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Chemical Mutagens pp 165–181Cite as

The Bacillus subtilis Multigene Sporulation Test for Detection of Environmental Mutagens

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Abstract

The value of short-term in vitro screening tests for environmental mutagens is well established. It is generally agreed that a small battery of tests using both prokaryotic and eukaryotic cells should be used in preliminary screening to detect potential mutagens.(7) Bacterial tests are efficient and economical methods of detecting specific locus mutations. Moreover, well-developed methods of genetic manipulation make it easier to study mechanisms in bacteria. Tests for general genetic screening should be sensitive to a wide range of genetic damage and, if possible, representative of damage to the genome as a whole.

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Authors and Affiliations

  1. United States Department of Agriculture, Western Regional Research Center, Berkeley, California, 94710, USA

    L. E. Sacks & J. T. MacGregor

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  1. L. E. Sacks
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  2. J. T. MacGregor
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Editors and Affiliations

  1. National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA

    Frederick J. de Serres

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© 1984 Springer Science+Business Media New York

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Sacks, L.E., MacGregor, J.T. (1984). The Bacillus subtilis Multigene Sporulation Test for Detection of Environmental Mutagens. In: de Serres, F.J. (eds) Chemical Mutagens. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2771-4_5

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  • DOI: https://doi.org/10.1007/978-1-4613-2771-4_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9711-6

  • Online ISBN: 978-1-4613-2771-4

  • eBook Packages: Springer Book Archive

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