Abstract
During the study of the metabolism of the new oral drug THIOPROPAMINE ® (REDDEN), prepared in Alfa Farmaceutici Laboratories, we identified, among others, a metabolite in rat and human urines, whose acetyl derivative exhibited intense interrelated ions at m/e 113, 72, 70, the origin of which appeared to be linked to the presence of the amide function, since the corresponding amine gave three related peaks respectively at m/e 71, 30 and 70 (Figs. 1 and 2).
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© 1979 Plenum Press, New York
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Borzatta, V., Cristofori, M., Giumanini, A.G. (1979). The Electron Impact Fragmentation of Products Related to N-(Allyl)-3,3-Diphenylpropylamine, a Metabolite from Thiopropamine ®. In: Frigerio, A. (eds) Recent Developments in Mass Spectrometry in Biochemistry and Medicine. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3018-9_8
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DOI: https://doi.org/10.1007/978-1-4613-3018-9_8
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-3020-2
Online ISBN: 978-1-4613-3018-9
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