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References

  1. F. H. Sobels, in: Comparative Chemical Mutagenesis ( F. J. de Serres and M. D. Shelby, eds.), Plenum Press, New York (1981).

    Google Scholar 

  2. F. H. Sobels, in: Progress in Mutation Research, Elsevier/ North Holland, Amsterdam (1981).

    Google Scholar 

  3. H. V. Mailing, Perspectives in mutagenesis, Environ. Mutag., 3: 103–108 (1981).

    Article  Google Scholar 

  4. H. V. Mailing, Perspectives in mutagenesis, Environ. Mutag., 3: 103–108 (1981).

    Article  Google Scholar 

  5. B. Singer, N-nitroso alkylating agents: Formation and persistence of alkyl derivarives in mammalian nucleic acids as contributing factors in carcinogenesis, J. Natl. Cancer Inst., 62: 1329–1339 (1979).

    Google Scholar 

  6. G. A. Sega, R. B. Cummirig, and M. F. Walton, Dosimetry studies on the ethylation of mouse sperm DNA after in vivo exposure to [3H]ethyl methanesulfonate, Mutat. Res., 24: 317–333 (1974).

    Article  Google Scholar 

  7. W. R. Lee, Molecular dosimetry of chemical mutagens: Determination of molecular dose to the germ line, Mutat. Res., 38: 311–316 (1976).

    Google Scholar 

  8. C. S. Aaron, Molecular dosimetry of chemical mutagens: Selection of appropriate target molecules for determining molecular dose to the germ line, Mutat. Res., 38: 303–310 (1976).

    Google Scholar 

  9. W. R. Lee, Dosimetry of chemical mutagens in eukaryotic germ cells, in: Chemical Mutagens (A. Hollaender and F. J. de Serres, eds.), Vol. 5, pp. 117–202, Plenum Press, New York (1978).

    Google Scholar 

  10. C. S. Aaron, A. A. von Zeeland, G. R. Mohn, A. T. Natarajan, A. G. A. C. Knapp, A. D. Tates, and B. W. Glickman, Molecular dosimetry of the chemical mutagen ethyl methanesulfonate: Quantitative comparison of mutation induction in Escherichia coli, V79 Chinese hamster cells and L5178Y mouse lymphoma cells, and some cytological results in vitro and in vivo, Mutat. Res., 69: 201–216 (1980).

    Article  Google Scholar 

  11. S. A. Latt, J. Allen, S. E. Bloom, A. Carrano, E. Falke, D. Kram, E. Schneider, R. Schreck, R. Tice, B. Whitfield, and S. Wolff, Sister-chromatid exchanges: A report of the Gene- Tox Program, Mutat. Res., 87: 17–62 (1981).

    Google Scholar 

  12. F. D. de Serres and J. Ashby, eds., Short-Term Tests for Carcinogens: Report of the International Collaboration Program, Elsevier/North Holland, Amsterdam (1981).

    Google Scholar 

  13. A. Nettleship, P. S. Henshaw, and H. L. Meyer, Induction of pulmonary tumors in mice with ethyl carbamate (urethane), J. Natl. Cancer Inst., 4: 309–319 (1943).

    Google Scholar 

  14. International Agency for Research on Cancer, Some antithyroid and related substances, nitrofurans, and industrial chemicals, in: IARC Monograph on the Evaluation of the Carcinogenic Risks of Chemicals to Man, Urethane, 7:111–140, Lyon, France (1974).

    Google Scholar 

  15. R. H. Adamson and S. M. Sieber, in: Organ and Species Specificity in Chemical Carcinogenesis (R. Langenbach, S. Nesnow, and J. Rice, eds.), Vol. 24, pp. 129–156, Plenum Press, New York (1983).

    Google Scholar 

  16. A. W. Pound, F. Franke, and T. A. Lawson, The binding of ethyl carbamate to DNA of mouse liver in vivo: The nature of the bound molecule and the site of binding, Chem. Biol. Interact., 14: 149–163 (1976).

    Article  Google Scholar 

  17. J. W. Allen, Y. Sharief, and R. J. Langenbach, in: Genotoxic Effects of Airborne Agents ( R. Tice, D. Costa, and K. Schaich, eds.), pp. 443–460, Plenum Press, New York (1982).

    Chapter  Google Scholar 

  18. R. J. Preston, W. Au, M. A. Bender, J. G. Brewen, A. V. Carrano, J. A. Heddle, A. F. McFee, S. Wolff, and J. S. Wassom, Mammalian in vivo and in vitro cytogenetic assays: A report of the U.S. EPA’s Gene-Tox Program, Mutat. Res., 87: 143–188 (1981).

    Google Scholar 

  19. A. D. Bloom, ed., Guidelines for Studies of Human Populations Exposed to Mutagenic and Reproductive Hazards, March of Dimes Birth Defects Foundation, White Plains, New York (1981).

    Google Scholar 

  20. A. A. Sandberg, ed., Sister Chromatid Exchange, Alan R. Liss, Inc., New York (1982).

    Google Scholar 

  21. S. Wolff, ed., Sister Chromatid Exchange, John Wiley and Sons, New York (1982).

    Google Scholar 

  22. S. Wolff, ed., Sister Chromatid Exchange, John Wiley and Sons, New York (1982).

    Google Scholar 

  23. J. W. Allen, R. Langenbach, S. Nesnow, K. Sasseville, S. Leavitt, J. Campbell, K. Brock, and Y. Sharief, Comparative genotoxicity studies of ethyl carbamate and related chemicals: Further support for vinyl carbamate as a proximate carcinogenic metabolite, Carcinogenesis, 3: 1437–1441 (1982).

    Article  Google Scholar 

  24. J. W. Allen, C. F. Shuler, and S. A. Latt, Bromodeoxyuridine tablet methodology for in vivo studies of DNA synthesis, Somatic Cell Genet., 4: 393–405 (1978).

    Article  Google Scholar 

  25. A. F. McFee, K. W. Lowe, and J. R. San Sebastian, Improved sister-chromatid differentiation using paraffin-coated bromo-deoxyuridine tablets in mice, Mutat. Res., 119: 83–88 (1983).

    Article  Google Scholar 

  26. J. W. Allen, E. El-Nahass, M. K. Sanyal, R. L. Dunn, B. Gladden, and R. L. Dixon, Sister-chromatid exchange analysis in rodent maternal, embryonic, and extra-embryonic tissues: Transplacental and direct mutagen exposures, Mutat. Res., 80: 297–311 (1981).

    Article  Google Scholar 

  27. R. J. Albertini and R. DeMars, Detection and quantification of X-ray induced mutation in cultured diploid human fibroblasts, Mutat. Res., 18: 199–224 (1973).

    Article  Google Scholar 

  28. J. H. Taylor, Asynchronous duplication of chromosomes in cultured cells of Chinese hamster, J. Biophys. Biochem. Cytol., 7: 455–467 (1960).

    Article  Google Scholar 

  29. S. Bader, 0. T. Miller, and B. B. Mukherjee, Observations on chromosome duplication in cultured human leucocytes, Exp. Cell Res., 31: 100–112 (1963).

    Article  Google Scholar 

  30. Y. Kikuchi and A. A. Sanberg, Chronology and pattern of human chromosome replication, 1., Blood leucocytes of normal subjects, J. Natf1. Cancer Inst., 32: 1109–1143 (1964).

    Google Scholar 

  31. G. C. Mueller and K. Kajiwara, Early- and late-replicating deoxyribonucleic acid complexes in HeLa nuclei, Biochim. Biophys. Acta, 114: 108–119 (1966).

    Google Scholar 

  32. B. B. Mukherjee, W. C. Wright, S. K. Ghosal, G. D. Burkhalder, and K. E. Mann, Further evidence for the simultaneous initiation of DNA repliation in both X chromosomes of bovine female, Nature (London), 220: 714–716 (1968).

    Article  ADS  Google Scholar 

  33. R. Braun and H. Willi, Time sequence of DNA replication in phyarium, Biochim. Biophys. Acta, 174: 246–252 (1969).

    Google Scholar 

  34. S. L. Huang, S. M. S. Huang, C. Casperson, and M. D. Waters, Induction of 6-thioguanine resistance in synchronized human fibro- blast cells treated with methyl methanesulfonate, N-acetoxy- 2-acetylaminofluorene and N-methyl-Nf-nitro-N-nitrosoguanidine, Mutat. Res., 83: 251–260 (1981).

    Article  Google Scholar 

  35. G. E. Milo and J. A. DiPaolo, Neoplastic transformation of human diploid cells in vitro after chemical carcinogen treatment, Nature (London), 275: 130–132 (1978).

    Article  ADS  Google Scholar 

  36. V. M. Maher and J. E. Wessel, Mutation to azaguanine resistance induced in cultured diploid human fibroblasts by the carcinogen, N-acetoxy-2-acetylaminofluorene, Mutat. Res., 28: 277–284 (1975).

    Article  Google Scholar 

  37. L. Jacobs and R. DeMars, Quantification of chemical mutagenesis in diploid human fibroblasts: Induction of azaguanine-resistant mutants by N-methyl-N’-nitro-N-nitrosoguanidine, Mutat. Res., 53: 29–53 (1978).

    Google Scholar 

  38. L. Jacobs and R. DeMars, in: Handbook of Mutagenicity Test Procedures ( B. J. Kilbey, ed.), Elsevier, Amsterdam (1977).

    Google Scholar 

  39. S. L. Huang and M. W. Lieberman, Induction of 6-thioguanine resistance in human cells treated with N-acetoxy-2-acetylamino- fluorene, Mutat. Res., 57: 349–358 (1978).

    Google Scholar 

  40. G. H. Strauss and R. J. Albertini, Enumeration of 6-thioguan- ine-peripheral blood lymphocytes in man as a potential test for somatic cell mutations arising in vivo, Mutat. Res., 61: 353–379 (1979).

    Article  Google Scholar 

  41. G. H. S. Strauss, in: The Use of Human Cells for the Assessment of Risk from Physical and Chemical Agents ( A. Castellani, ed.), Plenum Press, New York (1982).

    Google Scholar 

  42. G. H. Strauss, R. J. Albertini, and B. J. Allen, An enumerative assay of purine analog resistant lymphocytes in women heterozygous for the Lesch-Nyhan mutation, Biochem. Genet., 18: 529–547 (1980).

    Article  Google Scholar 

  43. G. H. S. Strauss, in: Indicators of Genotoxic Exposures in Man and Animals (B. A. Bridges, B. E. Butterworth, and I. B. Weinstein, eds.), Banbury Report 13, Cold Spring Harbor Laboratory (1982).

    Google Scholar 

  44. D. Clive, W. G. Flamm, M. R. Machesko, and N. J. Bernheim, A mutational assay system using the thymidine kinase locus in mouse lymphoma cells, Mutat. Res., 16: 77–87 (1972).

    Article  Google Scholar 

  45. D. Clive and P. Voytek, Evidence for chemically-induced structural gene mutations at the thymidine kinase locus in cultured L5178Y mouse lymphoma cells, Mutat. Res., 44: 69–278 (1977).

    Google Scholar 

  46. N. T. Turner, A. G. Batson, and D. Clive (in preparation).

    Google Scholar 

  47. D. Clive and J. F. S. Spector, Laboratory procedure for assessing specific locus mutations at the TK locus in cultured L5178Y mouse lymphoma cells, Mutat. Res., 31: 17–29 (1975).

    Google Scholar 

  48. J. Hozier, J. Sawyer, M. Moore, B. Howard, and D. Clive, Cytogenetic analysis of the L5178Y/TK+/- → TK-/- mouse lumphoma mutagenesis assay system, Mutat. Res., 84: 169–181 (1981).

    Article  Google Scholar 

  49. J. Hozier, J. Sawyer, D. Clive, and M. Moore, Cytogenetic dis¬tinction between the TK+ and TK- chromosome in the L5178Y TK+/- mouse lymphoma mutagenesis assay system, Mutat. Res., 105:451–456 (1982).

    Article  Google Scholar 

  50. J. Hozier, J. Sawyer, D. Clive, and M. Moore, Cytogenetic dis¬tinction between the TK+ and TK- chromosome in the L5178Y TK+/- mouse lymphoma mutagenesis assay system, Mutat. Res., 105:451–456 (1982).

    Article  Google Scholar 

  51. E. Yamasaki and B. N. Ames, Concentration of mutagens from urine by adsorption with the non-polar resin XAD-2: Cigarette smokers have mutagenic urine, Proc. Natl. Acad. Sci. (U.S.A.), 74: 3555 - 3559 (1977).

    Article  ADS  Google Scholar 

  52. M. S. Legator, E. Bueding, R. Butzinger, T. H. Conner, E. Eisenstadt, M. G. Farrow, G. Ficsor, A. Hsie, J. Seed, and R. S. Stafford, An evaluation of the host-mediated assay and body fluid analysis: A report of the U.S. Environment Protection Agency Gene-Tox Program, Mutat. Res., 98: 319–374 (1982).

    Google Scholar 

  53. A. G. Stead, V. Hasselblad, J. P. Creason, and L. Claxton, Modeling the Ames test, Mutat. Res., 85: 12–27 (1981).

    Google Scholar 

  54. D. E. Jenson, Reaction of DNA with alkylating agents, Differential alkylation of poly DA-DT by methylnitrosourea and ethyl- nitrosourea, Biochemistry, 17: 5108–5113 (1978).

    Article  Google Scholar 

  55. P. Brooks and P. D. Lawley, in: Chemical Mutagens, Principles, and Methods for Their Detection (A. Hollaender, ed.), Vol. 1, pp. 121–144, Plenum Press, New York.

    Google Scholar 

  56. B. Singer, W. J. Bodell, J. E. Cleaver, G. H. Thomas, M. F. Rajewsky, and W. Thon, Oxygens in DNA are main targets for ethylnitrosourea in normal and xeroderma pigmentosum fibroblasts and fetal rat brain cells, Nature, 276: 85–88 (1978).

    Article  ADS  Google Scholar 

  57. A. V. Connors, P. J. Cox, P. B. Farmer, A. B. Foster, and M. Jarman, Some studies of the active intermediates formed in the microsomal metabolism of cyclophosphamide and isophosphamide, Biochem. Pharmacol., 23: 115 (1974).

    Article  Google Scholar 

  58. L. S. Goodman and A. Gilman, The Pharmacological Basis of Therapeutics, Macmillan, New York (1975).

    Google Scholar 

  59. International Agency for Research on Cancer, Chemicals and Industrial Processes Associated with Cancer in Humans, IARC Monographs, Supplement 4 to Vols. 1–29, Lyon, France (1982).

    Google Scholar 

  60. International Agency for Research on Cancer, IARC Monographs, Vol. 9, Lyon, France, 135–156 (1975).

    Google Scholar 

  61. T. Raposa, Sister chromatid exchange studies for monitoring DNA damage and repair capacity after cytostatics in vitro and in lymphocytes of leukaemic patients under cytostatic therapy, Mutat. Res., 57: 241 (1978).

    Article  Google Scholar 

  62. E. Schmid and M. Bauchinger, Chromosomenaberrationen in mensch- lichen peripheren lymphozyten nach endoxanstosstherapie gyn- akologischer tumoren, Deutsche Medizinische Wochenschrift, 93: 1149 (1968).

    Article  Google Scholar 

  63. F. E. Arrighi, T. C. Hsu, and D. E. Bergsagel, Chromosome damage in murine and human cells following Cytoxan therapy, Tex. Rep. Biol. Med., 20: 545 (1962).

    Google Scholar 

  64. E. Schmid and M. Bauchinger, Comparison of the chromosome damage induced by radiation and Cytoxan therapy in lymphocytes of patients with gynaecological tumors, Mutat. Res., 21: 271 (1973).

    Article  Google Scholar 

  65. M. Bauchinger and E. Schmid, Cytogenetische veranderungen in weissen blutzellen nach cyclophosphamidtherapie, Z. Krebsforsch., 72: 77 (1969).

    Article  Google Scholar 

  66. M. Dobos, D. Schuler, and G. Fekete, Cyclophosphamide-induced chromosomal aberrations in nontumorous patients, Humangenetik, 22: 221 (1974).

    Google Scholar 

  67. R. L. Wall and K. P. Clausen, Carcinoma of the urinary bladder in patients receiving cyclophosphamide, New England J. Med., 293: 271–273 (1975).

    Article  Google Scholar 

  68. G. T. Roberts and J. W. Allen, Tissue-specific induction of sister chromatid exchanges by ethylcarbamate in mice, Environ. Mutag., 2: 17–26 (1980).

    Article  Google Scholar 

  69. G. T. Roberts and J. W. Allen, Tissue-specific induction of sister chromatid exchanges by ethylcarbamate in mice, Environ. Mutag., 2: 17–26 (1980).

    Article  Google Scholar 

  70. S. S. Mirvish, The carcinogenic action and metabolism of urethane and N-hydroxyurethane, Adv. Cancer Res., 11: 1–42 (1968).

    Article  Google Scholar 

  71. G. A. Dahl, J. A. Miller, and E. C. Miller, Vinyl carbamate as a promutagen and a more carcinogenic analysis of ethyl carbamate, Cancer Res., 38: 3793–3804 (1978).

    Google Scholar 

  72. G. A. Dahl, E. C. Miller, and J. A. Miller, Comparative carcinogenicities and mutagenicities of vinyl carbamate, ethyl carbamate, and ethyl N-hydroxycarbamate, Cancer Res., 40: 1194–1203 (1980).

    Google Scholar 

  73. M. L. Ribovich, J. A. Miller, E. C. Miller, and L. G. Timmins, Labeled 1, N°-ethenoadenosine and 3,N4-ethenocytidine in hepatic RNA of mice given [ethyl–l,2-3H or ethyl-l-14C] ethyl carbamate (urethan), Carcinogenesis, 3: 539–546 (1982).

    Article  Google Scholar 

  74. J. W. Allen, R. Langenbach, S. Leavitt, Y. Sharief, J. Campbell, and K. Brock, in: Indicators of Genotoxic Exposure in Man and Animals (B. A. Bridges, B. E. Butterworth, and I. B. Weinstein, eds.), Banbury Report 13, Cold Spring Harbor Laboratory (1982).

    Google Scholar 

  75. C. A. Kozak and F. H. Ruddle, Assignment of the genes for thymidine kinase and galactokinase to Mus musculus chromosome 11 and the preferential segregation of this chromosome in Chinese hamster/mouse lymphoma somatic cell hybrids, Somat. Cell Genet., 3: 121–133 (1977).

    Article  Google Scholar 

  76. C. Doerr and M. Moore, unpublished.

    Google Scholar 

  77. S. M. Morris, R. H. Heflich, R. L. Kodell, and D. T. Beranek, Induction of sister-chromatid exchanges in Chinese hamster ovary cells by simple methylating agents: Relationship to specific DNA adducts, Abstracts of the Fourteenth Annual Meeting of the Environmental Mutagenic Society, p. 98, San Antonio, Texas, March 3–6, 1983.

    Google Scholar 

  78. H. Fraenkel-Conrat and B. Singer, Effect of introduction of small alkyl groups on mRNA function, Proc. Natl. Acad. Sci. (U.S.A.), 77: 1983–1985 (1980).

    Article  ADS  Google Scholar 

  79. M. D. Topal and M. S. Baker, DNA precursor pool: A significant target for N-methyl-N-nitrosourea in C3H/10T1/2 clone 8 cells, Proc. Natl. Acad. Sci. (U.S.A.), 79:2211–2215 (1982).

    Article  ADS  Google Scholar 

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Waters, M.D. et al. (1984). Evaluation of Genotoxic Effects in Human Populations. In: de Serres, F.J., Pero, R.W. (eds) Individual Susceptibility to Genotoxic Agents in the Human Population. Environmental Science Research, vol 30. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2765-3_4

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