Summary
Chromosome analysis was carried out on peripheral blood lymphocytes from 12 women at 0, 1, and 4 weeks. Two women were also consecutively sampled for 2 years. The mean rate for chromatid breaks was 3.0% range 0–13 and for gaps 8.7% range 2–21.
The intra-individual fluctuations were as great as the inter-individual variations. The increases in the aberration yield could not be correlated with the phase of the menstrual cycle, the mitotic index or with any clinically manifest infection.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
K. E. Buckton, G. E. Hamilton, L. Paton, and A. O. Langlands, Chromosome aberrations in irradiated Ankylosing spondylitis patients, in: Mutagen-Induced Chromosome Damage in Man (H. J. Evans and D. C. Lloyd, eds.), 142–150, Edinburgh Univ. Press, Edinburgh.
F. Funes-Cravioto, B. Lambert, J. Lindsten, L. Ehrenberg,A. T. Natarajan, and S. Osterman-Golker, Chromosome aberrations in workers exposed to vinyl chloride, Lancet, 1:459–461 (1975).
B. A. Kihlman, K. Hansson, F. Palitti, H. C. Andersson, and B. Hartley-Asp, Potentiation of induced chromatid-type aberrations by hydroxyurea and caffeine in G2, in: Progress in Mutation Res., Vol. 4 (A. T. Natarajan, G. Obe, and H. Altman, eds.), 11–24, Elsivier North Holland (1982).
A. T. Natarajan, G. Obe, and F. N. Dalout, The effect of caffeine post-treatment on X-ray-induced chromosomal aberrations in human blood lymphocytesin vitro, Hum. Genetics, 54:183–189 (1980).
H. A. Lubs and J. Samuelson, Chromosome abnormalities in lymphocytes from normal human subjects, Cytogenetics, 6:402–411 (1967).
S. Aymé, J. F. Mattei, M. G. Mattei, Y. Aurran, and F. Giraud, Non-random distribution of chromosome breaks in cultured lymphocytes of normal subjects, Hum. Genet., 31:161–175 (1976).
L. G. Littlefield and K. 0. Gok, Cytogenetic studies in control men and women. I. Variations in aberration frequencies in 29,709 metaphases from 305 cultures obtained over a three-year period, Cytogenet. Cell Genet., 12 17–34 (1973).
H. J. Evans and M. L. O’Riordan, Human peripheral blood lymphocytes for the analysis of chromosome aberrations in mutagen tests, Mutation Res., 31:135–148 (1975).
J. A. Di Paolo and N. C. Popescu, Relationships of chromosome changes to neoplastic cell transformation, Am. J. Pathol., 85: 709–738 (1976).
A. Schinzel and W. Schmid, Lymphocyte chromosome studies in humans exposed to chemical mutagens: The validity of the method in 67 patients under cytostatic therapy, Mutation Res., 40:139–166 (1976).
E. Gebhart, Experimentelle Beitrage zum problem der lokalen achromasien (Gaps), Hum. Genet., 13:98–107 (1971).
D. Anderson and C. R. Richardson, Issues relevant to the assessment of chemically induced chromosome damagein vivoand and their relationship to chemical mutagenesis, Mutation Res., 90:261–272 (1981).
G. Obe and J. Herha, Chromosomal aberrations in heavy smokers, Hum. Genet., 41:259–263 (1978).
P. E. Crossen and W. F. Morgan, Lymphocyte proliferation in Down’s Syndrome measured by sister chromatid differential staining, Hum. Genet., 53:311–313 (1980).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1984 Plenum Press, New York
About this chapter
Cite this chapter
Hartley-Asp, B. (1984). Variations in Mitotic Index and Chromosomal Aberration Rates in Women. In: de Serres, F.J., Pero, R.W. (eds) Individual Susceptibility to Genotoxic Agents in the Human Population. Environmental Science Research, vol 30. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2765-3_12
Download citation
DOI: https://doi.org/10.1007/978-1-4613-2765-3_12
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-9709-3
Online ISBN: 978-1-4613-2765-3
eBook Packages: Springer Book Archive