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Gas Chromatographic-Mass Spectrometric Identification of Urinary Metabolites of Propildazine in Rat

  • L. Simonotti
  • R. Colombo
  • G. Pifferi

Abstract

Propildazine (ISF 2123) is a new antihypertensive drug selected among a series of 6-substituted 3-hydrazinopyridazines synthesized in our laboratories (1–3) (Fig. 1).

Keywords

Urinary Metabolite Amino Alcohol Derivative Versus Charge Retention Silyl Derivative 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1).
    G. Pifferi, F. Parravicini, C. Carpi and L. Dorigotti, J. Med. Chem., 1976, 18, 741.CrossRefGoogle Scholar
  2. 2).
    F. Parravicini, G. Scarpitta, L. Dorigotti and G. Pifferi, Farmaco, ed. Sci., 1978, 33, 99.Google Scholar
  3. 3).
    Drugs of the Future, 1976, l, 290.Google Scholar
  4. 4).
    L. Dorigotti, R. Rolandi and C. Carpi, Pharmacol. Res. Commuti., 1976, 8, 295.Google Scholar
  5. 5).
    L. Dorigotti, C. Semeraro and C. Carpi, Riassunti 7° Congresso S.S.F.A., Varese, 11-12 ottobre 1977.Google Scholar
  6. 6).
    R. Pellegrini and G. Abbondati, Farmaco, ed. Sci., 1977, 32, 19Google Scholar
  7. 7).
    L. Simonotti et al., to be published.Google Scholar
  8. 8).
    F. Parravicini, G. Scarpitta, L. Dorigotti and G. Pifferi, Farmaco, ed. Sci., in press.Google Scholar
  9. 9).
    H. Budzikiewicz, C. Djerassi and D.H. Williams, in “Mass Spectrometry of Organic Compounds”, Holden Day Inc., 1967, p. 297.Google Scholar
  10. 10).
    L. Simonotti et al., to be published.Google Scholar
  11. 11).
    K.D. Haegele, H.B. Skrdlant, N.W. Robie, D. Lalka and J.L. McNay Jr., J. Chromatogr., 1976, 126, 517.CrossRefGoogle Scholar
  12. 12).
    R. Moroi, K. Ono, T. Saito, T. Akimoto and M. Sano, Chem. Pharm Bull., 1977, 25, 830.Google Scholar
  13. 13).
    A.E. Pierce, in “Silylation of Organic Compounds”, Pierce Chemical Company, Rockford, 111., 1968, p. 63.Google Scholar
  14. 14).
    V. Pire, B. Stanovnik, T. Tisler, J. Marsel and W.W. Paudler, J. Het. Chem., 1970, 7 639.CrossRefGoogle Scholar
  15. 15).
    H. Zimmer, R. Glaser, J. Kokosa, D. Garteiz, E.V. Hess and A. Litwin, J. Med. Chem., 1975, 18, 1031.CrossRefGoogle Scholar
  16. 16).
    Z.H. Israili and P.G. Dayton, Drug Metab. Rev., 1977, 6, 283.CrossRefGoogle Scholar
  17. 17).
    Life Science Research, internal report, 1976.Google Scholar
  18. 18).
    G. Pifferi, F. Parravicini, G. Scarpitta and C. Semeraro, VIth Int. Symposium on Medicinal Chemistry, Brighton, 4–7 Sept., 1978.Google Scholar

Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • L. Simonotti
    • 1
  • R. Colombo
    • 1
  • G. Pifferi
    • 1
  1. 1.I.S.F. - Italseber Research LaboratoriesTrezzano s/N, MilanoItaly

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