Biphasic Action of Gossypol in Men

Abstract

Gossypol appears to have several advantages over other potential systemic contraceptives for use by men. Its action is independent of the hormonal events of the hypothalamo-hypophysial gonadal axis, so that a suppression of the testis¹ gamete-producing function can be achieved without suppressing the gonad’s hormone- producing function [1]. The range of reported side effects in men is far more limited than reported when hormonal steroids have been used experimentally for male contraception. The use of androgens, progestins, or combinations of the two by men has been associated with breast tenderness, gynecomastia, weight gain, loss of libido, changes in blood chemistry indicative of altered liver function and hemoconcentration [2]. None of these problems have been associated with the use of gossypol.