Current concepts in the treatment of esophageal cancer

  • David Kelsen
Part of the Cancer Treatment and Research book series (CTAR, volume 18)

Abstract

Malignant tumors of the esophagus are highly virulent neoplasms. In the United States, there has been no improvement in five year survival statistics over the past two decades, in spite of technical advances in both surgery and radiation therapy; only 5–10% of all newly diagnosed patients will be long-term survivors. Although relatively uncommon in the United States, the disease is endemic in other parts of the world. The vast majority of esophageal tumors are epidermoid carcinomas. In a study from Memorial Hospital involving 1,918 patients, Turnbull and his coleagues found that 95% had epidermoid cancer, with most of the other cases involving adenocarcinomas [1]. While most other series have noted a similar histologic pattern, occasionally up to 15% of patients were found to have adenocarcinomas [2]. Whether these studies have included large numbers of gastroesophageal cancers, or whether this represents an unusually large number of patients with adenocarcinoma arising in Barrett’s esophagus, is unclear. In either case, conventional treatment has been unsatisfactory, and intensive investigations in the epidemiology, early diagnosis, staging and treatment of patients with esophageal cancer are ongoing.

Keywords

Toxicity Adenocarcinoma Oncol Barium Folic Acid 

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Copyright information

© Martinus Nijhoff Publishers, Boston 1984

Authors and Affiliations

  • David Kelsen

There are no affiliations available

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