Abstract
Recent experimental studies have shown that the occurrence of bladder cancer is preceded by preneoplastic urothelial lesions, whose development is related to a series of well defined cell-surface changes at scanning electrone microscopy (SEM). Some lesions, as demonstrated by Jacobs et al (3) can regress upon removal of carcinogenic stimulus, while others appear to be irreversible, even if the carcinogen is discontinued. The appearance of pleomorphic microvilli on surface cells seems to represent the hallmark of irreversible hyperplasia in rats.
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References
Hodges, G. M., Hicks, R. M., Spacey, G. D., Scanning electron microscopy of cell-surface changes in methylnitrosurea (MNU) treated rat bladders in vivo and in vitro. Differentiation, 6, 143 (1976).
Newman, J., Hicks, R. M., Detection of neoplastic and preneoplastic urothelia by combined scanning and transmission electron microscopy of urinary surface of human and rat bladders. Histopathology, 1, 125 (1977).
Jacobs, J. B., Arai, M., Cohen, S., Friedell, G. H., A long term study of reversible and progressive urinary bladder cancer lesions in rats fed N-4-(5-nitro-2-furyl)-2-thiazolyl formamide. Cancer Res., 37, 2817 (1977).
Jacobs, J. B., Cohen, S. M., Arai, A., Friedell, G. H., SEM on bladder cancer cells. Acta Cytol., 21, 3 (1977).
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© 1980 Plenum Press, New York
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Casanova, S., Corrado, F. (1980). Scanning and Transmission Electron Microscopy of Hyperplastic and Neoplastic Human Urothelium. In: Pavone-Macaluso, M., Smith, P.H., Edsmyr, F. (eds) Bladder Tumors and other Topics in Urological Oncology. Ettore Majorana International Science Series, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3030-1_14
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DOI: https://doi.org/10.1007/978-1-4613-3030-1_14
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-3032-5
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