Immune Responses of Hamsters and Humans with Antibiotic-Associated Colitis

  • Joseph Silva
  • Rodney Lusk
  • Robert Fekety
  • Kenneth Wilson
  • Donald Batts
  • David Mason
  • Daniel Spratt


The Golden Syrian hamster has served as a model for antibiotic-associated colitis of humans and has been instrumental in discovering its pathogenesis (4,18). Toxigenic Clostridium difficile have been implicated as the major cause of antibiotic-associated colitis (AAC) in both hamsters and humans (5,10,20). While clindamycin first focused attention on this lesion, many other antibiotics have been implicated subsequently following either parenteral or oral administrations. AAC also varies greatly in its clinical presentation in humans and in its geographic distribution (17,23).


Stimulation Index Pseudomembranous Colitis Splenic Lymphocyte Lymphocyte Transformation Golden Syrian Hamster 
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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • Joseph Silva
    • 1
  • Rodney Lusk
    • 1
  • Robert Fekety
    • 1
  • Kenneth Wilson
    • 1
  • Donald Batts
    • 1
  • David Mason
    • 1
  • Daniel Spratt
    • 1
  1. 1.Department of Internal Medicine Division of Infectious DiseasesUniversity of Michigan Medical CenterAnn ArborUSA

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