On the Mechanism of C-S Bonds Formation in the Biosynthesis of Biotin
The biosynthesis of biotin, 1, has already been intensively studied (1). All the intermediates in the biosynthetic pathway from pimelic acid to dethiobiotin, 2, are presently known and formed by classical biochemical reactions. But the mechanism of the conversion of dethiobiotin into biotin, a very unusual transformation, is still completely unknown.
KeywordsPermeability Aldehyde Carbonyl Biotin Alco
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