Monocyte Function in Bladder Cancer
A rosette assay was used to test Fc receptor expression of normal human monocytes cultured in a variety of media. Monocyte activity was suppressed by a heat stable ultrafiltrate of normal serum and of supernatants from cultured explants of malignant tumours, mainly superficial transitional cell carcinoma of the bladder removed by transurethral resection. The data supports an hypothesis that tumours develop by suppressing host macrophages at a particular site. This is achieved by subverting the normal physiological humoral control of monocyte activity in peripheral blood.
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