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Human Leukemias pp 393–402Cite as

Principles of the Freeze-Fracture Technique and Implications in Studies of Normal and CLL Lymphocytes

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Part of the book series: Developments in Oncology Series ((DION,volume 14))

Abstract

Functional Impairment of Membranes from CLL Lymphocytes. Investigations of the composition, structure, and function of the membrane of normal cells have been accompanied by examination of abnormalities in the plasma membranes of malignant cells. In chronic lymphocytic leukemia, diverse membrane-related functions of lymphocytes have been characterized as abnormal [1]. There is a decrease in the number of surface receptors for PHA [2] and concanavalin A [3] and decreased response to mitogens [4, 5]. Cells are unable to form caps with β2-microglobulin [6] concanavalin A [7], and antibodies to surface immunoglobulins [8], and exhibit impaired mobility in comparison to normal lymphocytes [9].

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Authors
  1. Carolyn S. Cody
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  2. Steven D. Douglas
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Editor information

Editors and Affiliations

  1. Lymphoma-Leukemia Unit, Hematology-Oncology Department, Hadassah University Hospital, Jerusalem, Israel

    Aaron Polliack M.D.

  2. Hadassah-Hebrew University Medical School, Jerusalem, Israel

    Aaron Polliack M.D.

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© 1984 Martinus Nijhoff Publishing, Boston/The Hague/Dordrecht/Lancaster

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Cody, C.S., Douglas, S.D. (1984). Principles of the Freeze-Fracture Technique and Implications in Studies of Normal and CLL Lymphocytes. In: Polliack, A. (eds) Human Leukemias. Developments in Oncology Series, vol 14. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2823-0_22

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  • DOI: https://doi.org/10.1007/978-1-4613-2823-0_22

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9785-7

  • Online ISBN: 978-1-4613-2823-0

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