Biosynthesis of Glycosaminoglycans

  • George W. Jourdian


The low levels of glycosaminoglycans present in nervous tissue have in the past deterred the study of their chemistry and metabolism in this tissue. Now, however, the use of radioisotopes, the recent development of sensitive, specific colorimetric and enzyme methodologies, and the development of procedures for the isolation of the various cell types and subcellular fractions unique to nervous tissue have prompted renewed interest as to the role of glycosaminoglycans in the development and function of this tissue in health and disease. This chapter reviews recent progress concerning the biosynthesis of glycosaminoglycans in nervous tissue.


Hyaluronic Acid Heparan Sulfate Chondroitin Sulfate Nervous Tissue Dermatan Sulfate 
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© Plenum Press, New York 1979

Authors and Affiliations

  • George W. Jourdian
    • 1
  1. 1.Rackham Arthritis Research Unit and Department of Biological ChemistryUniversity of MichiganAnn ArborUSA

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