Abstract
The clinical efficacy of Factor VIII therapeutic preparations has never been formally established since no controlled trial has ever been done comparing a preparation containing biological Factor VIII activity and a control. However, years of replacement therapy with whole blood, plasma, cyroprecipitate and concentrate have provided evidence for their efficacy. The clinical evaluation of these products is always difficult in hemophiliacs due to the rarity of open hemorrhages leaving the clinician with criteria such as pain, joint movements or joint circumferences to estimate efficacy.
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© 1984 Martinus Nijhoff Publishers, Boston
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Allain, JP. (1984). Clinical Efficacy and Safety of Factor VIII Concentrate. In: Sibinga, C.T.S., Das, P.C., Taswell, H.F. (eds) Quality Assurance in Blood Banking and Its Clinical Impact. Developments in Hematology and Immunology, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2835-3_19
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DOI: https://doi.org/10.1007/978-1-4613-2835-3_19
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