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The Clinical Implications of Lipid Antioxidant Nutrition

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Nutritional Elements and Clinical Biochemistry

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Abstract

Few areas in human nutrition are so charged with claims and counterclaims as is that of the antioxidant nutrients, and vitamin E specifically. The very name of vitamin E, tocopherol, reflects the considerable controversy which surrounds it, in that it is derived from the Greek word meaning “bringing forth in childbirth.” The fertility effect, however, since its early demonstration in rats by Evans and Bishop (1923), has not been demonstrated in humans. Vitamin E was discovered when Evans and Bishop (1923) isolated from vegetable oils a substance that helped rats produce robust offspring. Unfortunately, this observation was picked up by many individuals and promoted in the lay literature as a human “sex” vitamin. This clouded the scene with regard to the biological importance of vitamin E and has led to much misunderstanding concerning both the prophylactic and potential therapeutic benefit of vitamin E and other members of the lipid antioxidant family for the human being. The controversy surrounding it is summed up in a statement made by Tappel (1973): “While few compelling uses have been found for vitamin E, the more research which is done on this substance, the more intriguing it appears. Thus, there is a nagging suspicion that there is a very important use for the vitamin and we are just not smart enough to see it.”

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Author information

Authors and Affiliations

  1. Dept. of Chemistry, University of Puget Sounds, Tacoma, Washington, 98416, USA

    Jeffrey Bland Ph.D. (Assoc. Prof., Dir.)

  2. Bellevue-Redmond Medical Labs., Tacoma, Washington, 98416, USA

    Jeffrey Bland Ph.D. (Assoc. Prof., Dir.)

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  1. Jeffrey Bland Ph.D.
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Editor information

Editors and Affiliations

  1. Departments of Pathology, Biochemistry, and Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

    Marge A. Brewster

  2. Metabolic Laboratory, Arkansas Children’s Hospital, Little Rock, Arkansas, USA

    Marge A. Brewster

  3. Department of Biochemistry, Division of Laboratory Medicine, Department of A therosclerosis and Thrombosis Research, Division of Research, Cleveland Clinic Foundation, Cleveland, Ohio, USA

    Herbert K. Naito

  4. Department of Chemistry, Cleveland State University, Cleveland, Ohio, USA

    Herbert K. Naito

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© 1980 Plenum Press, New York

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Bland, J. (1980). The Clinical Implications of Lipid Antioxidant Nutrition. In: Brewster, M.A., Naito, H.K. (eds) Nutritional Elements and Clinical Biochemistry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3168-1_6

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  • DOI: https://doi.org/10.1007/978-1-4613-3168-1_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3170-4

  • Online ISBN: 978-1-4613-3168-1

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