Abstract
Most mutagens and cancer initiators (“genotoxic agents” [1]) are electrophilic, mainly alkylating, reactants, or are metabolized to such [2]. Large numbers of pollutants in air, water, foods (also natural constituents [3]) are potentially genotoxic. The induction of genotoxic effects is a stochastic process with a raised risk at very low levels or doses [1]. Due to a low resolving power [4] of epidemiological studies and laboratory experiments, the identification and estimation of genotoxic risks to man becomes a difficult problem [5]. To this adds our imperfect knowledge of the metabolism of foreign compounds, leading to an uncertainty with regard to the relationship between level of exposure and in vivo dose of ultimate genotoxic reactants.
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© 1984 Plenum Press, New York
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Jensen, S., Törnqvist, M., Ehrenberg, L. (1984). Hemoglobin as a Dose Monitor of Alkylating Agents Determination of Alkylation Products of N-Terminal Valine. In: de Serres, F.J., Pero, R.W. (eds) Individual Susceptibility to Genotoxic Agents in the Human Population. Environmental Science Research, vol 30. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2765-3_19
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DOI: https://doi.org/10.1007/978-1-4613-2765-3_19
Publisher Name: Springer, Boston, MA
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