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Some Manifestations of Malabsorption in Disease

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Nutritional Elements and Clinical Biochemistry

Abstract

The term malabsorption has come to include both defective digestion and absorption. All ingested nutrients, i.e., fat, carbohydrate, proteins, minerals, H2O, and vitamins, normally enter the body via the gastrointestinal tract. It must be remembered that the absorbing surface of the digestive tract is not a one-way street. Therefore, in addition to oral food intake, a significant load of ‘endogenous nutrients’ is added to the intestinal contents of the alimentary canal. Complex nutrient molecules of both exogenous and endogenous origin undergo stepwise degradation to absorbable form and are transported into the intestinal cell also in a stepwise manner. Consideration of these steps and appreciation that absorbed nutrients exit from the intestinal cell, via either the portal vein or the lymphatic system, are essential to understanding malabsorption.

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References

  • Asatoor, A. M., Cheng, B., Edwards, D. G., Lant, A. F., Matthews, D. M., Milne, M. D., Navab, F., and Richards, A. J., 1970, Intestinal absorption of two dipeptides in Hartnup disease, Gut, 11:380.

    Article  Google Scholar 

  • Barr, R. G., Levine, M. D., and Watkins, J. B., 1979, Recurrent abdominal pain of childhood due to lactose intolerance, N. Eng. J. Med., 300:1449.

    Article  Google Scholar 

  • Battle, W. M., Rubin, M. R., Cohen, S. and Snape, W. J., Jr., 1979, Gastrointestinal-motility dysfunction in amyloidosis, N. Eng. J. Med., 301:24.

    Article  Google Scholar 

  • Berg, N. O., Dahlqvist, A., Lindberg, T., and Studnitz, W. V., 1969, Severe familial lactose intolerance - a gastrogen disorder?, Acta Paediat. Scand., 58:525.

    Article  Google Scholar 

  • Brandt, L. J., Bernstein, L. H., Efron, F., and Wagle, A., 1975, Vitamin B12 analogue production in the experimental blind loop, (abstract), Gastroenterology, 68:863.

    Google Scholar 

  • Brant, L. J., Bernstein, L. H., and Wagle, A., 1977, Production of vitamin B12 analogues in patients with small-bowel bacterial overgrowth, Ann. Intern. Med., 87:546.

    Google Scholar 

  • Craft, I. L., Geddes, D., Hyde, C W., Wise, I. J., and Matthews, D. M., 1968, Absorption and malabsorption of glycine and glycine peptides in man, Gut, 9:425.

    Article  Google Scholar 

  • di Sant’Agnese, P. A. and Davis, P. B., 1979, Cystic fibrosis in adults - 75 cases and a review of 232 cases in the literature, Amer. J. Med., 66:121.

    Article  Google Scholar 

  • Donaldson, R. M., Jr., Crohn’s disease of the small bowel in “Sleisenger and Fordtran Gastrointestinal Disease”, 1978, pp. 1052–1076, W. B. Saunders, Philadelphia.

    Google Scholar 

  • Enger, E. and Blegan, E. M., 1964, The relationship between endogenous creatinine clearance and serum creatinine in renal failure, Scand. J. Clin. Lab. Invest., 16:273.

    Article  Google Scholar 

  • Gracey, M., 1979, The contaminated small bowel syndrome: pathogenesis, diagnosis and treatment, Amer. J. Clin. Nutr., 32:234.

    Google Scholar 

  • Jepson, J. B., in “The Metabolic Basis of Inherited Disease”, Eds: J. B. Stanbury, J. B. Wyngaarden and D. S. Fredrickson, pp. 1486–1503, third edition, McGraw-Hill, New York, 1972.

    Google Scholar 

  • Jones, J. D. and Burnett, P. C., 1972, Implication of creatinine and gut flora in the uremic syndrome: induction of “creatininase” in colon contents of the rat by dietary creatinine, Clin. Chem., 18:280.

    Google Scholar 

  • Jones, J. D. and Burnett, P. C., 1974, Creatinine metabolism in humans with decreased renal function: creatinine deficit, Clin. Chem., 20:1204.

    Google Scholar 

  • Jones, J. D. and Burnett, P. C., 1975, Creatinine metabolism and toxicity, Kidney Internatl., 7:S294.

    Google Scholar 

  • Jones, J. D., Steige, H., and Logan, G. B., 1979, Variations of sweat sodium values in children and adults with cystic fibrosis and other diseases, Mayo Clin. Proc., 45:768.

    Google Scholar 

  • Kahn, I. J., Jeffries, G. H., and Sleisenger, M. H., 1966, Malabsorption in intestinal sclerodema. Correction by antibiotics, N. Eng. J. Med., 274:1339.

    Article  Google Scholar 

  • Katz, A. J. and Grand, R. J., 1979, All that flattens are not “sprue”, Gastroenterology, 76:375.

    Google Scholar 

  • Kolhouse, J. F., Kondo, H., Allne, N. C., Podell, E., and Allen, R. H., 1978, Cobalamin analogues are present in human plasma and can mask cobalamin deficiency because current radioisotope dilution assays are not specific for true cobalamin, N. Eng. J. Med., 299:785.

    Article  Google Scholar 

  • Kyle, R. A. and Bayrd, E. D., 1975, Amyloidosis: a review of 236 cases, Medicine, 54:271.

    Article  Google Scholar 

  • Lifshitz, F., 1966, Congenital lactase deficiency, J. Peds., 69:229.

    Article  Google Scholar 

  • Menzies, I. S. and Seakins, J. W. T., 1969, Sugars, in “Chromatographic and Electrophoretic Techniques”, Vol. 1, 3rd edition, (I. Smith, ed.), pp. 310–329, Interscience Publications, New York.

    Google Scholar 

  • Milne, M. D., Asatoor, A. M., Edwards, K. D. G., and Loughridge, L. W., 1961, The intestinal absorption defect in cystinuria, J. Br. Soc. Gastroenter., 2:323.

    Google Scholar 

  • Newcomer, A. D., McGill, D. G., Thomas, P. J., and Hormann, A. F., 1975, Prospective comparison of indirect methods for detecting lactase deficiency, N. Eng. J. Med., 293:1232.

    Article  Google Scholar 

  • Phillips, S. F., 1972, Diarrhea: a current view of the pathophysiology, Gastroenterology, 63:495.

    Google Scholar 

  • Shimoda, S. S., Saunders, D. R., and Rubin, C. E., 1968, The Zollinger-Ellison syndrome with steatorrhea. Mechanisms of fat and vitamin B12 malabsorption, Gastroenterology, 55:705.

    Google Scholar 

  • Simenhoff, M. L., Saukkonen, J. J., Burke, J. F., Wesson, L. G., and Schaedler, R. W., 1976, Amine metabolism and the small bowel in uraemia, Lancet, 2:818.

    Article  Google Scholar 

  • Soong, C. S., Thompson, T. B., Poley, J. R., and Hess, D. R., 1972, Hydroxy fatty acids in human diarrhea, Gastroenterology, 63:748.

    Google Scholar 

  • Sorenson, L. B., 1959, Degradation of uric acid in man, Metabol. Clin. and Exper., 8:687.

    Google Scholar 

  • Teem, M. V. and Phillips, S. F., 1972, Perfusion of the hamster jejunum with conjugated and unconjugated bile acids: inhibition of water absorption and effects on morphology, Gastroenterology, 62:261.

    Google Scholar 

  • Walser, M. and Bodenlos, L. J., 1959, Urea metabolism in man, J. Clin. Invest., 38:1617.

    Article  Google Scholar 

  • Wood, W. J., Archer, R., Schaeffer, J. W., Stevens, C., and Griffen, Jr., W. O., 1970, Coexistence of regional enteritis and carcinoid tumor, Gastroenterology, 59:265.

    Google Scholar 

  • Younoszai, M. K., Sapario, R. S., and Laughlin, M., 1978, Maturation of jejunum and ileum in rats, J. Clin. Invest., 62:271.

    Article  Google Scholar 

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© 1980 Plenum Press, New York

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Jones, J.D., Jones, M.A. (1980). Some Manifestations of Malabsorption in Disease. In: Brewster, M.A., Naito, H.K. (eds) Nutritional Elements and Clinical Biochemistry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3168-1_13

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  • DOI: https://doi.org/10.1007/978-1-4613-3168-1_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3170-4

  • Online ISBN: 978-1-4613-3168-1

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