Skip to main content

Features of Therapy-Related Leukemia and their Comparison with Leukemia de Novo and with the Blast Phase of Chronic Granulocytic Leukemia

  • Chapter
Human Leukemias

Part of the book series: Developments in Oncology Series ((DION,volume 14))

  • 42 Accesses

Abstract

Previous chapters have detailed the findings in acute nonlymphocytic leukemia (ANLL) de novo and in the blast phase of chronic granulocytic leukemia (CGL-BP). In this chapter we will discuss the morphologic, ultrastructural, and cytochemical characteristics of therapy-related or secondary myelodysplastic syndromes (2°-MDS) and ANLL (2°-ANLL), and we will compare these features with those of ANLL de novo and CGL-BP.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Pedersen-Bjergaard J, Larsen SO. Incidence of acute nonlymphocytic leukemia, preleukemia, and acute myeloproliferative syndrome up to 10 years after treatment of Hodgkin’s disease. New Engl J Med 307: 965–971, 1982.

    Article  PubMed  CAS  Google Scholar 

  2. Coleman CN, Burke J, Varghese A, Rosenburg S, Kaplan H. Secondary leukemia and non-Hodgkins lymphoma in patients treated for Hodgkins disease. In: Rosenberg S, Kaplan H. eds. Malignant lymphomas, Bristol Myers Cancer Symposia. vol 3. New York: Academic Press, 1982.

    Google Scholar 

  3. Greene MH, Boice JD, Greer BE, Blessing J A, Dembo AJ. Acute nonlymphocytic leukemia after therapy with alkylating agents for ovarian cancer: A study of five randomized clinical trials. New Engl J Med 307: 1416–1421, 1982.

    Article  PubMed  CAS  Google Scholar 

  4. Bergsagel DE, Bailey AJ, Langley GR, Mac Donald RN. White DF, Miller AB. The chemotherapy of plasma-cell myeloma and the incidence of acute leukemia. New Engl J Med 301: 743–748, 1979.

    Article  PubMed  CAS  Google Scholar 

  5. Bergsagel DE, Bailey AJ, Langley GR, Mac Donald RN. White DF, Miller AB. The chemotherapy of plasma-cell myeloma and the incidence of acute leukemia. New Engl J Med 301: 743–748, 1979.

    Article  PubMed  CAS  Google Scholar 

  6. Albain KS, LeBeau MM, Rowley JD, Golomb HM, Vardiman JW. Secondary acute nonlymphocytic leukemia (ANLL) and dysmyelopoietic syndrome (DMPS) in 46 patients: Clinical and cytogenetic correlations. Blood 60 isuppl 1): 119a. 1982, abstract 405.

    Google Scholar 

  7. Bennett JM, Catovsky D, Daniel MT, Flandrin G. Galton DAG. Gralnick HR, Sultan C. The French-American-British (FAB) Co-operative Group: Proposals for the classification of the myelodysplasia syndromes. Br J Haematol 51: 189–199, 1982.

    PubMed  CAS  Google Scholar 

  8. Rowley JD, Golomb HM. Vardiman JW. Nonrandom chromosome abnormalities in acute leukemia and dysmyelopoietic syndromes in patients with previously treated malignant disease. Blood 58:759–767, 1981.

    Google Scholar 

  9. Vardiman JW. Golomb HM. Rowley JD, Variakojis D. Acute nonlymphocytic leukemia in malignant lymphoma: A morphologic study. Cancer 42: 229–242, 1978.

    Article  PubMed  CAS  Google Scholar 

  10. Casciato DA, Scott JL. Acute leukemia following prolonged cytotoxic agent therapy. Medicine 58: 32–47, 1979.

    Article  PubMed  CAS  Google Scholar 

  11. Cadman EC. Capizzi RL. Bertino JR Acute nonlymphocytic leukemia: A delayed complication of Hodgkin’s disease therapy. Analysis of 109 cases. Cancer 40: 1280–1296, 1977.

    Article  PubMed  CAS  Google Scholar 

  12. Grunwald HW, Rosner F. Acute myeloid leukemia following treatment of Hodgkin’s disese: A review. Cancer 50: 676–683, 1982.

    Article  PubMed  CAS  Google Scholar 

  13. Pedersen-Bjergaard J, Philip P. Mortensen BT, Ersboll J. Jensen G, Panduro J, Thomsen M. Acute nonlymphocytic leukemia, preleukemia, and acute myeloproliferative syndrome secondary to treatment of other malignant diseases: Clinical and cytogenetic characteristics and results of in vitro culture of bone marrow and HLA typing. Blood 57: 712–723, 1981.

    Google Scholar 

  14. Dohy H. Genot JY, Imbert M, D’Agay MFR, Sultan C. Myelodysplasia and leukaemia related to chemotherapy and/or radiotherapy: A haematological study of 13 cases. Value of macrocytosis as an early sign of bone marrow injury. Clin Lab Haematol 2: 111–119, 1980.

    Google Scholar 

  15. Foucar K. McKenna RW, Bloomficld CD, Bowers TK, Brunning RD. Therapy- related leukemia: A panmyelosis. Cancer 43: 1285–1296, 1979.

    Article  PubMed  CAS  Google Scholar 

  16. O’Donnel JF. Brereton HD, Greco FA. Gralnick HR, Johnson RE. Acute nonlymphocytic leukemia achronic lymphocytic leukemia: Clinical studies. Cancer 44: 1930–1938, 1979.

    Article  Google Scholar 

  17. McKenna RW, Parkin JL. Foucar K. rerunning RD. Ultrastructural characteristics of therapy-related acute nonlymphocytic leukemia: Evidence for a panmyelosis. Cancer 48: 723–737, 1981.

    Article  Google Scholar 

  18. Renoux M, Bernard J, Torres M, Schlegel N, Amar M, Lopez M, Boivin P. Erythrocyte abnormalities induced by chemotherapy and radiotherapy: Induction of preleukaemic states? Scand I Haematol 21: 323–332. 1978.

    Article  CAS  Google Scholar 

  19. Pierre R, Sultan C, Vardiman J. Themyelodysplasric syndromes. In: McArthur JR. Hillman RS. eds. Hematology. 1982. Education Program of American Society of Hematology. The American Society of Hematology. 1982.

    Google Scholar 

  20. Vardiman JW, Coelho A. Golomb HM. Rowley J. Morphologic and cytochemical observations on the overt leukemic phase of therapy-related leukemia. Am J Clin Pathol, 79: 525–530. 1983.

    PubMed  CAS  Google Scholar 

  21. Kitahara M, Cosgriff TM, Eyre HJ. Sideroblastic anemia as a preleukemic event in patients treated for Hodgkin’s disease. Ann Intern Med 92: 625–627. 1980.

    PubMed  CAS  Google Scholar 

  22. Sultan C. Sigaux F, Imbert M, Reyes F. Acute myelodysplasia with myelofibrosis: A report of eight cases. Br J Haematol 49: 11–16, 1981.

    Article  PubMed  CAS  Google Scholar 

  23. Butler AE. Vardiman JW. Golomb HM. Ultrastructural characterization of de novo and secondary leukemias. Virchows Arch Cell Pathol39: 239–257, 1982.

    Google Scholar 

  24. Wickramasinghe SN. Bush V. Electron microscope and high resolution autoradiographic studies of megaloblastic erythropoiesis. Acta Haematol 57: 1–14. 1977.

    Article  PubMed  CAS  Google Scholar 

  25. Lewis SM. Frisch B. Congenital dyserythropoietic anemia: Electron microscopy. In: Porter R, Fitzsimons DW, eds. Congenital disorders of erythropoiesis. Ciba Foundation Symposium 37. Amsterdam, 1976.

    Google Scholar 

  26. Breton-Gorius J, Reyes F. Duhamel F. Najman A, Gorin NC. Megakarvoblastic acute leukemia: Identification by the ultrastructural demonstration of platelet peroxidase. Blood 51: 45–60, 1978.

    PubMed  CAS  Google Scholar 

  27. Bennett JM. Catovsky D. Daniel M. Flandrin G, Galton DAG. Gralnick HR, Sultan C. Proposals for the classification of the acute leukaemias: French-American-British (FAB) Co-operative Group. Br J Haematol 33: 451–458. 1976.

    Article  PubMed  CAS  Google Scholar 

  28. Lewis SM, Szur I. Malignant myelosclerosis Br Med J 2: 472–477, 1963.

    PubMed  CAS  Google Scholar 

  29. Bearman RM. Pangalis GA. Rappaport H. Acute (“malignant”) myelosclerosis. Cancer 43: 279–293, 1979.

    Article  PubMed  CAS  Google Scholar 

  30. Kaplan DR. Chao FC. Stiles CD. Antoniades HN, Scher CD Platelet a granules contain a growth factor for fibroblasts. Blood 53: 1043–1052, 1979.

    PubMed  CAS  Google Scholar 

  31. Groopman JE. The pathogenesis of myelofibrosis in myeloproliferative disorders. Ann Intern Med 92: 857–858. 1980.

    PubMed  CAS  Google Scholar 

  32. Breton-Gorius J. Bizet M, Reyes F, Dupuy E, Mear C, Vannier J, Tron P. Myelofibrosis and acute megakaryoblastic leukemia in a child: Topographic relationship between fibroblasts and megakaryocytes with an or-granule defect. Leuk Res 6: 97–110. 1982.

    Article  PubMed  CAS  Google Scholar 

  33. Bain BJ. Catovsky D, O’Brien M, Prentice HG, Lawlor E, Kumaran TO. McCann SR. Matures E. Galton DAG. Megakaryoblastic leukemia presenting as acute myelofibrosis: A study of four cases with the platelet- peroxidase reaction. Blood 58 206–213, 1981.

    PubMed  CAS  Google Scholar 

  34. Den Ottolander GJ. te Velde J. Brederoo P. Geraedts PM. Slee PHT. Willemze R. Zwaan FE, Haak HL. Muller HP, Bieger R. Megakaryoblastic leukemia (acute myelofibrosis): A report of three cases. Br F Haematol 42: 9–20. 1979.

    Article  Google Scholar 

  35. Berger R. Bernheim A. Daniel M, Valensi F. Sigaux F, Flandrin G. Cytologic characterization and significance ot normal karyotyes in t(8;21) acute mveloblastic leukemia. Blood 59: 171–178. 1982.

    PubMed  CAS  Google Scholar 

  36. Le Beau. M., Larson, R., Bitter, M., Vardiman, J.W., Golomb. H. and Rowley, JD. Association of an inversion of chromosome 16 with abnormal eosinophils in acute mvelomonocytic leukemia. N. Engl J Med 309: 630–636, 1983.

    Article  PubMed  Google Scholar 

  37. Miteiman F. Brandt L. Nilsson PG. Relation among occupational exposure to potential mutagenic/carcinogenic agents, clinical findings and bone marrow chromosomes in acute nonlymphocytic leukemia. Blood 52: 1229–1237. 1978.

    Google Scholar 

  38. Bain B. Catovsky D. O’Brien M. Spiers ASD, Richards HGH. Megakaryoblasticnd acute myeloproliferative syndrome following radiation therapy for non-Hodgkin’s lymphoma and transformation of chronic granulocytic leukaemia. J Clin Pathol 30: 235–242, 1977.

    Article  PubMed  CAS  Google Scholar 

  39. Breton-Gorius J, Reyes F, Vernant JP, Tulliez M. Dreyfus B. The blast crisis of chronic granulocytic leukaemia: Megakaryoblasric nature of cells as revealed by the presence of platelet-peroxidase. A cytocheinical ultrastructural studv. Br J Haematol 39: 295–303, 1978.

    Article  PubMed  CAS  Google Scholar 

  40. Rosenthal S, Cancllos GP. Gralnick HR. Erythroblastic transformation of chronic granulocytic leukemia. Am J Med 63:116–124, 1977.

    Google Scholar 

  41. Parkin JL, McKenna RW, Brunning RD. Philadelphia chromosome-positive blastic leukaemia: Ultrastructural and ultracytochemical evidence of basophil and mast cell differentiation. Br J Haematol 52: 663–677, 1982.

    Article  PubMed  CAS  Google Scholar 

  42. Prentice AF, Smith AG, Brandstock KF. Mixed lymphoblastic-myclomonoblastic leukemia in treated Hodgkin’s disease. Blood 56: 129–133. 1980.

    PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1984 Martinus Nijhoff Publishing, Boston/The Hague/Dordrecht/Lancaster

About this chapter

Cite this chapter

Vardiman, J.W., Bitter, M., Golomb, H. (1984). Features of Therapy-Related Leukemia and their Comparison with Leukemia de Novo and with the Blast Phase of Chronic Granulocytic Leukemia. In: Polliack, A. (eds) Human Leukemias. Developments in Oncology Series, vol 14. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2823-0_9

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-2823-0_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9785-7

  • Online ISBN: 978-1-4613-2823-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics