The Use of the Portacaval Transposition Technique to Study Gastrointestinal and Hepatic Metabolism of Propranolol in Dogs
One of the drugs used extensively to validate the “well- stirred” perfusion model of hepatic drug clearance is propranolol. However, two of the basic assumptions of the model may not be met by propranolol. These are: 1) the liver is the only eliminating organ, and 2) the intrinsic clearance of propranolol is independent of drug concentration entering the liver, and therefore, metabolism is not capacity limited. To test,in vivo, whether or not these assumptions hold when a high first-pass drug such as propranolol is considered, we studied dogs before and after portacaval transposition.
KeywordsHepatic Metabolism Intrinsic Clearance Perfusion Model Hepatic Drug Clearance American Cyanamid Company
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