Abstract
Afferent unmyelinated (C) fibers are numerous in our peripheral cutaneous nerves, and they convey important messages about noxious skin stimuli and temperature changes in the skin. It is now possible to study in detail the discharge pattern of individual C units in human cutaneous nerves in situ (Torebjork and Hallin, 1970) and to correlate directly the afferent discharge in different types of C units with sensation (e.g. Hallin and Torebjörk, 1970; van Hees and Gybels, 1972; Torebjörk, 1974; Konietzny and Hensel, 1975). This report will summarize briefly the physiological properties of C nociceptors in normal and injured skin in man, with reference to sensations evoked by various impulse patterns in these nociceptors.
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References
Beck, P. W., Handwerker, H. O., & Zimmermann,M. Nervous outflow from the catTs foot during noxious heat stimulation. Brain Research, 1974, 67, 373–386.
Beitel, R. E. & Dubner, R. Response of unmyelinated (C) polymodal nociceptors to thermal stimuli applied to monkey’s face. Journal of Neurophysiology, 1976, 39, 1160–1175.
Bessou, P. & Perl, E. R. Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli. Journal of Neurophysiology, 1969, 32, 1025–1043.
Croze, S., Duclaux, R., & Kenshalo, D. R. The thermal sensitivity of the polymodal nociceptors in the monkey. Journal of Physiology (London), 1976, 263, 539–562.
Fitzgerald, M. & Lynn, B. The sensitization of high threshold mechanoreceptors with myelinated axons by repeated heating. Journal of Physiology (London), 1977, 365, 549–563.
Gasser, H. S. Properties of dorsal root unmedullated fibers on the two sides of the ganglion. Journal of General Physiology, 1955, 38, 709–728.
Hallin, R. G. & Torebjörk, H. E. Afferent and efferent C units recorded from human skin nerves in situ. Acta Societatis Medicorum Upsaliensis, 1970, 75, 277–281.
Hallin, R. G. & Torebjörk, H. E. Methods to differentiate electrically induced afferent and sympathetic C unit responses in human cutaneous nerves. Acta Physiologica Scandinavica, 1974, 92, 318–331.
Hallin, R. G\ & Torebjörk, H. E. Studies on cutaneous A and C fiber afferents, skin nerve blocks and perception. In Y. Zotterman (Ed.), Sensory functions of the skin in primates. Oxford: Pergamon Press, 1976.
Hees, van, J. Human C fiber input during painful and nonpainful skin stimulation with radiant heat. In J. J. Bonica & D. Albe-Fessard (Eds.), Advances in pain research and therapy. (Vol. 1 ), New York: Raven Press, 1976.
Hees, van, J. & Gybels, J. M. Pain related to single afferent C fibers from human skin. Brain Research, 1972, 48, 397–400.
Konietzny, F. & Hensel, H. Warm fiber activity in human skin nerves. Pflügers Archiv, 1975, 359, 265–267.
Kumazawa, T. & Perl, E. R. Primate cutaneous sensory units with unmyelinated (C) afferent fibers. Journal of Neurophysiology, 1977, 40, 1325–1338.
Mackenzie, R. A., Burke, D., Skuse, N. F., & Lethlean, A. K. Fiber function and perception during cutaneous nerve block. Journal of Neurology, Neurosurgery, and Psychiatry, 1975, 38, 865–873.
Meyer, R. A., Campbell, J. N., & LaMotte, R. H. Sensitization of A-delta nociceptive afferents to noxious radiant heat delivered to the monkey hand. Neuroscience Abstracts 7th Annual Meeting, 1973, 3, 487.
Ochoa, J. The unmyelinated nerve fiber. In D. N. Landon (Ed.), The peripheral nerve. London: Chapman and Hall, 1976.
Strughold, H. Uber die Dichte and Schwellen der Schmertzpunkte der Epidermis in den verschiedenen Körperregionen. Zeitschrift für Biologie, 1924, 80, 367–380.
Torebjörk, H. E. Afferent C units responding to mechanical, thermal and chemical stimuli in human non-glabrous skin. Acta Physiologica Scandinavica, 1974, 92, 374–390.
Torebjörk, H. E. & Hallin, R. G. C-fiber units recorded from human sensory nerve fascicles in situ. Acta Societatis Medicorum Upsaliensis, 1970, 75, 81–84.
Torebjörk, H. E. and Hallin, R. G. Perceptual changes accompanying controlled preferential blocking of A and C fiber responses in intact human skin nerves. Experimental Brain Research, 1973, 16, 321–332.
Torebjörk, H. E. & Hallin, R. G. Identification of afferent C units in intact human skin nerves. Brain Research, 1974a, 67, 387–403.
Torebjörk, H. E. & Hallin, R. G. Responses in human A and C fibers to repeated electrical intradermal stimulation. Journal of Neurology, Neurosurgery, and Psychiatry, 1974b, 37, 653–664.
Torebjörk, H. E. and Hallin, R. G. A new method for classification of C-unit activity in intact human skin nerves. In J. J. Bonica & D. Albe-Fessard (Eds.), Advances in pain research and therapy (Vol. 1 ), New York: Raven Press, 1976a.
Torebjörk, H. E. & Hallin, R. G. Skin receptors supplied by unmyelinated (C) fibers in man. In Y. Zotterman (Ed.), Sensory functions of the skin in primates. Oxford: Pergamon Press, 1976b.
Torebjörk, H. E. & Hallin, R. G. Sensitization of polymodal nociceptors with C fibers in man. Proceedings of the International Union of Physiological Sciences, 1977, 13, 758.
Torebjörk, H. E. & Hallin, R. G. Recordings of impulses in unmye-linated nerve fibers in man; afferent C fiber activity. Acta Anaesthesiologica Scandinavica, 1978, 70, 124–129.
Witt, J. & Griffin, J. P. Afferent cutaneous C-fiber reactivity to repeated thermal stimuli. Nature, 1962, 194, 776–777.
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Torebjörk, H.E. (1979). Activity in C Nociceptors and Sensation. In: Kenshalo, D.R. (eds) Sensory Functions of the Skin of Humans. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3039-4_17
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DOI: https://doi.org/10.1007/978-1-4613-3039-4_17
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