Immune Responses of Hamsters and Humans with Antibiotic-Associated Colitis

  • Joseph Silva
  • Rodney Lusk
  • Robert Fekety
  • Kenneth Wilson
  • Donald Batts
  • David Mason
  • Daniel Spratt

Abstract

The Golden Syrian hamster has served as a model for antibiotic-associated colitis of humans and has been instrumental in discovering its pathogenesis (4,18). Toxigenic Clostridium difficile have been implicated as the major cause of antibiotic-associated colitis (AAC) in both hamsters and humans (5,10,20). While clindamycin first focused attention on this lesion, many other antibiotics have been implicated subsequently following either parenteral or oral administrations. AAC also varies greatly in its clinical presentation in humans and in its geographic distribution (17,23).

Keywords

Toluene Diarrhea Cardiol Vancomycin Fibrinogen 

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Literature Cited

  1. 1.
    Abrams, G.D., M. Alio, G. Rifkin, R. Fekety, and J. Silva. 1978. Mucosal damage due to Clostridium difficile toxin: Similarity to clindamycin-associated typhlitis. The 18th Interscience Conference on Antimicrobial Agents and Chemotherapy. Atlanta, Ga., October.Google Scholar
  2. 2.
    Alio, M., J. Silva, R. Fekety, G. Rifkin, and H. Waskin. 1979. Prevention of clindamycin-induced colitis in hamsters by Clostridium sordellii antitoxin. Gastroent. 76: 351.Google Scholar
  3. 3.
    Axelsen, N.H., J. Kroll, and B. Weeke. 1973. A manual of quantitative Immunoelectrophoresis, methods and applications. Scand. J. Immunol. 2 (Suppl. 1 ) Universitetsforlaget, Oslo.Google Scholar
  4. 4.
    Bartlett, J.G., A.B. Onderdonk, R.L. Cisneros, and D.L. Kasper. 1977. Clindamycin-associated colitis due to a toxin-producing species of Clostridium in hamsters. J. Infect. Dis. 136: 70.Google Scholar
  5. 5.
    Bartlett, J.G., T.W. Chang, M. Gurwith, S.L. Gorbach, and A.B. Onderdonk. 1978. Antibiotic-associated pseudomembranous colitis due to toxin-producing Clostridia. New Engl. J. Med. 298: 531.PubMedCrossRefGoogle Scholar
  6. 6.
    Browne, R.A., R. Fekety, J. Silva, D.I. Boyd, C.O. Work, and G.D. Abrams. 1977. The protective effect of vancomycin on clindamycin-induced colitis in hamsters. Johns Hopkins Med. J. 141: 183.PubMedGoogle Scholar
  7. 7.
    Dykes, P.W. 1972. Immunology of Crohn1s disease. Gastroent. 1: 349.Google Scholar
  8. 8.
    Fekety, R. 1979. Prevention and treatment of antibiotic-associated colitis. Microbiology, pp. 276–279.Google Scholar
  9. 9.
    George, W.L., V.L, Sutter, and S.M. Finegold. 1978. Toxigenicity and antimicrobial susceptibility of Clostridium difficile, a cause of antimicrobial agent-associated colitis. Curr. Microbiol. 1: 55.Google Scholar
  10. 10.
    George, W.L., V.L. Sutter, E.J.C. Goldstein, S.L. Ludwig, and S.M. Finegold. 1978. Aetiology of antimicrobial-agent- associated colitis. Lancet l: 802.Google Scholar
  11. 11.
    George, W.L., V.L. Sutter, D. Citron, and S.M. Finegold. 1979. Selective and differential medium for isolation of Clostridium difficile. J. Clin. Microbiol. 9: 214.PubMedGoogle Scholar
  12. 12.
    Gerfo, P.L., J. Krupey, and H.J. Hansen. 1971. Demonstration of an antigen common to several varieties of neoplasia. Assay using zirconyl phosphate gel. New Engl. J. Med. 285: 138.PubMedCrossRefGoogle Scholar
  13. 13.
    Hafiz, S., M.G. McEntergart, R.S. Morton, and S.A. Waitkins. 1975. Clostridium difficile in the urogenital tract of males and females. Lancet 1: 420.Google Scholar
  14. 14.
    Harvie, N., S. Ellis, D. Mason, M. Alio, G. Rifkin, J. Silva, and R, Fekety. 1978. Isolation and purification of a Clostridium difficile toxin that causes colitis in the Syrian hamster. The 18th Interscience Conference on Antimicrobial Agents and Chemotherapy. Atlanta, Ga., October.Google Scholar
  15. 15.
    Keighley, M.R.B, D.W. Burdon, Y. Arabi, J. Alexander-Williams, H. Thompson, D. Youngs, M. Johnson, S. Bentley, R.H. George, and G.A.G. Mogg. 1978. Randomised controlled trial of vancomycin for pseudomembranous colitis and postoperative diarrhea. Br. Med. J. 2: 1667.PubMedCrossRefGoogle Scholar
  16. 16.
    Kraft, S.C., and J.B. Kirsner. 1971. Immunological apparatus of the gut and inflammatory bowel disease. Gastroent. 60: 922.Google Scholar
  17. 17.
    Lusk, R.H., F.R. Fekety, J. Silva, T. Bodendorfer, B.J. Devine, H. Kawanishi, L. Korff, D. Nakauchi, S. Rogers, and S.B. Siskin. 1977. Gastrointestinal side effects of clindamycin and ampicillin therapy. J. Infect. Dis. 135 ( Suppl. ): Sill.Google Scholar
  18. 18.
    Lusk, R.H., R. Fekety, J. Silva, R.A. Browne, D.H. Ringler, and G.D, Abrams. 1978. Clindamycin-induced enterocolitis in hamsters. J. Infect. Dis. 137: 464.PubMedCrossRefGoogle Scholar
  19. 19.
    Mancini, G., A.O. Carbonara, and J.F. Heremans. 1965. Immunochemical quantitation of antigens by single radial immunodif fusion. Immunochemistry 2: 235.PubMedCrossRefGoogle Scholar
  20. 20.
    Rifkin, G.D., R. Fekety, J. Silva, and R.B. Sack. 1977. Antibiotic-induced colitis: implication of a toxin neutralized by Clostridium sordellii antitoxin. Lancet 2: 1103.PubMedCrossRefGoogle Scholar
  21. 21.
    Rifkin, G.D., R. Fekety, and J. Silva. 1978. Neutralization by Clostridium sordellii antitoxin of toxins implicated in clindamycin-induced cecitis in the hamster. Gastroent, 75: 422.Google Scholar
  22. 22.
    Simon, M.R., J. Silva, D. Freier, J. Bruner, and R. Williams. 1977. Tuberculin-specific transfer factor in dogs. Infect. Immun. 18: 73.PubMedGoogle Scholar
  23. 23.
    Tedesco, F.J. 1976. Clindamycin-associated colitis. Am. J. Dig. Dis. 21: 26.PubMedCrossRefGoogle Scholar
  24. 24.
    Terasaki, P.I., M. Van Diepow, C.I. Davidson, and M.R. Mickey. 1969. Serotyping for homotransplantation XXIV heart transplantation. Amer. J. Cardiol. 24: 500.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • Joseph Silva
    • 1
  • Rodney Lusk
    • 1
  • Robert Fekety
    • 1
  • Kenneth Wilson
    • 1
  • Donald Batts
    • 1
  • David Mason
    • 1
  • Daniel Spratt
    • 1
  1. 1.Department of Internal Medicine Division of Infectious DiseasesUniversity of Michigan Medical CenterAnn ArborUSA

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