Skip to main content
  • 129 Accesses

Abstract

Many of the nutritional disorders of infants and children such as rickets, scurvey, marasmus and kwashiorkor have been recognized by their clinical and laboratory findings. Less well appreciated are the abnormalities in growth due to major disturbances in macronutrient intake, absorption and/or utilization that result in failure-to-thrive at one end of the spectrum or obesity at the other end. The origins of these growth abnormalities related to nutrition are frequently manifest in-utero or in infancy and may be corrected by appropriate diagnosis and intervention. The purpose of this article is to highlight some clinical examples of failure-to-thrive and to contrast these with excessive growth and obesity.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Battalgia, F. C. and Lubchenco, L. O., 1967, A practical classification of newborn infants by birth weight and gestational age, J. Pediatr., 71:159.

    Article  Google Scholar 

  • Burd, I., 1976, “Placental insufficiency syndromes” in The Neonate (D. S. Young and J. M. Hicks, eds.), PP. 47–58, John Wiley and Sons, New York.

    Google Scholar 

  • Cheek, D. B. (ed.), 1975, Fetal and Postnatal Cellular Growth, John Wiley and Sons, New York.

    Google Scholar 

  • DuBois, S., Hill, D. E., and Beaton, H., 1979, An examination of factors believed to be associated with infantile obesity, Amer. J. Clin. Nutr., 32:1979.

    Google Scholar 

  • Elliot, K. and Knight, J., 1974, General Discussion, in Size at Birth, Ciba Foundation Symposium 27 (new series, p. 393, Associated Scientific Publishers, Amsterdam.

    Chapter  Google Scholar 

  • Gruenwald, P., 1964, Infants of low birth weight among 5,000 deliveries, Pediatrics, 334:157.

    Google Scholar 

  • Hill, E., 1976, “Insulin and fetal growth” in Diabetes and Other Endocrine Disorders During Pregnancy and in the Newborn, (M. I. New and R. H. Fiser, eds.), Alan R.Liss, Inc., New York.

    Google Scholar 

  • Hill, E., 1978, Effect of insulin on fetal growth, Sem. in Perinatol., 2(4):319.

    Google Scholar 

  • Hill, D. E., Mayes, S., DiBattista, D., Lockhart-Ewart, R., and Martin, J. M., 1977, Hypothalamic regulation of insulin release in Rhesus monkey, Diabetes, 26:726.

    Article  Google Scholar 

  • Karn, M. N. and Penrose, L. S., 1951, Birth weight and gestation time in relation to maternal age, parity and infant survival, Ann. Engen., 16:147.

    Article  Google Scholar 

  • Lockhart-Ewart, R. B., Mok, C., and Martin, J. M., 1976, Neuroendocrine control of insulin secretion, Diabetes, 25:96.

    Article  Google Scholar 

  • Martin, J. M., Konijnendijk, W., and Bouman, P. R., 1974, Insulin and growth hormone secretion in rats with ventromedial hypothalamic lesions maintained on restricted food intake, Diabetes, 23:203.

    Google Scholar 

  • Martin, J. M., Mok, C. C., Penfold, J., Howard, N. J., and Crowne, D., 1974, Hypothalamic stimulation of insulin release, J. Endocrinol., 58:681.

    Article  Google Scholar 

  • McBurney, R. D., 1947, The undernourished full-term infant, West. J. Surg. Obstet. Gynecol., 5:363.

    Google Scholar 

  • Naeye, R. L., 1965, Infants of diabetic mothers. A quantitative morphologic study, Pediatrics, 35:980.

    Google Scholar 

  • Osler, M. and Pederson, J., 1960, The body composition of newborn infants of diabetic mothers, Pediatrics, 26:985.

    Google Scholar 

  • Polani, P. E., 1974, “Chromosomal and other genetic influences on birth weight variation” in Size at Birth, Ciba Founcation Symposium 27 (new series), pp. 127–164, Associated Scientific Publishers, Amsterdam.

    Google Scholar 

  • Sherwood, W. G., Chance, G. W., Hill, D. E., 1974, A new syndrome of pancreatic agenesis. The role of insulin and glucagon in somatic and cell growth. Pediatr. Res., 8:360 (Abstract)

    Article  Google Scholar 

  • Simmons, A., 1976, “Normal physiological development of the fetus” in The Neonate (D. S. Young and J. M. Hicks, eds.), pp. 27– 38, John Wiley and Sons, New York.

    Google Scholar 

  • Simmons, M. A., Meschia, G., Makowski, E. L., and Battaglia, F. C., 1974, Fetal metabolic response to maternal starvation, Pediatr. Res., 8:830.

    Google Scholar 

  • Stein, Z. A., Susser, M. W., 1975, The Dutch famine, 1944/45, and the reproductive process: I. Effects on six indices at birth, Pediatr. Res., 9:70.

    Google Scholar 

  • Stein, Z., Susser, M. and Rush, D., 1978, Prenatal nutrition and birth weight: experiments and quasi-experiments in the past decade, J. Repro. Med., 21(5):287.

    Google Scholar 

  • Usher, R., and McLean, F., 1969, Intrauterine growth of live-born Caucasian infants at sea level: standards obtained from measurements in 7 dimensions of infants born between 25 and 44 weeks of gestation, J. Pediatr., 72:901.

    Google Scholar 

  • Winick, M., 1972, Nutrition and Development, John Wiley and Sons, New York.

    Google Scholar 

  • Worley, R. J., Everett, R. B., MacDonald, P. C. and Grant, N. F., 1975, Placental clearance of dehydroisoandrosterone sulfate and pregnancy outcome in three categories of hospitalized patients with pregnancy induced hypertension, Gynceol. Invest., 6:28.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1980 Plenum Press, New York

About this chapter

Cite this chapter

Hill, D.E. (1980). Clinical Correlates in Nutritional Disease. In: Brewster, M.A., Naito, H.K. (eds) Nutritional Elements and Clinical Biochemistry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3168-1_1

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-3168-1_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3170-4

  • Online ISBN: 978-1-4613-3168-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics