Brain Cholinergic Enzymes in Schizophrenia

  • E. F. Domino


It is a fact that acetylcholine (ACh) is involved in many aspects of animal and human behavior (Karczmar and Dun, 1978). It is natural that the cholinergic system be investigated for possible abnormalities in mental disease including the schizophrenias. The enzymes of obvious interest are those which synthesize and hydrolyze ACh. In addition, the levels of the two substrates acetylcoenzyme A and choline are of great importance, as well as the turnover of both substrates and their product ACh. In human autopsy material the cholinergic brain enzymes and receptors are the only substances that can be measured reliably. Hence, this review will concentrate on these enzymes in schizophrenia.


Schizophrenic Patient AChE Activity Senile Dementia Cholinesterase Activity Septal Area 
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Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • E. F. Domino
    • 1
    • 2
  1. 1.Department of PharmacologyUniversity of MichiganAnn ArborUSA
  2. 2.Laboratory of PharmacologyLafayette ClinicDetroitUSA

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