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Vitamin A and Retinol Binding Protein Alterations in Disease

  • Raymond J. Shamberger

Abstract

A lipid-soluble compound which is essential for life and present in egg yolk, was first described by Stepp (1909). A similar compound was later found in butterfat, egg yolk, and cod liver oil and was named “fat soluble A” by McCollum and Davies (1913, 1915) to distinguish it from essential water-soluble nutrients, which they called “water soluble B”. The “fat-soluble A” factor was capable of preventing xerophthalmia (McCollum and Simmonds, 1917) and night blindness (Fridericia and Holm, 1925). Drummond (1920) named the active lipid “vitamin” A.

Keywords

Retinoic Acid Retinol Binding Protein Syrian Golden Hamster Night Blindness Retinyl Palmitate 
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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • Raymond J. Shamberger
    • 1
  1. 1.Department of BiochemistryThe Cleveland Clinic FoundationClevelandUSA

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