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On the Possible Significance of TCDD Receptor Based Assays in Attempts to Estimate Environmental Health Hazards

  • Chapter
Individual Susceptibility to Genotoxic Agents in the Human Population

Part of the book series: Environmental Science Research ((ESRH,volume 30))

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Abstract

Several attempts have been made and are being made to correlate individual responsiveness to certain health hazards with individual differences in inducibility of aryl hydrocarbon hydroxylase (AHH) activity [1–5]. Our approach to this problem is to attempt to measure the concentration of the cytosolic receptor (the 2,3,7,8-tetrachlorodibenzo-p-dioxin or TCDD receptor) believed to be involved in induction of AHH [6], rather than to study the enzyme induction [7–13]. From the field of steroid hormonal receptors we know that we can predict the responsiveness of individual cancer patients to hormonal therapy by monitoring their tumor content of steroid receptors [14–18]. It does not seem unreasonable to suggest that, by analogy, we might be able to predict an individual’s responsiveness to certain toxic agents by assaying that individual’s levels of receptor for the particular toxic chemical under study.

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Authors and Affiliations

  1. Department of Medical Nutrition Karolinska Institute, Huddinge University Hospital F69, S-141 86, Huddinge, Sweden

    Jan Åke Gustafsson, Jan Carlstedt-Duke, Mikael Gillner, Lars-Arne Hansson, Bertil Högberg, Johan Lund, Lorenz Poellinger & Rune Toftgård

  2. Department of Radiobiology Wallenberg Laboratory, University of Stockholm, S-106 91, Stockholm, Sweden

    Göran Löfroth

Authors
  1. Jan Åke Gustafsson
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  2. Jan Carlstedt-Duke
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  3. Mikael Gillner
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  4. Lars-Arne Hansson
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  5. Bertil Högberg
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  6. Johan Lund
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  7. Göran Löfroth
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  8. Lorenz Poellinger
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  9. Rune Toftgård
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Editors and Affiliations

  1. Research Triangle Park, National Institute of Environmental Health Sciences, North Carolina, USA

    Frederick J. de Serres

  2. University of Lund, Lund, Sweden

    Ronald W. Pero

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© 1984 Plenum Press, New York

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Gustafsson, J.Å. et al. (1984). On the Possible Significance of TCDD Receptor Based Assays in Attempts to Estimate Environmental Health Hazards. In: de Serres, F.J., Pero, R.W. (eds) Individual Susceptibility to Genotoxic Agents in the Human Population. Environmental Science Research, vol 30. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2765-3_5

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  • DOI: https://doi.org/10.1007/978-1-4613-2765-3_5

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