Skip to main content
SpringerLink
Log in

Acetylcholine and Anterior Pituitary Hormone Secretion

  • Chapter
Brain Acetylcholine and Neuropsychiatric Disease

Abstract

This chapter deals with the effects of acetylcholine (ACh) on anterior pituitary hormone secretion. The literature is reviewed. In general, previous investigations of the effects of cholinergic stimuli indicate stimulation of the hypothalamo-hypophyseal-adrenal and gonadal axes. Cholinergic stimulation seems to inhibit prolaction secretion. Little information is available on growth hormone.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Balfour, D.J.K., Khyllar, A.K., and Longden, A., 1975, Effects of nicotine on plasma corticosterone and brain amines in stressed and unstressed rats, Pharmacol Biochem. Behav. 3: 179.

    Article  PubMed  CAS  Google Scholar 

  • Blake, C.A., 1974, Parallelism and divergence in luteinizing hormone andfollicle-stimulating hormone release in nicotine-treated rats (31881), Proc. Soc. Exp. Biol Med. 145: 716.

    PubMed  CAS  Google Scholar 

  • Blake, C.A., and Sawyer, C.H., 1972, Nicotine blocks the suckling-induced rise in circulating prolactin in lactating rats, Science 177: 619.

    Article  PubMed  CAS  Google Scholar 

  • Blake, C.A., Scaramuzzi, R.J., Norman, R.L., Kanematsu, S., and Sawyer, C.H., 1972, Nicotine delays the ovulatory surge of luteinizing hormone in the rat (36922), Proc. Soc. Exp. Biol Med. 141: 1014.

    PubMed  CAS  Google Scholar 

  • Blake, C.A., Norman, R.L., Scaramuzzi, R.J., and Sawyer, C.H., 1973, Inhibition of the proestrous surge of prolactin in the rat by nicotine, Endocrinology 92(5): 1334.

    Google Scholar 

  • Blake, C.A., Norman, R.L., and Sawyer, C.H., 1974, Localization of the inhibitory actions of estrogen and nicotine on release of luteinizing hormone in rats, Neuroenddcrinology 16: 22.

    Article  CAS  Google Scholar 

  • Bradbury, M.W.B., Burden, J., Hillhouse, E.W., and Jones, M.T., 1974, Stimulation electrically and by acetylcholine of the rat hypothalamus in vitro, J. Physiol (Lond) 239: 269.

    CAS  Google Scholar 

  • Burnett, G.R., Prange, A.J., Wilson, E.C., and Snyder, S.H., 1978, Neuroendocrine-drug relations in tardive dyskinesia. Abstract NR21 for the Annual Meeting of the American Psychiatric Association, Atlanta, Georgia.

    Google Scholar 

  • Carroll, B.J., Curtis, G.C., and Mendels, I., 1976, Neuroendocrine regulation in depression. II. Discrimination in depressed from nondepressed patients, Arch. Gen. Psychiatry 33(9): 1051.

    PubMed  CAS  Google Scholar 

  • Cozanitis, D.A., 1974, Galanthamine hydrobromide versus neostigmine, Anesthesia 29: 163.

    Article  CAS  Google Scholar 

  • Davis, K.L., Hollister, L.E., Berger, P.A., and Barchas, J.D., 1975, Cholinergic imbalance hypotheses of psychoses and movement disorders: Strategies for evaluation, Psycho- pharmacol. Comm. 1(5): 533.

    Google Scholar 

  • Davis, K.L., Berger, P.A., Hollister, L.E., and De Fraites, E.G., 1978, Physostigmine in mania, Arch. Gen. Psychiatry 35(1): 119.

    Google Scholar 

  • Donoso, A.O., and Bacha, J.C., 1975a, Role of the blood-brain barrier in the anticholinergic differential effects on LH and prolactin release in proestrous rats, J. Neural Transm. 37: 155.

    Article  PubMed  CAS  Google Scholar 

  • Donoso, A.O., and Bacha, J.C., 1975b, Acetylcholine induced responses of plasma LH and prolactin in normal and 6-hydroxydopamine treated rats, J. Neural Transm. 37: 269.

    Article  PubMed  CAS  Google Scholar 

  • Edwardson, J.A., and Bennett, G.W., 1974, Modulation of corticotrophin-releasing factor release from hypothalamic synaptosomes, Nature 251: 425.

    Article  PubMed  CAS  Google Scholar 

  • Endroczi, E., Schreiberg, G., and Lissak, K., 1963, The role of central nervous activating and inhibitory structures in the control of pituitary-adrenocortical function. Effects of intracerebral cholinergic and adrenergic stimulation, Acta Physiol Acad. Hung. 24: 211.

    Google Scholar 

  • Ferrari, E., Bossolo, P.A., Vailati, A., Martinelli, I., Rea, A., and Nosari, I., 1977, Variations circadiennes des effets d’une substance vagolytique sur le systeme ACTH-secretant chez l’homme, Ann. Endocrinol (Paris) 38: 203.

    CAS  Google Scholar 

  • Fiorindo, R.P., and Martini, L., 1975, Evidence for a cholinergic component in the neuroendocrine control of luteinizing hormone (LH) secretion, Neuroendocrinology 18: 322.

    Article  CAS  Google Scholar 

  • Grandison, L., and Meites, J., 1976a, Evidence for adrenergic mediation of cholinergic inhibition of prolactin release, Endocrinology 99(3): 775.

    Google Scholar 

  • Grandison, L., and Meites, J., 1976b, Inhibition of pseudopregnancy and stress induced by prolactin release in rats by pilocarpine, Fed. Proc. 35: 306.

    Google Scholar 

  • Grandison, L., Gelato, M., and Meites, J., 1974, Inhibition of prolactin secretion by cholinergic drugs (37988), Proc. Soc. Biol Med. 145: 1236.

    CAS  Google Scholar 

  • Harwood, C.T., and Mason, I.W., 1956, Effects of intravenous infusion of autonomic agents in peripheral blood 17-hydroxycorticosteroid levels in the dog, Am. J. Physiol. 186: 445.

    PubMed  CAS  Google Scholar 

  • Hedge, G.A., and de Wied, D., 1971, Corticotropin and vasopressin secretion after hypothalamic implantation of atropine, Endocrinology 88: 1257.

    Article  PubMed  CAS  Google Scholar 

  • Hedge, G.A., and Smelik, P.G., 1968, Corticotropin release: Inhibition by intrahypothalamic implantation of atropine, Science 159: 891.

    Article  PubMed  CAS  Google Scholar 

  • Hill, P., and Wynder, E.L., 1974, Smoking and cardiovascular disease, Am. Heart J. 87(4): 491.

    Google Scholar 

  • Hillhouse, E.W., Burden, J., and Jones, M.T., 1975, The effect of various putative neurotransmitters on the release of corticotrophin releasing hormone from the hypothalamus of the rat in vitro. I. The effect of acetylcholine and noradrenaline, Neuroendocrinology 17: 1.

    Article  PubMed  CAS  Google Scholar 

  • Innes, I.R., and Nickerson, M., 1970, Drugs inhibiting the action of acetylcholine on structures innervated by postganglionic parasympathetic nerves (antimuscarinic or atropinic drugs), in “The Pharmacological Basis of Therapeutics” (L.S. Goodman and A. Gilman, eds.), pp. 528–548, MacMillan Company, New York.

    Google Scholar 

  • Janowsky, D.S., El-Yousef, M.K., Davis, J.M., and Sekerke, H.J., 1972, A cholinergic adrenergic hypothesis of mania and depression, Lancet 2: 632.

    Article  PubMed  CAS  Google Scholar 

  • Janowsky, D.S., El-Yousef, J.K., and Davis, J.M., 1973, Parasympathetic suppression of manic symptoms by physostigmine, Arch. Gen. Psychiatry 28: 542.

    PubMed  CAS  Google Scholar 

  • Justo, G., Motta, M., and Martin, L., 1975, In vivo effects of acetylcholine on LH secretion, Experientia 31(5):598.

    Google Scholar 

  • Kanematsu, S., and Sawyer, C.H., 1973, Inhibition of the progesterone-advanced LH surge at proestrus by nicotine (37497), Proc. Soc. Exp. Biol. Med. 143: 1183.

    PubMed  CAS  Google Scholar 

  • Kaplanski, J., and Smelik, P.G., 1973, Analysis of the inhibition of the ACTH release by hypothalamic implants of atropine, Acta Endocrinol (Kbh) 73: 651.

    CAS  Google Scholar 

  • Kato, Y., Chihara, K., Ohgo, S., and Imura, H., 1974, Effect of nicotine on the secretion of growth hormone and prolactin in rats, Neuroendocrinology 16: 231.

    Article  Google Scholar 

  • Krieger, D.T., and Krieger, H.P., 1967, Circadian pattern of plasma 17-hydroxy corticosteroid. Alteration by anticholinergic agents, Science 755: 1421.

    Article  Google Scholar 

  • Krieger, HJP., and Krieger, D.T., 1970, Chemical stimulation of the brain: Effect on adrenal corticoid release, Am. J. Physiol. 218: 1632.

    PubMed  CAS  Google Scholar 

  • Krieger, D.T., Silverberg, A.I., Rizzo, F., and Krieger, H.P., 1968, Abolition of circadian periodicity of plasma 17-OHCS levels in the cat, Am. J. Physiol. 215(4): 959.

    Google Scholar 

  • Lawson, D.M., and Gala, R.R., 1975, The influence of adrenergic, dopaminergic, cholinergic and serotoninergic drugs on plasma prolactin levels in ovariectomized, estrogentreated rats, Endocrinology 96(1): 313.

    Google Scholar 

  • Libertun, C., and McCann, S.M., 1973, Blockade of the release of gonadotropins and prolactin by subcutaneous or intraventricular injection of atropine in male and female rats, Endocrinology 92(6): 1714.

    Google Scholar 

  • Libertun, C., and McCann, S.M., 1974, Further evidence for cholinergic control of gonadotropin and prolactin secretion (38374), Proc. Soc. Exp. Biol. Med. 147: 498.

    PubMed  CAS  Google Scholar 

  • Libertun, C., and McCann, S.M., 1976, Blockade of the postorchidectomy increase gonadotropins by implants of atropine into the hypothalamus (39347), Proc. Soc. Exp. Biol. Med. 152: 143.

    PubMed  CAS  Google Scholar 

  • Makara, G.B., and Stark, E., 1976, The effects of cholinomimetic drugs and atropine on ACTH release, Neuroendocrinology 21: 31.

    Article  PubMed  CAS  Google Scholar 

  • McLean, B.K., and Nikitovitch-Winer, M.B., 1975, Cholinergic control of the nocturnal prolactin surge in the pseudopregnant rat, Endocrinology 97(4): 763.

    Google Scholar 

  • Monti, J.M., Sala, M.A., Otegui, J.T., and Benedeth, W.L., 1970, Inhibition of ovarian compensatory hypertrophy by implants of atropine in the hypothalamus, Experientia 26(11): 1263.

    Google Scholar 

  • Naumenko, E.V., 1967, Role of adrenergic and cholinergic structures in the control of the pituitary-adrenal system. Endocrinology 80: 69.

    Article  PubMed  CAS  Google Scholar 

  • Naumenko, E.V., 1968, Hypothalamic chemoreactive structures and the regulation of pituitary-adrenal function. Effects of local injections of norepinephrine, carbachol and serotonin into the brain of guinea pigs with intact brains after mesencephalic transection, Brain Res. 11: 1.

    Article  PubMed  CAS  Google Scholar 

  • Otsuka, K., 1966, Effects of atropine, eserine and te trame thy lammonium on the adrenal 17-hydroxycorticosteroid secretion in anesthetized dogs, Tohoku J. Exp. Med. 88: 165.

    Article  PubMed  CAS  Google Scholar 

  • Porter, J.C., Goldman, B.D., and Wilber, J.F., 1970, Hypophysiotropic hormones in portal vessel blood, in “Hypophysio trophic Hormones of the Hypothalamus” ( J. Meites, ed.), pp. 282–293, Williams and Wilkins, Baltimore.

    Google Scholar 

  • Sawyer, C.H., Markee, J.E., and Everett, J.W., 1951, Blockade of neurogenic stimulation of the rabbit adenohypophysis by banthine, Am. J. Physiol. 166: 223.

    PubMed  CAS  Google Scholar 

  • Subramanian, M.G., and Gala, R.R., 1976, The influence of cholinergic, adrenergic, serotonergic drugs on the afternoon surge of plasma prolactin in ovariectomized, estrogen-treated rats, Endocrinology 98(4): 842.

    Google Scholar 

  • Suzuki, T., Hirai, K., Yoshio, H., Kurouji, K.I., and Hirose, T., 1964, Effect of eserine and atropine on adrenocortical hormone secretion in unanaesthetized dogs, Endocrinology 57: 81.

    Google Scholar 

  • Suzuki, T., Abe, K., and Hirose, T., 1975a, Adrenal cortical secretion in response to pilocarpine in dogs with hypothalamic lesions, Neuroendocrinology 17:15.

    Article  Google Scholar 

  • Suzuki, T., Hirose, T., Abe, K., and Matsumoto, I., 1975b, Dissociation of adrenocortical secretory responses to cyanide and pilocarpine in dogs with hypothalamic lesions, Neuroendocrinology 19: 269.

    Article  PubMed  CAS  Google Scholar 

  • Terkel, J., Blake, C.A., Hoover, V., and Sawyer, C.H., 1973, Pup survival and prolactin levels in nicotine-treated lactating rats (37485), Proc. Soc. Exp. Biol. Med. 143: 1131.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Psychiatry, Veterans Administration Hospital, 3801 Miranda Avenue, Palo Alto, California, 94304, USA

    B. M. Davis & K. L. Davis

Authors
  1. B. M. Davis
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K. L. Davis
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Veterans Administration Hospital, Palo Alto, California, 94304, USA

    Kenneth L. Davis  & Philip A. Berger  & 

  2. Stanford University School of Medicine, Stanford, California, 94305, USA

    Kenneth L. Davis  & Philip A. Berger  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1979 Plenum Press, New York

About this chapter

Cite this chapter

Davis, B.M., Davis, K.L. (1979). Acetylcholine and Anterior Pituitary Hormone Secretion. In: Davis, K.L., Berger, P.A. (eds) Brain Acetylcholine and Neuropsychiatric Disease. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2934-3_26

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-2934-3_26

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-2936-7

  • Online ISBN: 978-1-4613-2934-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation