Skip to main content
SpringerLink
Log in

Vitamin A and Retinol Binding Protein Alterations in Disease

  • Chapter
Nutritional Elements and Clinical Biochemistry

  • 122 Accesses

Abstract

A lipid-soluble compound which is essential for life and present in egg yolk, was first described by Stepp (1909). A similar compound was later found in butterfat, egg yolk, and cod liver oil and was named “fat soluble A” by McCollum and Davies (1913, 1915) to distinguish it from essential water-soluble nutrients, which they called “water soluble B”. The “fat-soluble A” factor was capable of preventing xerophthalmia (McCollum and Simmonds, 1917) and night blindness (Fridericia and Holm, 1925). Drummond (1920) named the active lipid “vitamin” A.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Anonymous. 1966. Vitamin A and lysosomes. Nutrition Reviews 24:240.

    Article  Google Scholar 

  • Anton, E. and Brandes, D., 1968, Lysosomes in mice mammary tumors treated with cyclophosphamide. Distribution related to the course of the disease. Cancer 21:483.

    Article  Google Scholar 

  • Arens, J.F. and Van Drop, D.A., 1946, Synthesis of some compounds possessing vitamin A activity. Nature (London) 157:190.

    Article  Google Scholar 

  • Becci, P.J., Thompson, H.J., Grubbs, C.J., Squire, R.A., Brown, C.C., Sporn, M.B. and Moon, R.C., 1978, Inhibitory effects of 13-cis-retinoic acid on urinary bladder carcinogenesis induced in C57BL/6 mice by N-butyl-N-(4-hydroxybutyl)-nitrosamine. Cancer Res. 38:4463.

    Google Scholar 

  • Bollag, W., 1971, Therapy of chemically induced skin tumors of mice with vitamin A palmitate and vitamin A acid. Experientia 37:90.

    Article  Google Scholar 

  • Bollag, W. and Ott, F., 1971, Vitamin A-Sawie in der Tumortherapie: Lokalbehandlung von Prakanzerosen und Basalzell-karzinomen der Haut mit Vitamin A-Sawre. Schweiz. Med.Wochenschr. 101:17.

    Google Scholar 

  • Bollag, W., 1972, Prophylaxis of chemically induced benign and malignant epithelial tumors by vitamin A acid (retinoic acid). Eur. J.Cancer 8:689.

    Article  Google Scholar 

  • Chu, E.W. and Malmgren, R.A., 1965, An inhibitory effect of vitamin A on the induction of tumors of forestomach and cervix in the Syrian golden hamster by carcinogenic poly-cyclic hydrocarbons. Cancer Res. 25:884.

    Google Scholar 

  • Cohen, M.H. and Carbone, P.P., 1972, Enhancement of the antitumor effects of 1,3-bis-(2-chloroethyl)-1-nitrosourea and cyclophosphamide by vitamin A. J. Nat. Cancer Inst. 48:921.

    Google Scholar 

  • Cohen, S.M., Wittenberg, J.F. and Bryan, G.T., 1976, Effects of avitaminosis A and hypervitaminosis A on urinary bladder carcinogenicity of N- 4-(5-Nitro-2-furyl)-2-thiazolyl formamide. Cancer Res. 36:2334.

    Google Scholar 

  • Cone, M.V. and Nettesheim, P., 1973, Effects of vitamin A on 3-methylcholanthrene-induced squamous metaplasias and early tumors in the respiratory tract of rats. J. Natl. Cancer Inst. 50:1599.

    Google Scholar 

  • Davies, R.E., 1967, Effect of vitamin A on 7,12-dimethyl-benzanthracene-induced papilloma in rhino mouse skin. Cancer Res. 27:237.

    Google Scholar 

  • DeLuca, L.M., Silverman-Jones, C.S. and Barr, R.M., 1975, Biosynthetic studies on mannolipids and mannoproteins of normal and vitamin A-depleted hamster livers. Biochem. Biophys. Acta 409:342.

    Google Scholar 

  • Drummond, J.C., 1920, The nomenclature of the so called accessory food factors (vitamins). Biochem. J. 14:660.

    Google Scholar 

  • Cohen, S.M., Wittenberg, J.F. and Bryan, G.T., 1976, Effects of avitaminosis A and hypervitaminosis A on urinary bladder carcinogenicity of N- 4-(5-Nitro-2-furyl)-2-thiazolyl formamide. Cancer Res. 36:2334.

    Google Scholar 

  • Cone, M.V. and Nettesheim, P., 1973, Effects of vitamin A on 3-methylcholanthrene-induced squamous metaplasias and early tumors in the respiratory tract of rats. J. Natl. Cancer Inst. 50:1599.

    Google Scholar 

  • Davies, R.E., 1967, Effect of vitamin A on 7,12-dimethyl-benzanthracene-induced papilloma in rhino mouse skin. Cancer Res. 27:237.

    Google Scholar 

  • DeLuca, L.M., Silverman-Jones, C.S. and Barr, R.M., 1975, Biosynthetic studies on mannolipids and mannoproteins of normal and vitamin A-depleted hamster livers. Biochem. Biophys. Acta 409:342.

    Google Scholar 

  • Drummond, J.C.,1920, The nomenclature of the so called accessory food factors (vitamins). Biochem. J. 14:660.

    Google Scholar 

  • Evans, H.M. and Bishop, K.S., 1922, On an invariable and characteristic disturbance of reproductive function in animals reared on a diet poor in fat soluble vitamin A. Anat. Rec. 23:17.

    Google Scholar 

  • Evans, H.M., 1928, The effects of inadequate vitamin A on the sexual physiology of the female. J. Biol. Chem. 77:651.

    Google Scholar 

  • Evans, H.M., 1932, Testicular degeneration due to inadequate vitamin A in cases where E is adequate. Am. J. Physiol. 99:477.

    Google Scholar 

  • Fidge, N.H. and Goodman, D.S., 1968, The enzymatic reduction of retinal to retinol in rat intestine. J. Biol. Chem. 243:4372.

    Google Scholar 

  • Fridericia, L.S. and Holm, E., 1925, Relation between night blindness and malnutrition-influence of deficiency of fat-soluble A vitamin in the diet on the visual purple in the eyes of rats. Am. J. Physiol. 73:63.

    Google Scholar 

  • Goodman, D.S., Huang, H.S. and Shiratori, T., 1965, Tissue distribution and metabolism of newly absorbed vitamin A in the rat. J. Lipid Res. 6:390.

    Google Scholar 

  • Goodman, D.S., Huang, H.S. and Shiratori, T., 1966, Mechanism of the biosynthesis of vitamin A from β-carotene. J. Biol. Chem. 241:1929.

    Google Scholar 

  • Goodman, D.S. and Olson, J.S., 1969, In: Methods in Enzymology. Vol. XV. Steroids and Terpenoids. (R.B. Claxton, ed.) New York, Academic.

    Google Scholar 

  • Grubbs, C.J., Moon, R.A., Squire, R.A., Farrow, G.M., Stinson, S.F., Goodman, D.G., Brown, C.C., Spron, B.M., 1979, 13-cis-Retinoic acid: Inhibition of bladder carcinogenesis induced in rats by N-butyl-N-(4-hydroxylbutyl) nitrosamine. Science 198:743.

    Article  Google Scholar 

  • Heller, J., 1975, Interactions of plasma retinol-binding protein with its receptor. Specific binding of bovine and human retinol-binding protein to pigment epithelium cells from bovine eyes. J. Biol. Chem. 250:3613.

    Google Scholar 

  • Holmes, H.N. and Corbett, R.E., 1937, The isolation of crystalline vitamin A. J. Am. Chem. Soc. 59:2042.

    Article  Google Scholar 

  • Howell, J.M., Thompson, J.N. and Pitt, G.A.J., 1963, Histology of the lesions produced in the reproductive tract of animals fed a diet deficient in vitamin A alcohol but containing vitamin A acid. I. The male rat. J. Reprod. Fertil. 5:159.

    Article  Google Scholar 

  • Howell, J.M. and Thompson, J.N., 1967a, Lesions associated with the ataxia in vitamin A deficient chicks, Br. J. Nutr. 21:741.

    Article  Google Scholar 

  • Howell, J.M. and Thompson, J.N., 1967b, Observations on the lesions in vitamin A deficient adult fowls with particular reference to changes in bone and central nervous system. Br. J. Exp. Pathol. 48:450.

    Google Scholar 

  • Howell, J.M., Thompson, J.N. and Pitt, G.A.J., 1967, Changes in the tissues of guinea-pigs fed on a diet free from vitamin A but containing methyl retinoate. Br. J. Nutr. 21:37.

    Article  Google Scholar 

  • Huang, H.S. and Goodman, D.S., 1965, Vitamin A and carotenoids. I. Intestinal absorption and metabolism of 14C-labeled vitamin A alcohol and β-carotene in the rat. J. Biol. Chem. 240:2839.

    Google Scholar 

  • Isler, O., Huber, W., Ronco, A. and Koffler, M., 1947, Synthese des Vitamin A. Helv. Chim. Acta 30:1911.

    Article  Google Scholar 

  • Isler, O., Klaui, H. and Solms, U., 1967, Vitamin A. III. Industrial preparation and production. In the Vitamins (W.H. Sebrell, Jr. and R.S. Harris, eds.) p. 101. Academic Press, New York.

    Google Scholar 

  • Isler, O., Solms, U. and Wursch, J., 1970, In: Fat Soluble Vitamins (R.A. Morton, ed.) p. 99. Pergamon Press, Oxford.

    Google Scholar 

  • IUPAC. 1960, Commission on the nomenclature of biological chemistry. J. Am. Chem. Soc. 82:5581.

    Google Scholar 

  • IUPAC-IUB. 1966, Commission on biochemical nomenclature, tenative rules. J. Biol. Chem. 241:2987.

    Google Scholar 

  • Kanai, M., Raz, A. and Goodman, D.S., 1968, Retinol-binding protein: The transport protein for Vitamin A in human plasma. J. Clin. Invest. 47:2025.

    Article  Google Scholar 

  • Karrer, P., Helfenstein, A., Wehrli, H. and Wehstein, A., 1930, Pflanzenfarbstoffe. XXV. Ueber die Konstitution des Lycopins and Corotins. Helv. Chim. Acta 13:1084.

    Article  Google Scholar 

  • Karrer, P., Morf, R. and Schopp, K., 1931, Zur Kenntis des Vitamins-A aus Fischtranen. Helv. Chim. Acta 14:1036.

    Article  Google Scholar 

  • Lasnitzki, I. and Goodman, D.S., 1974, Inhibition of the effects of methylcholanthrene on mouse prostate in organ culture by vitamin A and its analogs. Cancer Res. 34:1564.

    Google Scholar 

  • Levij, I.S. and Polliack, A., 1968, Potentiating effect of vitamin A on 9,10 dimethyl 1-2 benzanthracene carcinogenesis in the hamster cheek pouch. Cancer 22:300.

    Article  Google Scholar 

  • Levine, N.S., Salisbury, R.E., Seifter, E., Walker, H.L., Mason, A.D., Jr., and Pruitt, B.A., Jr., 1975, Effect of vitamin A on tumor development in burned, unburned and glucocorticoid-treated mice inoculated with an oncogenic virus. Experientia 15:1309.

    Article  Google Scholar 

  • Lotan, R. and Nicolson, G.L., 1977, Inhibitory effects of retinoic acid or retinyl acetate on the growth of untrans-formed, transformed, and tumor cells in vitro, 59:1717.

    Google Scholar 

  • Mason, K.E., 1932, Differences in testes injury and repair after vitamin A deficiency, vitamin E deficiency and inanition. Am. J. Anat. 51:153.

    Google Scholar 

  • Mason, K.E., 1933, Differences in testes injury and repair after vitamin A deficiency and inanition. Am. J. Anat. 52:153.

    Article  Google Scholar 

  • Mayer, H. and Isler, O., 1971, Total synthesis of carotenoids. In: Carotenoids (O. Isler, ed.) p. 328. Binkhauser. Verlog, Basel.

    Google Scholar 

  • McCollum, E.V. and Davies, M., 1913, The necessity of certain lipids on the diet during growth. J. Biol. Chem. 15:167.

    Google Scholar 

  • McCollum, E.V. and Davies, M., 1915. The nature of the dietary deficiency of rice. J. Biol. Chem. 23:181.

    Google Scholar 

  • McCollum, E.V. and Simmonds, N., 1917, A biological analysis of pellagra producing diet. II. The minimum requirements of the two unidentified dietary factors for maintenance as contrasted with growth. J. Biol. Chem. 32:181.

    Google Scholar 

  • McMichael, H., 1965, Inhibition of growth of Shope rabbit papilloma by hypervitaminosis A. Cancer Res. 25:947.

    Google Scholar 

  • Mellanby, E., 1944, Nutrition in relation to bone growth and the nervous system. Proc. R. Soc. London Ser. B. 132:28.

    Article  Google Scholar 

  • Moon, R.C., Grubbs, C.J. and Spron, M.B., 1976, Inhibition of 7, 12-dimethylbenzanthracene-induced mammary carcinogenesis by retinyl acetate. Cancer Res 36:2626.

    Google Scholar 

  • Morton, R.A., 1944, Chemical aspects of the visual process. Nature (London) 153:69.

    Article  Google Scholar 

  • Morton, R.A. and Goodwin, T.W., 1944, Preparation of retinene “in vitro”. Nature (London) 153:405.

    Article  Google Scholar 

  • Ong, E.D. and Chytil, F., 1976, Presence of retinol and retinoic acid binding proteins in experimental tumors. Cancer Lett. 2:25.

    Article  Google Scholar 

  • Ong, D.E. and Chytil, F., 1979, Immunochemical comparison of vitamin A binding proteins in rat. J. Biol. Chem. 254:8733.

    Google Scholar 

  • Rask, L. and Peterson, P.A., 1976, In vitro uptake of vitamin A from the retinol-binding plasma protein to mucosal epithelial cells from monkey’s small intestine. J. Biol. Chem. 251:6360.

    Google Scholar 

  • Redgrave, T.G., 1970, Formation of cholesteryl ester-rich particulate lipid during metabolism of chylomicrons, J. Clin. Invest 49:465.

    Article  Google Scholar 

  • Rowe, N.H. and Gorlin, R.J., 1959, The effect of vitamin A deficiency upon experimental oral carcinogenesis. J. Dent. Res. 38:72.

    Article  Google Scholar 

  • Russell, R.M., Morrison, S.A., Smith, F.R., Oaks, E.V. and Carney, E.A., 1978, Vitamin A reversal of abnormal dark adaptation in cirrhosis. Study of effects on the plasma retinol transport system. Ann. Int. Med. 88:622.

    Google Scholar 

  • Saffiotti, U., Montesano, R., Sella-Kumar, A.R., and Borg, S.A., 1967, Experimental cancer of the lung: Inhibition by vitamin A of the induction of tracheobronchial squamous metaplasia and squamous cell tumors. Cancer 20:857.

    Article  Google Scholar 

  • Schwieter, U. and Isler, O., 1967, Vitamin A. II. Chemistry, In: The vitamins, Vol. I (W.H. Sebrell, Jr. and R.S. Harris, eds.) Academic Press, New York.

    Google Scholar 

  • Shamberger, R.J., 1971, Inhibitory effect of vitamin A on carinogenesis. J. Nat. Cancer Inst. 48:1491.

    Google Scholar 

  • Smith, F.R. and Goodman, D.S., 1971, The effect of disease of the liver, thyroid, kidneys on the transport of vitamin A in human plasma. J. Clin. Invest. 50:2426.

    Article  Google Scholar 

  • Smith, W.E., Yazdi, E. and Miller, L., 1972, Carcinogenesis in pulmonary epithelia in mice on different levels of vitamin A. Environ. Res. 5:152.

    Article  Google Scholar 

  • Smith, D.M., Rogers, A.E., Herndon, B.J. and Newberne, P.M., 1975a, Vitamin A (retinyl acetate) and benzopyrene-induced respiratory tract carcinogenesis in hamsters fed a commercial diet. Cancer Res. 35:11.

    Google Scholar 

  • Smith, D.M., Rogers, A.E. and Newberne, P.M., 1975b, Vitamin A and benzopyrene carcinogenesis in the respiratory tract of hamsters fed a semi-synthetic diet. Cancer Res 35:1485.

    Google Scholar 

  • Sporn, M.B., Dunlop, N.M., Newton, D.L. and Henderson, W.R., 1976, Relationship between structure and activity of retinoids. Nature 263:110.

    Article  Google Scholar 

  • Steenbock, H., Sell, M.T., Nelson, E.M. and Buell, M.V., 1921, The fat-soluble vitamin. Proc. Am. Soc. Biol. Chem. J. Biol. Chem. 46: Proc. XXXII.

    Google Scholar 

  • Stepp, W., 1909, Versuche uber Futterung mit lipoid freier Ernahrung. Biochem. Ztschr. 22:452.

    Google Scholar 

  • Vahlquist, A., Peterson, P.A. and Wibell, L., 1973, Metabolism of the vitamin A transporting protein complex. I. Turnover studies in normal persons and in patients with chronic renal failure. Eur. J. Clin. Invest. 3:352.

    Article  Google Scholar 

  • Verma, A.K., Rice, H.M., Shapas, B.G. and Boutwell, R.K., 1978, Inhibition of 12-0-tetradecanoylphorbol-13 acetate-induced ornithine decarboxylase activity in mouse epidermis by vitamin A analogs (retinoids). Cancer Res. 38:793.

    Google Scholar 

  • Wald, G., 1935a, Vitamin A in eye tissue. J. Gen. Physiol. 18:905.

    Article  Google Scholar 

  • Wald, G., 1935b, Carotenoids and visual cycle. J. Gen. Physiol. 19:351.

    Article  Google Scholar 

  • Wald, G., 1935c, Pigments of the bull frog retina. Nature (London) 136:832.

    Article  Google Scholar 

  • Wald, G., 1936c, Pigments in the retina. I. J. Gen. Physiol. 19:781.

    Article  Google Scholar 

  • Wald, G., 1936b, Pigments in the retina. II. J. Gen. Physiol. 20:45.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biochemistry, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio, 44106, USA

    Raymond J. Shamberger Ph.D.

Authors
  1. Raymond J. Shamberger Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Departments of Pathology, Biochemistry, and Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

    Marge A. Brewster

  2. Metabolic Laboratory, Arkansas Children’s Hospital, Little Rock, Arkansas, USA

    Marge A. Brewster

  3. Department of Biochemistry, Division of Laboratory Medicine, Department of A therosclerosis and Thrombosis Research, Division of Research, Cleveland Clinic Foundation, Cleveland, Ohio, USA

    Herbert K. Naito

  4. Department of Chemistry, Cleveland State University, Cleveland, Ohio, USA

    Herbert K. Naito

Rights and permissions

Reprints and permissions

Copyright information

© 1980 Plenum Press, New York

About this chapter

Cite this chapter

Shamberger, R.J. (1980). Vitamin A and Retinol Binding Protein Alterations in Disease. In: Brewster, M.A., Naito, H.K. (eds) Nutritional Elements and Clinical Biochemistry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3168-1_4

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-3168-1_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3170-4

  • Online ISBN: 978-1-4613-3168-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation