Metabolic Profile of Ventricular Cerebrospinal Fluids

Abstract

The complexity of biochemical reaction in the central nervous system is easily suspected from the fact that the central nervous system in the human and also in animals plays a very important role in integration of the whole function of the individual. Biochemical reaction in the central nervous system has a specificity because this system is separated and protected by the blood-brain-barrier from other organs. Various scientific approaches have been performed to clarify mechanism of the central nervous system underlying delicate and nearly mysterious integrative function, but so far this mechanism seems to reject any sophisticated scientific approach (1–3). The investigation of biochemical reaction in the central nervous system has contributed much to the understanding of the mechanism related to neuropsychiatric disease and also its diagnoses and treatment. For the investigation of metabolism of the central nervous system in its broad sense we have analyzed organic acid and amino acid in cerebrospinal fluids utilizing gas chromatography and mass spectrometry. The cerebrospinal fluid was obtained from the intraventricular and lumber subarachinoid space of patients who are suffering from various kinds of neurological disorders. The result will be briefly reported.