Abstract
Prostaglandin synthetase (PGS) catalyzes the oxygenation of polyunsaturated fatty acids to hydroxy endoperoxides (PGH) [1]. The most important substrate in vivo is arachidonic acid (AA). The PGS contains two activities. The fatty acid cyclooxygenase activity, catalyzes the oxygenation of arachidonic acid to a hydroperoxy endo- peroxide (PGG2), while the hydroperoxidase activity catalyzes the reduction of PGG2 to a hydroxy endoperoxide (PGH2) [2–3]. PGH2 represents a branch in the metabolism of arachidonic acid, and can undergo tissue specific metabolism, to different biological active substrates. PGS activity is present in different tissues. The highest activities have been found in seminal vesicles, platelets, lung and kidney while the activity in liver is quite low. The enzyme is associated with the endoplasmic reticulum and nuclear membranes, and is thus present in microsomal preparations.
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Moldéus, P., Andersson, B., Larsson, R., Nordenskjöldt, M. (1984). Involvement of Prostaglandin Synthetase in the Metabolic Activation of Chemical Carcinogens — Phenacetin as an Example. In: de Serres, F.J., Pero, R.W. (eds) Individual Susceptibility to Genotoxic Agents in the Human Population. Environmental Science Research, vol 30. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2765-3_7
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DOI: https://doi.org/10.1007/978-1-4613-2765-3_7
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