Trial of Gossypol as a Male Contraceptive
In the 1950’s gossypol was identified as the cause of male infertility in many rural communes in China where ingestion of raw cotton seed oil was common. Since, then efforts have been made by the China National Coordinating Group on Male Anti- fertility Agents to develop this compound as a pill for men. If successful, gossypol could be a valuable addition to the existing methods of contraception. In the late 1960’s and early 1970’s, studies were undertaken to determine the toxic effects of gossypol in animals and in human beings. In 1972, a multicenter study, involving 14 centers and 8806 volunteers, was carried out to gather data on the efficacy, side-effects and clinical pharmacology of gossypol when used as a male contraceptive.
KeywordsPlacebo Fatigue Toxicity Infertility Gossypol
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