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The Determination of Blood Cyanide and Plasma Thiocyanate by Gas Chromatography-Mass Spectrometry

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Recent Developments in Mass Spectrometry in Biochemistry and Medicine

Abstract

Cyanide is a normal constituent of blood, present at very low levels, usually less than 20 µmoles/1 blood (1, 2). It is involved in a number of metabolic reactions of which the conversion to thiocyanate is quantitatively the most important (3). Thiocyanate may therefore be used as an index of transformed cyanide (4). Methods for the analysis of these two species in body fluids are necessarily extremely sensitive and the existing techniques include colourimetry (4, 5), fluorimetry (6, 7) and gas chromatography (8–10).

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© 1979 Plenum Press, New York

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Thomson, I., Anderson, R.A., Harland, W.A. (1979). The Determination of Blood Cyanide and Plasma Thiocyanate by Gas Chromatography-Mass Spectrometry. In: Frigerio, A. (eds) Recent Developments in Mass Spectrometry in Biochemistry and Medicine. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3018-9_18

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  • DOI: https://doi.org/10.1007/978-1-4613-3018-9_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3020-2

  • Online ISBN: 978-1-4613-3018-9

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