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Comparison of the Mutagenic Effect of Ultraviolet Radiation and Chemicals in Normal and DNA-Repair-Deficient Human Cells in Culture

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Chemical Mutagens

Abstract

Interest in the development of valid short-term tests that can provide information useful for assessing environmental agents for their potential risks to the human population has increased greatly during the past decade. Because it is not feasible to conduct experiments on man himself, emphasis is necessarily placed on findings drawn from epidemiological studies carried out in retrospect. Insights into human risk are also obtained from experimental studies carried out with mammals. Within the past ten years, methods have been developed and refined for using mammalian cells in culture, including diploid human cells, to assay the mutagenic and the carcinogenic effect of environmental agents and to examine the mechanisms of mutagenesis and carcinogenesis.

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Author information

Authors and Affiliations

  1. Carcinogenesis Laboratory-Fee Hall, Department of Microbiology and Public Health and Department of Biochemistry, Michigan State University, East Lansing, Michigan, 48824, USA

    Veronica M. Maher & J. Justin McCormick

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  1. Veronica M. Maher
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  2. J. Justin McCormick
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Editors and Affiliations

  1. National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA

    Frederick J. de Serres

  2. Associated Universities, Inc., Washington, D. C., USA

    Alexander Hollaender

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© 1980 Plenum Press, New York

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Maher, V.M., Justin McCormick, J. (1980). Comparison of the Mutagenic Effect of Ultraviolet Radiation and Chemicals in Normal and DNA-Repair-Deficient Human Cells in Culture. In: de Serres, F.J., Hollaender, A. (eds) Chemical Mutagens. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3072-1_11

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  • DOI: https://doi.org/10.1007/978-1-4613-3072-1_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3074-5

  • Online ISBN: 978-1-4613-3072-1

  • eBook Packages: Springer Book Archive

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