Gossypol pp 9-16 | Cite as

Trial of Gossypol as a Male Contraceptive

  • Guo-zhen Liu
  • Katherine C. Lyle
  • Jian Cao
Part of the Reproductive Biology book series (RBIO)

Abstract

In the 1950’s gossypol was identified as the cause of male infertility in many rural communes in China where ingestion of raw cotton seed oil was common. Since, then efforts have been made by the China National Coordinating Group on Male Anti- fertility Agents to develop this compound as a pill for men. If successful, gossypol could be a valuable addition to the existing methods of contraception. In the late 1960’s and early 1970’s, studies were undertaken to determine the toxic effects of gossypol in animals and in human beings. In 1972, a multicenter study, involving 14 centers and 8806 volunteers, was carried out to gather data on the efficacy, side-effects and clinical pharmacology of gossypol when used as a male contraceptive.

Keywords

Placebo Fatigue Toxicity Infertility Gossypol 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Guo-zhen Liu
    • 1
  • Katherine C. Lyle
    • 2
  • Jian Cao
    • 1
  1. 1.The Chinese Academy of Medical SciencesCapital HospitalBeijingThe People’s Republic of China
  2. 2.The Rockefeller FoundationUSA

Personalised recommendations