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Hepatitis B virus and hepatocellular carcinoma

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Clinical Management of Gastrointestinal Cancer

Part of the book series: Cancer Treatment and Research ((CTAR,volume 18))

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Abstract

In this chapter we propose to 1) review the data which supports the hypothesis that persistent infection with the hepatitis B virus (HBV) is required for the development of primary hepatocellular carcinoma (PHC), 2) discuss strategies for primary prevention of PHC, 3) present and discuss a cellular model for PHC in humans which describes the available data on the virus-cancer relation and provide a heuristic model for learning more about the pathogenesis of PHC. An objective of the use of the model and the greater knowledge of pathogenesis would be to develop methods for secondary prevention in persons who are already chronic carriers of HBV.

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Authors
  1. Baruch S. Blumberg
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  2. W. Thomas London
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Editor information

Editors and Affiliations

  1. Memorial Sloan-Kettering Cancer Center, New York, USA

    Jerome J. Decosse M.D.  & Paul Sherlock M.D.  & 

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© 1984 Martinus Nijhoff Publishers, Boston

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Blumberg, B.S., London, W.T. (1984). Hepatitis B virus and hepatocellular carcinoma. In: Decosse, J.J., Sherlock, P. (eds) Clinical Management of Gastrointestinal Cancer. Cancer Treatment and Research, vol 18. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2833-9_4

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  • DOI: https://doi.org/10.1007/978-1-4613-2833-9_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9790-1

  • Online ISBN: 978-1-4613-2833-9

  • eBook Packages: Springer Book Archive

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