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Role of Androgen Receptors in Stromal-Epithelial Interactions in Prostatic Cancer

  • Leland W. K. Chung
  • Timothy C. Thompson
  • Audrey K. Rocco
  • Abdulmaged M. Traish
  • Herbert H. Wotiz
Chapter
Part of the Cancer Treatment and Research book series (CTAR, volume 19)

Abstract

Since the demonstration in 1941 by Huggins and Hodges on the endocrine dependency of neoplastic human prostate [1], this relationship has formed the foundation for investigations into the mechanism(s) of steroid hormone action on hormone-responsive target tissues. The discovery of the high affinity and limited capacity of estrogen receptors in immature rat uterus by Jensen [2] has firmly established the initial steps of steroid hormone and target tissue interactions. The rigid structural requirements of steroid hormones, their specific binding to cytoplasmic receptor proteins to form receptor protein complexes, and their ability to elicit specific biological responses have been documented at molecular [3, 4], genetic [5, 6], and developmental [7, 8] levels. Similar receptor proteins for androgens [9, 10], estrogens [11, 12], and/or progestins [13] have been demonstrated to exist in the prostate gland of virtually all species studied.

Keywords

Androgen Receptor Sodium Molybdate Human Prostatic Tissue Exchange Assay Steroid Binding Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Martinus Nijhoff Publishers, Boston 1984

Authors and Affiliations

  • Leland W. K. Chung
  • Timothy C. Thompson
  • Audrey K. Rocco
  • Abdulmaged M. Traish
  • Herbert H. Wotiz

There are no affiliations available

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