Abstract
Among aromatic amines, fluorenyl amines are the most potent carcinogens which in addition exhibit a multi-tissular target effect. The development of fluorene chemistry 40–50 years ago led to the synthesis of 2-acetylaminofluorene (2-AAF) as a very efficient insecticide, the toxicity of which has been tested by Wilson et al. (1). Despite the lack of early toxic effects in the rat fed with 0.02% 2-AAF added to the diet, these authors pursued the appraisal and observed, after three months, the appearance of primitive cancerous tumors at various locations: liver, mammary gland, earduct and its sebaceous Zymbal gland, intestine, lung, kidney, bladder, salivary gland, adrenal, etc… Such substituted fluorenylamines also induce neoplastic growth in tobacco cell culture (2).
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© 1979 Plenum Press, New York
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Lallemant, C. et al. (1979). GC-MS Analysis by Electron Impact Ionization and Chemical Ionization of Carcinogenic 2-Acetylaminofluorene and its Metabolites. In: Frigerio, A. (eds) Recent Developments in Mass Spectrometry in Biochemistry and Medicine. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3018-9_14
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DOI: https://doi.org/10.1007/978-1-4613-3018-9_14
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