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The Role of S-Adenosylhomocysteine and S-Adenosylhomocysteine Hydrolase in the Control of Biological Methylations

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Natural Sulfur Compounds

Abstract

S-Adenosylhomocysteine (AdoHcy) (Fig. 1) was first identified as one of the products of the reactions that utilize S-adenosylmethionine (AdoMet) as a methyl donor by Scarano and Cantoni1 in 1954. Over the last 25 years, and especially in the last three or four years, AdoHcy has attracted increasing attention because it has become well established that AdoHcy is a competitive inhibitor of many, if not most, of the reactions in which AdoMet participates 2–13.

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Author information

Authors and Affiliations

  1. Laboratory of General and Comparative Biochemistry, National Institute of Mental Health, Bethesda, Maryland, 20205, USA

    Giulio L. Cantoni & Peter K. Chiang

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  1. Giulio L. Cantoni
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  2. Peter K. Chiang
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Editors and Affiliations

  1. University of Rome, Rome, Italy

    Doriano Cavallini

  2. Institute for Basic Research in Mental Retardation, Staten Island, New York, USA

    Gerald E. Gaull

  3. University of Naples, Naples, Italy

    Vincenzo Zappia

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© 1980 Plenum Press, New York

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Cantoni, G.L., Chiang, P.K. (1980). The Role of S-Adenosylhomocysteine and S-Adenosylhomocysteine Hydrolase in the Control of Biological Methylations. In: Cavallini, D., Gaull, G.E., Zappia, V. (eds) Natural Sulfur Compounds. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3045-5_6

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  • DOI: https://doi.org/10.1007/978-1-4613-3045-5_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3047-9

  • Online ISBN: 978-1-4613-3045-5

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