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Gas Chromatographic-Mass Spectrometric Identification of Urinary Metabolites of Propildazine in Rat

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Recent Developments in Mass Spectrometry in Biochemistry and Medicine

Abstract

Propildazine (ISF 2123) is a new antihypertensive drug selected among a series of 6-substituted 3-hydrazinopyridazines synthesized in our laboratories (1–3) (Fig. 1).

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References

  1. G. Pifferi, F. Parravicini, C. Carpi and L. Dorigotti, J. Med. Chem., 1976, 18, 741.

    Article  Google Scholar 

  2. F. Parravicini, G. Scarpitta, L. Dorigotti and G. Pifferi, Farmaco, ed. Sci., 1978, 33, 99.

    Google Scholar 

  3. Drugs of the Future, 1976, l, 290.

    Google Scholar 

  4. L. Dorigotti, R. Rolandi and C. Carpi, Pharmacol. Res. Commuti., 1976, 8, 295.

    Google Scholar 

  5. L. Dorigotti, C. Semeraro and C. Carpi, Riassunti 7° Congresso S.S.F.A., Varese, 11-12 ottobre 1977.

    Google Scholar 

  6. R. Pellegrini and G. Abbondati, Farmaco, ed. Sci., 1977, 32, 19

    Google Scholar 

  7. L. Simonotti et al., to be published.

    Google Scholar 

  8. F. Parravicini, G. Scarpitta, L. Dorigotti and G. Pifferi, Farmaco, ed. Sci., in press.

    Google Scholar 

  9. H. Budzikiewicz, C. Djerassi and D.H. Williams, in “Mass Spectrometry of Organic Compounds”, Holden Day Inc., 1967, p. 297.

    Google Scholar 

  10. L. Simonotti et al., to be published.

    Google Scholar 

  11. K.D. Haegele, H.B. Skrdlant, N.W. Robie, D. Lalka and J.L. McNay Jr., J. Chromatogr., 1976, 126, 517.

    Article  Google Scholar 

  12. R. Moroi, K. Ono, T. Saito, T. Akimoto and M. Sano, Chem. Pharm Bull., 1977, 25, 830.

    Google Scholar 

  13. A.E. Pierce, in “Silylation of Organic Compounds”, Pierce Chemical Company, Rockford, 111., 1968, p. 63.

    Google Scholar 

  14. V. Pire, B. Stanovnik, T. Tisler, J. Marsel and W.W. Paudler, J. Het. Chem., 1970, 7 639.

    Article  Google Scholar 

  15. H. Zimmer, R. Glaser, J. Kokosa, D. Garteiz, E.V. Hess and A. Litwin, J. Med. Chem., 1975, 18, 1031.

    Article  Google Scholar 

  16. Z.H. Israili and P.G. Dayton, Drug Metab. Rev., 1977, 6, 283.

    Article  Google Scholar 

  17. Life Science Research, internal report, 1976.

    Google Scholar 

  18. G. Pifferi, F. Parravicini, G. Scarpitta and C. Semeraro, VIth Int. Symposium on Medicinal Chemistry, Brighton, 4–7 Sept., 1978.

    Google Scholar 

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© 1979 Plenum Press, New York

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Simonotti, L., Colombo, R., Pifferi, G. (1979). Gas Chromatographic-Mass Spectrometric Identification of Urinary Metabolites of Propildazine in Rat. In: Frigerio, A. (eds) Recent Developments in Mass Spectrometry in Biochemistry and Medicine. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3018-9_3

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  • DOI: https://doi.org/10.1007/978-1-4613-3018-9_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3020-2

  • Online ISBN: 978-1-4613-3018-9

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