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Complex Carbohydrates of Nervous Tissue pp 103–125Cite as

Biosynthesis of Glycosaminoglycans

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Abstract

The low levels of glycosaminoglycans present in nervous tissue have in the past deterred the study of their chemistry and metabolism in this tissue. Now, however, the use of radioisotopes, the recent development of sensitive, specific colorimetric and enzyme methodologies, and the development of procedures for the isolation of the various cell types and subcellular fractions unique to nervous tissue have prompted renewed interest as to the role of glycosaminoglycans in the development and function of this tissue in health and disease. This chapter reviews recent progress concerning the biosynthesis of glycosaminoglycans in nervous tissue.

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  1. Rackham Arthritis Research Unit and Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan, USA

    George W. Jourdian

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  1. New York University Medical Center, New York, New York, USA

    Richard U. Margolis

  2. Downstate Medical Center, State University of New York, Brooklyn, New York, USA

    Renée K. Margolis

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Jourdian, G.W. (1979). Biosynthesis of Glycosaminoglycans. In: Margolis, R.U., Margolis, R.K. (eds) Complex Carbohydrates of Nervous Tissue. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2925-1_5

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  • DOI: https://doi.org/10.1007/978-1-4613-2925-1_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-2927-5

  • Online ISBN: 978-1-4613-2925-1

  • eBook Packages: Springer Book Archive

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