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Molecular Replacement Method

  • Chapter
Theory and Practice of Direct Methods in Crystallography

Abstract

The term molecular replacement encompasses a variety of techniques designed to utilize the occurrence of a molecule, molecular subunit, or molecular fragment in more than one crystallographic environment for the purpose of phase refinement. The limited size of nature’s building blocks and the necessity of their aggregation into molecules with closed point symmetries (Crick and Watson, 1956; Monod et al., 1965) provide the basis of the subject and its application to macromolecules. For example, a particular compound may be induced to crystallize in different forms, or a given molecule might be composed of several identical subunits.

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Authors and Affiliations

  1. Department of Biological Sciences, Purdue University, West Lafayette, Indiana, USA

    Patrick Argos & Michael G. Rossman

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  1. Patrick Argos
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  1. University of Surrey, Guildford, Surrey, England

    M. F. C. Ladd

  2. Birkbeck College, University of London, London, England

    R. A. Palmer

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Argos, P., Rossman, M.G. (1980). Molecular Replacement Method. In: Ladd, M.F.C., Palmer, R.A. (eds) Theory and Practice of Direct Methods in Crystallography. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2979-4_10

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