Pharmacological Investigations of Cholinergic Mechanisms in Schizophrenia and Manic Psychosis

  • P. A. Berger
  • K. L. Davis
  • L. E. Hollister


During the past twenty years the biological investigation of major emotional disorders has focused on possible disturbances of central neurotransmission. The possible roles of serotonin, norepinephrine and dopamine have been reviewed recently (Schildkraut, 1974; Shopin et al., 1974; Goodwin and Murphy, 1974; Matthysse and Lipinski, 1975; Baldessarini, 1975; Berger, 1977; Berger et al., 1978). Other recent reviews have considered the possible role of alterations in the balance between neurotransmitters (Janowsky et al., 1972b; Friedhoff and Alpert, 1973; Davis et al., 1975). This chapter will focus on the possible role of cholinergic mechanisms in the pathophysiology of schizophrenia and the affective disorders.


Schizophrenic Patient Tardive Dyskinesia Brief Psychiatric Rate Scale Choline Chloride Corpus Striatum 
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Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • P. A. Berger
    • 1
    • 2
  • K. L. Davis
    • 1
    • 2
  • L. E. Hollister
    • 1
    • 2
  1. 1.Veterans Administration HospitalPalo AltoUSA
  2. 2.Department of Psychiatry and Behavioral SciencesStanford University School of MedicineStanfordUSA

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