Influence of Demographic Factors on Scheduled DNA Synthesis as Measured in Human Peripheral Leukocytes and Fibroblasts

  • John J. Madden
  • Arthur Falek
  • David A. Shafer
  • Robert M. Donahoe
  • Deborah C. Eltzroth
  • Felicia Hollingsworth
  • Peter J. Bokos
Part of the Environmental Science Research book series (ESRH, volume 30)


In a population study of leukocytes from 140 human subjects, far UV-induced unscheduled DNA synthesis (UDS) variation correlated with at least three demographic factors — smoking tobacco, season of sample obtainment and “street opiate” addiction. The ability to correlate UDS variability with these factors demonstrates the importance of environmental influences in control of DNA repair processes and the need to include the effect of demographics in genetic risk assessment models. In addition, mutagen-induced UDS patterns for mononuclear leukocytes from a single subject did not match the UDS pattern for fibroblasts grown from a forearm skin biopsy from the same individual which suggests that UDS may be tissue specific.


Repair Capacity Risk Assessment Model Mononuclear Leukocyte Heroin Addiction Opiate Addiction 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • John J. Madden
    • 1
    • 2
    • 3
  • Arthur Falek
    • 1
    • 2
  • David A. Shafer
    • 1
    • 2
  • Robert M. Donahoe
    • 1
    • 2
  • Deborah C. Eltzroth
    • 1
    • 2
  • Felicia Hollingsworth
    • 1
    • 2
  • Peter J. Bokos
    • 4
  1. 1.Dept. of PsychiatryEmory UniversityAtlantaUSA
  2. 2.Human and Behavioral Genetics Research LaboratoryGeorgia Mental Health InstituteAtlantaUSA
  3. 3.Dept. BiochemistryEmory UniversityAtlantaUSA
  4. 4.InterventionsChicagoUSA

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