Skip to main content

Part of the book series: Developments in Hematology and Immunology ((DIHI,volume 7))

  • 81 Accesses

Abstract

The transfusion of blood and its components is a widely used form of supportive therapy and this field has expanded greatly in recent years due to the development of more intensive treatment modalities. This is particularly true for patients with malignant diseases, where the application of high dose cytotoxic therapy often results in periods of severe bone marrow depression. This has stimulated the development of a sophisticated platelet and granulocyte substitution therapy. However, we must bear in mind that a significant number of transfusions are complicated by adverse effects and in fact patients still die from fatal transfusion reactions.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Taswell, H.F., Pineda, A.A., Moore, S.B. Hemolytic transfusion reactions: frequency and clinical and laboratory aspects. In: Bell, C.A. (ed.) A seminar on immune-media ted cell destruction. Am. Assoc. Blood Banks, 1981, pp. 71–92.

    Google Scholar 

  2. Baker, R.J., Moinichen, S.L., Nyhus, L.M. Transfusion reaction: a reappraisal of surgical incidence and significance. Ann. Surg. 1969;169:684–93.

    Article  PubMed  CAS  Google Scholar 

  3. Honig, C.L., Bove, J.R. Transfusion-associated fatalities: Review of bureau of biologic reports 1976–1978. Transfusion 1980;20:631–61.

    Article  Google Scholar 

  4. Thulstrup, H. The influence of leukocyte and thrombocyte incompatibility on non-haemolytic transfusion reactions. Vox Sang 1971;21:233–50.

    Article  PubMed  CAS  Google Scholar 

  5. Brittingham, T.E., Chaplin, H. The antigenicity of normal and leukemic human leukocytes. Blood 1961;17:139–65.

    Google Scholar 

  6. Kevy, S.V., Schmidt, P.J., McGinniss, M.H., Workman, W.G. Febrile, nonhemolytic transfusion reactions and the limited role of leuko-agglutinins in their etiology. Transfusion 1962;2:27–16.

    Article  Google Scholar 

  7. Vyas, G.N., Holmdahl, L., Perkins, H.A., Fudenberg, H.H. Serologic specification of human anti-IgA and its significance in transfusion. Blood 1969;34:573–81.

    PubMed  CAS  Google Scholar 

  8. Mcleod, B.C., Sassetti, R.J., Weens, J.H., Vaithianathan, T. Haemolytic transfusion reaction due to ABO incompatible plasma in a platelet concentrate. Scand.J.Haematol. 1982;28:193–6.

    Article  PubMed  CAS  Google Scholar 

  9. Shulman, N.R., Aster, R.H., Leitner, A., Hiller, M.C. Immunoreactions involving platelets. V. Post-transfusion purpura due to a complement-fixing antibody against a genetically controlled platelet antigen. A proposed mechanism for thrombocytopenia and its relevance in autoimmunity. J. Clin. Invest. 1961;40:1597–1620.

    Article  PubMed  CAS  Google Scholar 

  10. Abramson, N., Eisenberg, P.D., Aster, R.H. Post-transfusion purpura: immunologic aspects and therapy. N. Engl. J. Med. 1974;291:1163–6.

    Article  PubMed  CAS  Google Scholar 

  11. Dutcher, J.P., Schiffer, CA., Aisner, J., Wiernik, P.H. Long-term follow-up of patients with leukemia receiving platelet transfusions: Identification of a large group of patients who do not become alloimmunized. Blood 1981;58:1007–11.

    PubMed  CAS  Google Scholar 

  12. Tejada, F., Bias, W.B., Santos, G.W., Zieve, P.D. Immunologic response of patients with acute leukemia to platelet transfusions. Blood 1973;42:405–12.

    PubMed  CAS  Google Scholar 

  13. Diepenhorst, P., Engelfriet, C.P. Removal of leukocytes from whole blood and erythrocyte suspensions by filtration through cotton wool. V. Results after transfusion of 1,820 units of filtered erythrocytes. Vox Sang 1975;29:15–22.

    Article  PubMed  CAS  Google Scholar 

  14. Sintnicolaas, K., Vriesendorp, H.N., Sizoo, W. et. al. Delayed alloimmunization by random single donor platelet transfusions. A randomized study to compare single donor and multiple donor platelet transfusions in cancer patients with severe thrombocytopenia. Lancet 1981;1:750–4.

    Article  PubMed  CAS  Google Scholar 

  15. Eernisse, J.G., Brand, A. Prevention of platelet refractoriness due to HLA antibodies by administration of leukocytepoor blood components. Exp. Hematol. 1981;9:77–83.

    CAS  Google Scholar 

  16. Djerassi, I., Kim, J.S., Suvansri, U., Ciesielka, W., Lohrke, J. Filtration leukopheresis: principles and techniques for harvesting and transfusion of filtered granulocytes and monocytes. In: Goldman, J.H., Lowenthal, R.M. (eds.) Leukocytes: separation, collection and transfusion. Academic Press, New York, 1975, pp. 123–36.

    Google Scholar 

  17. Higby, D.J., Freeman, A., Henderson, E.S., Sinks, L., Cohen, E. Granulocyte transfusions in children using filter-collected cells. Cancer 1976;38:1407–13.

    Article  PubMed  CAS  Google Scholar 

  18. Ward, H.N. Pulmonary infiltrates associated with leukoagglutinin transfusion reactions. Ann. Intern. Med. 1970;73:689–94.

    CAS  Google Scholar 

  19. Higby, D.J., Burnett, D. Granulocyte transfusions: current status. Blood 1980;55:2–8.

    PubMed  CAS  Google Scholar 

  20. Weiden, P.L., Zuckerman, N., Hansen, J.A., et. al. Fatal graft-versus-host disease in a patient with lymphoblastic leukemia following normal granulocyte transfusions. Blood 1981;57:328–32.

    PubMed  CAS  Google Scholar 

  21. Dinsmore, R.E., Straus, D.J., Pollack, M.S. et. al. Fatal graft-versus-host disease following blood transfusion in Hodgkin’s disease documented by HLA typing. Blood 1980;55:831–4.

    PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1984 Martinus Nijhoff Publishers, Boston

About this chapter

Cite this chapter

Sintnicolaas, K. (1984). Transfusion Reactions. In: Sibinga, C.T.S., Das, P.C., Taswell, H.F. (eds) Quality Assurance in Blood Banking and Its Clinical Impact. Developments in Hematology and Immunology, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2835-3_16

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-2835-3_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9791-8

  • Online ISBN: 978-1-4613-2835-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics