Abstract
We have previously described a method (1) employing liquid-gel chromatography on Sephadex LH-20, gas chromatography and gas chromatography-mass spectrometry for the analysis of the principal C18, C19 C21 steroids excreted during a normal pregnancy. This paper describes the application of such a method, to the study of the alteration in steroid production and metabolism which occur during a pathological pregnancy. The mother, who had a history of adrenal hyperplasia due to 21-hydroxylase deficiency, was delivered of a normal female infant at term. The steroids excreted during the first, second and third trimester of pregnancy were analysed, identified and quantitated.
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© 1979 Plenum Press, New York
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Losty, H., Begue, R.J., Moriniere, M., Padieu, P. (1979). Analysis of the Urinary Steroids from a Pathological Pregnancy by Liquid-Gel Chromatography and Gas-Chromatography-Mass Spectrometry. In: Frigerio, A. (eds) Recent Developments in Mass Spectrometry in Biochemistry and Medicine. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3018-9_22
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DOI: https://doi.org/10.1007/978-1-4613-3018-9_22
Publisher Name: Springer, Boston, MA
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