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Epidermal and hair follicle transglutaminases and crosslinking in skin

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Transglutaminase

Part of the book series: Developments in Molecular and Cellular Biochemistry ((DMCB,volume 4))

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Summary

Epidermal and hair follicle transglutaminases crosslink structural proteins in the skin by epsilon-(gammaglutamyl)-lysine bonds. This crosslinking produces protein polymers that are extremely insoluble and, until recently, difficult to characterize.

Epidermal transglutaminase is localized to the granular layer of the epidermis. It catalyzes the crosslinking of a soluble cytoplasmic precursor to form the cornified envelope that lines the inner membrane of the mature keratinocyte in the stratum corneum.

Hair follicle transglutaminase is localized to the inner root sheath and medulla of the hair follicle. It crosslinks a poorly characterized citrulline-rich protein.

The enzymes and their substrates have been shown to be important markers of normal differentiation. Regulation of these processes is currently under investigation.

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Author information

Authors and Affiliations

  1. Dept. of Dermatology, The Oregon Health Sciences University, 3181 S. W. Sam Jackson Park Road, Portland, OR, 97201, USA

    Larry L. Peterson & Kirk D. Wuepper

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  1. Larry L. Peterson
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  2. Kirk D. Wuepper
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Editor information

Editors and Affiliations

  1. Division of Protein Chemistry, Tufts University School of Medicine, Boston, Massachusetts, USA

    Victor A. Najjar

  2. Department of Biochemistry, Molecular and Biology, Northwestern University College of Arts and Sciences, Evanston, Illinois, USA

    Laszlo Lorand

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© 1984 Martinus Nijhoff Publishing, Boston

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Peterson, L.L., Wuepper, K.D. (1984). Epidermal and hair follicle transglutaminases and crosslinking in skin. In: Najjar, V.A., Lorand, L. (eds) Transglutaminase. Developments in Molecular and Cellular Biochemistry, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2829-2_9

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  • DOI: https://doi.org/10.1007/978-1-4613-2829-2_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9788-8

  • Online ISBN: 978-1-4613-2829-2

  • eBook Packages: Springer Book Archive

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