Psychological Effects of Cholinomimetic Agents

  • D. S. Janowsky
  • J. M. Davis


Janowsky, Davis and colleagues began in 1972 to explore the possibility that the affective disorders, mania and depression, might be due to a complex balance, or inter-action, between adrenergic and cholinergic factors (Janowsky et al., 1972a). Proposed most simply, mania was hypothesized to be a syndrome due to relatively diminished central acetylcholine (ACh) activity, compared to normal or increased noradrenergic and/or dopaminergic activity; and depression was proposed to be the converse (Janowsky et al., 1972b).


Affective Disorder Manic Symptom Dopaminergic Activity Cholinergic Activity Antimanic Effect 
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Copyright information

© Plenum Press, New York 1979

Authors and Affiliations

  • D. S. Janowsky
    • 1
  • J. M. Davis
    • 1
  1. 1.Department of PsychiatryUniversity of California at San Diego, School of MedicineLa JollaUSA

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