Abstract
Acetylcholinesterase (AChE) has been identified in cerebrospinal fluid (CSF) (Kalsbeek et al., 1950; Svensmark, 1961; Johnson and Domino, 1971; Yaksh et al., 1974). The majority of CSF AChE has been shown to derive from the brain with little if any contribution from the plasma (Yaksh et al., 1975). The possibility of a large contribution to CSF AChE from the spinal cord is unlikely as histochemical studies of spinal tracts have failed to demonstrate appreciable staining for AChE (Koelle, 1963). The caudate nucleus contains the highest concentrations of AChE (Yaksh et al., 1975). Its proximity to the lateral ventricles suggests that this structure makes a sizeable contribution to total CSF AChE.
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Davis, K.L., Livesey, J., Hollister, L.E., Berger, P.A. (1979). Cerebrospinal Fluid Acetylcholinesterase in Psychosis and Movement Disorders. In: Davis, K.L., Berger, P.A. (eds) Brain Acetylcholine and Neuropsychiatric Disease. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2934-3_5
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DOI: https://doi.org/10.1007/978-1-4613-2934-3_5
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