, An eye lesion in rats fed low-chromium diets, J. Nutr. 93:249.

    Google Scholar 

  • Roginski, E.E., and Mertz, W., 1967b, Dietary chromium and amino acid incorporation in rats on a low-protein ration, Fed. Proc. 26:255.

    Google Scholar 

  • Roginski, E.E., and Mertz, W., 1969, Effects of chromium (III) supplementation on glucose and amino acid metabolism in rats fed a low protein diet, J. Nutr. 97:525.

    Google Scholar 

  • Rubenstein, A.H., 1962, Hypoglycaemia induced by manganese, Nature 194:188.

    Article  Google Scholar 

  • Russell, A.L., and Elvore E., 1951, Domestic water and dental caries; study of fluoride-dental caries relationship in adult population, Pub. Health Rep. 66:1389.

    Google Scholar 

  • Rybo, G., 1966, Menstrual blood loss in relation to parity and menstrual pattern, Acta Obstet. Gynecol. Scand. 45 (suppl.), 7:25.

    Article  Google Scholar 

  • Rygh, O., 1949a, Recherches sur les oligo-elements; de l’importance du strontium, du baryum et du zinc, Bull, Soc. Chim. Biol. 31:1052.

    Google Scholar 

  • Rygh, O., 1949b, Recherches sur les oligo-elements; de l’importance CRL du thallium et du vanadium, du silicon et du fluor, Bull. Soc. Chim. Biol. 31:1403.

    Google Scholar 

  • Rygh, O., 1949c, Recherches sur les oligo-elements; sur l’importance du strontium, du vanadium, du baryum, du thallium et du zinc dans le scorbut, Bull. Soc. Chim. Biol. 31:1408.

    Google Scholar 

  • Rygh, O., 1951, Sur les reactions des acides amines soufres, specialement en correlation avec le scorbut,et l’influence des deux facteurs antiscorbutiques naturels, Bull. Soc. Chim. Biol. 33:133.

    Google Scholar 

  • Sandstead, H.H., and Shepard, G.H., 1968, The effect of zinc deficiency on the tensile strength of healing surgical incisions in the integument of the rat, Proc. Soc. Exper. Biol. Med. 128:687.

    Google Scholar 

  • Savlov, E.D., Strain, W.H., and Huegin, F., 1962, Radiozinc studies in experimental wound healing, Jour. Surg. Research 2:209.

    Article  Google Scholar 

  • Schechter, P.J., Friedewald, W.T., Bronzert, D.A., Raff, M.S., and Henkin, R.I., 1972, Ideopathic hypogeusia: A description of the syndrome and a single blind study with zinc sulfate, International Review of Neurobiology, Suppl. 1:125 (Ed. by Pfeiffer, C.C.) New York, Academic Press.

    Google Scholar 

  • Scheinberg, I.H., and Gittlin, D., 1952, Deficiency of ceruloplasmin in patients with hepatolenticular degeneration (Wilson’s disease), Science 116:484.

    Article  Google Scholar 

  • Shrader, K.E., and Everson, G.J., 1968, Pancreatic pathology in manganese-deficient guinea pigs, J. Nutr. 94:269.

    Google Scholar 

  • Schrauzer, G.N., and Ishmael, D., 1974, Effects of selenium ane arsenic on the genesis of spontaneous mammary tumors in in-bred C3H mice, Ann. Clin. Lab. Sci. 4:441.

    Google Scholar 

  • Schrauzer, G.N., White, D.A., and Schneider, C.J., 1977, Cancer mortality correlation studies - III, Statistical association wtih dietary selenium intakes, Bioinorganic Chem. 7:23.

    Article  Google Scholar 

  • Schroeder, H.A., Vinton, W.H., Jr., and Balassa, J.J., 1962, Abnormal trace metals in man, J. Chronic Dis. 15:941.

    Article  Google Scholar 

  • Schroeder, H.A., Balassa, J.J., and Tipton, I.H., 1963, Abnormal trace metals in man-vanadium, J. Chronic Dis. 16:407.

    Article  Google Scholar 

  • Schroeder, H.A., and Balassa, J.J., 1965, Influence of chromium cadmium, and lead on rat aortic lipids and circulating cholesterol, Am. J. Physiol. 209:433.

    Google Scholar 

  • Schroeder, H.A., 1968, The role of chromium in mammalian nutrition, Am. J. Clin. Nutr. 21:230.

    Google Scholar 

  • Schroeder, H., 1969, Serum cholesterol and glucose levels in rats fed refined and less refined sugars and chromium, J. Nutr. 97:237.

    Google Scholar 

  • Schwarz, K., and Mertz, W., 1961, A physiological role of chromium (III) in glucose utilization (glucose tolerance factor), Fedetation Proc. 20 (Suppl. 2):III.

    Google Scholar 

  • Schwarz, K., Milne, D.B., and Vineyard, E., 1970, Growth effects of tin compounds in rats maintained in a trace element controlled environment, Biochem. Biophys. Res. Commun. 40:22.

    Article  Google Scholar 

  • Schwarz, K., 1974, “Trace Element Metabolism in Animals,” Vol. 2., W.G. Hoekstra, J.W. Suttie, H.E. Ganther, and W. Mertz, eds.), University Park Press, Baltimore.

    Google Scholar 

  • Scott, M.L., Holm, E.R., and Reynolds, R.E., 1959, Studies on the niacin, riboflavine, choline, manganese and zinc requirements of young ringnecked pheasants for growth, feathering, and prevention of leg disorders, Poultry Sci. 38:1344.

    Google Scholar 

  • Scrimshaw, N.S., 1960, Endemic goiter in Latin American, Pub. Health Rep. 75:731.

    Google Scholar 

  • Shamberger, R.J., and Rudolph, G., 1966, Protection against cocarcinogenesis by sntioxidants, Experientia 22:116.

    Article  Google Scholar 

  • Shamberger, R.J., 1970, Relationship of selenium to cancer, I. Inhibitory effect of selenium on carcinogenesis, J. Nat. Cancer Inst. 44:931.

    Google Scholar 

  • Shamberger, R.J., and Willis, C.E., 1971, Selenium distribution and human cancer mortality, C.R.C. Crit. Rev. Clin. Lab. Sci. 2:211.

    Article  Google Scholar 

  • Shamberger, R.J., Baughman, F.F., Kalchert, S.L. Willis, C.E., and Hoffman, G.C., 1973a, Carcinogen-induced chromosomal breakage decreased by antioxidants, Proc. Nat. Acad. Sci. (U.S.A.) 70:1461.

    Article  Google Scholar 

  • Shamberger, R.J., Rukovena, E., Longfield, A.K., Tytko, S.A., Deodhar, S., and Willis, C.E., 1973b, Antioxidants and Cancer. I. Selenium in the blood of normals and cancer patients, J. Nat. Cancer Inst. 50:863.

    Google Scholar 

  • Shamberger, R.J., Tytko, S., and Willis, C.E., 1974a, Antioxidants and cancer, II. Selenium distribution and human cancer mortality in the United States, Canada and New Zealand, Proc. Seventh Ann. Conf. Trace Sub. in Environ. Health, (D.D. Hemphill, ed.), University of Missouri.

    Google Scholar 

  • Shamberger, R.J., Andreone, T.L., and Willis, C.E., 1974b, Antioxidants and cancer, IV. Initiating activity of malonaldehyde as a carcinogen, J. Nat. Cancer Inst. 53:1771.

    Google Scholar 

  • Shamberger, R.J., Tytko, S.A., and Willis, C.E., 1975, Selenium and heart disease, “The Proc. Ninth Trace Sub. in Environ. Health.,” (D.D. Hemphill, ed.), University of Missouri.

    Google Scholar 

  • Shamberger, R.J., Tytko, S.A., and Willis, C.E., 1976, Antioxidants and cancer, VI. Selenium and age-adjusted human cancer mortality, Arch. Environ. Health 31:235.

    Google Scholar 

  • Shamberger, R.J., Shamberger, B.A., and Willis, C.E., 1977a, Malonaldehyde content of food, J. Nutr. 107:1404.

    Google Scholar 

  • Shamberger, R.J., 1977b, Selenium and cadmium ratios of human kidneys, 3rd Int. Symp. of Trace Element metabolism in Man and Animals, (Kirchgessner, M., ed.), Freising-Weihenstephan, West Germany.

    Google Scholar 

  • Shamberger, R.J., Gunsch, M.S. Willis, C.E., and McCormack, L.J., 1978, Selenium and heart disease, II. In the Proc. 12th Trace Sub. in Environ. Health, (D.D. Hemphill, ed.), University of Missouri.

    Google Scholar 

  • Shamberger, R.J., Corlett, C.L., Beaman, K.D., and Kasten, B.L., 1979a, Antioxidants reduce the mutagenic effect of malonaldehyde and B-propiolactone, Mutation Res. 66:349.

    Article  Google Scholar 

  • Shamberger, R.J., Willis, C.E., and McCormack, L.J., 1979b, Selenium and heart disease, III. Blood selenium and heart mortality in 19 states, “Proc. 13th Conf. Trace Sub. in Environ. Health.,” (D.D. Hemphill, ed.), University of Missouri, In press.

    Google Scholar 

  • Sherman, L., Glennon, J.A. Brech, W.J., Klomberg, G.H., and Gordon E.S., 1968, Failure of trivalent chromium to improve hyperglycemia in diabetes mellitus, Metab. Clin. Exptl. 17:439.

    Article  Google Scholar 

  • Shields, G.S., Coulson, W.F., Kimball, D.A., Carnes, W.H., Cartwright, G.E., and Wintrobe, M.M., 1962, Studies on copper metabolism, 32, Cardiovascular lesions in copper-deficient swine, Amer. J. Path. 41:603.

    Google Scholar 

  • Shokeir, M.H.F., and Shreffler, D.C., 1969, Cytochrome oxidase deficiency in Wilson’s disease: a suggested ceruloplasmin function, Proc. Nat. Acad. Sci. (USA) 62:867.

    Article  Google Scholar 

  • Simpson, C.F., and Harms, R.H., 1964, Pathology of the aorta of chicks fed a copper-deficient diet, Exp. Mol. Pathol. 3:390.

    Article  Google Scholar 

  • Singh, S., and Bresnan, M.J. 1973, Menkes kinky-hair syndrome (trichopoliodystrophy), Low copper levels in the blood, hair and urine, Amer. J. Dis. Child 125:572.

    Google Scholar 

  • Smith, Jr., J.C., McDaniel, E.G., and Fan, F.F., 1973, A trace element essential in vitamin A metabolism, Science 181:954.

    Article  Google Scholar 

  • Somerville, T., and Davies, B., 1962, Effect of vanadium on serum cholesterol, Amer. Heart J. 64:54.

    Article  Google Scholar 

  • Soremark, R., and Ullberg, S., 1962, In Use of Radioisotopes in Animal Biology and the Medical Sciences, (Fried, N. ed.), Academic, New York.

    Google Scholar 

  • Staub, H.W., Reussner, G., and Thiessen, Jr., R., 1969, Serum cholesterol reduction by chromium in hypercholesterolemic rats, Science 166:746.

    Article  Google Scholar 

  • Sturgeon, P., 1956, Studies of iron requirements in infants and children, II. The influence on normal infants of oral iron in therapeutic doses, Pediatrics 17:341.

    Google Scholar 

  • Sunderman, Jr., F.W., Nomoto, S., Pradhan, A.M., Levine, H., Bernstein, S.H., and Hirsch, R., 1970, Increased concentrations of serum nickel after acute myocardial infarction, N. Eng. J. Med. 283–896.

    Google Scholar 

  • Sunderman, Jr., F.W., Decsy, M.I., and McNeely, M.D., 1972, Nickel metabilism in health and disease, Ann. N.Y. Acad. Sci. 199:300.

    Article  Google Scholar 

  • Sunderman, Jr., F.W., 1973, Atomic absorption spectrometry of trace metals in clinical pathology, Human Pathol. 4:549.

    Article  Google Scholar 

  • Szmigielski, S., and Litwin, J., 1964, The histochemical demonstration of zinc in blood granulocytes, The new test in diagnosis of neoplastic diseases, Cancer 17:1381.

    Article  Google Scholar 

  • Tank, G., and Storrick, C.A., 1960, Dental caries experiences of school children in Corvallis, Oregon, after 7 years of fluoridation, J. Pediat. 58:528.

    Article  Google Scholar 

  • Taves, D.R., 1977, Fluoridation and Cancer Mortality, Origins of Human Cancer (Cold Spring Harbor Conferences on Cell Proliferation, Vol. 4), (H.H. Hiatt, J.D. Watson, J.A. Winsten, eds.), New York, Cold Spring Harbor Laboratory.

    Google Scholar 

  • Thomassen, P.R., and Leicester, H.M., 1964, Uptake of radioactive beryllium, vanadium, selenium, cerium and yttrium in the tissues and teeth of rats, J. Dent. Res. 43:346.

    Article  Google Scholar 

  • Todd, W.R., Elvehjem, C.A., and Hart, E.B., 1934, Zinc in the nutrition of the rat, Amer. J. Physiol. 107:146.

    Google Scholar 

  • Underwood, E.J., and Somers, M., 1967, Studies of zinc nutrition in sheep, I. The relation of zinc to growth, testicular development and spermattogenesis in young rams, Aust. J. Agr. Res. 20:889.

    Article  Google Scholar 

  • Uzman, L.L., Iber, F.L., and Chalmers, T.C., and Knowlton, M., 1956, The mechanism of copper deposition in the liver hepatolenticular degeneration (Wilson’s disease), Am. J. Med. Sci. 231:511.

    Article  Google Scholar 

  • Vikbladh, I., 1950, Studies on zinc in blood, Scand. J. Clin. Invest. 2:143.

    Article  Google Scholar 

  • Villalon, J.A.M., 1974, M.D. Thesis, Universidad Michocana de San Nicolas de Hidalgo, Morelia, Mexico, 23 pp., Cited by Frost, D.V. and Lish, P.M., 1975, Selenium in biology, Ann. Rev. Pharm. 15:259.

    Google Scholar 

  • Volkov, N.F., 1963, Cobalt, manganese, and zinc content in the blood of atherosclerosis patient, Fed. Proc. (Trans Suppl.) 22:T897.

    Google Scholar 

  • Voors, A.W., Johnson, W.D., Shuman, M.S., Blotcky, A.J., 1978, Adjusted cadmium levels in the renal cortex and human heart at autopsy, in “Proc. 13th Conf. Trace Sub. Environ. Health,” (D.D. Hemphill, ed.), University of Missouri.

    Google Scholar 

  • Wacker, W.E., Ulmer, D.D., and Vallee, B.L., 1956, Metalloenzymes and metalloenzymes and myocardial infarction, II. Malic and lactic activities and zinc concentration in serum dehydrogenase, New Eng. J. Med. 255:449.

    Article  Google Scholar 

  • Wacker, W.E.C., and Vallee, B.L., 1959, Nucleic acids and metals I. Chromium, manganese, nickel iron, and toher metals in ribonucleic acid from diverse biological sources, J. Biol. Chem. 234:3257.

    Google Scholar 

  • Wacker, W.E.C., Gordon, M.P., and Huff, J.W., 1963, Metal content of tobacco mosaic virus and tobacco mosacic virus RNA, Biochemistry 2:716.

    Article  Google Scholar 

  • Warren, R.L., Jelliffe, A.M., Watson, J.V., and Hobbs, C.B., 1969, Prolonged observations on variations in the serum copper in Hodgkins disease, Clin. Radiol. 20:247.

    Article  Google Scholar 

  • Wayne, E.J., Koutras, D.A., and Alexander, W.D., 1964, “Clinical Aspects of Iodine Metabolism,” Blackwell, Oxford.

    Google Scholar 

  • Westerfield, W.W., and Richert, D.A., 1953, Distribution of the xanthine oxidase factor (molybdenum) in foods, J. Nutr. 51:85.

    Google Scholar 

  • Wetterdal, B., 1958, Experimental studies on radioactive zinc in the male reproductive organs of the rat, Acta Radiol., Suppl., 156:5.

    Google Scholar 

  • Willimas, J., Thompson, E., and Smith, K.L., 1978, Value of serum copper levels and erythrocyte sedimentation rates as indicators of disease activity in children with Hodgkins disease, Cancer 42:1929.

    Article  Google Scholar 

  • Wilson, S.A.K., 1912, Progressive lenticular degeneration: a familial nervous disease associated with cirrhosis of the liver Brain 34:295.

    Article  Google Scholar 

  • Wintrobe, M.M., Cartwright, G.E., and Gubler, C.J., 1953, Studies on the function and metabolism of copper, J. Nutr. 50:395.

    Google Scholar 

  • Yiamouyiannis, J., and Burk, D., 1975, Cancer from our drinking water?, 94th Congress, First session, Congressional Record 121:12731.

    Google Scholar 

  • Yiamouyiannis, J., and Burk, D., 1977, Flouridation and cancer: Age-dependence of cancer mortality related to artificial fluoridation, Fluoride 10:102.

    Google Scholar 

  • Zimmerman, A.W., Matthieu, J.M., Quarles, R.H., Brady, R.O., and Hsu, J.M., 1976, Hypomyelination in copper-deficient rats, Archives Neur. 33:111.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1980 Plenum Press, New York

About this chapter

Cite this chapter

Shamberger, R.J. (1980). Trace Metals in Health and Disease. In: Brewster, M.A., Naito, H.K. (eds) Nutritional Elements and Clinical Biochemistry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3168-1_8

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-3168-1_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3170-4

  • Online ISBN: 978-1-4613-3168-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics