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Individual Variability in the Frequency of Sister Chromatid Exchange in Human Lymphocytes

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Individual Susceptibility to Genotoxic Agents in the Human Population

Part of the book series: Environmental Science Research ((ESRH,volume 30))

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Abstract

Sister chromatid exchange (SCE) can be demonstrated in metaphase cells by autoradiographic techniques [1] or by more recently developed staining techniques [2]. Although the mechanism(s) and the nature of the alterations leading to SCE are largely unknown, there are a number of observations suggesting a relationship between mutagenic and/or carcinogenic damage and an increased rate of SCEs [3]. Firstly there is a linear correlation between the induction of SCE and single gene mutation for many chemical agents, and both of these events show a similar spontaneous rate of occurrence over the entire genome [4]. Secondly, a great number of mutagens and carcinogens have been shown to induce SCEs, in some cases at very low concentrations, in various mammalian cellsin vitro as well asin vivo [5, 6]. Finally, the induction of SCE is S-phase dependent, and appears to be closely related to DNA replication [3].

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Author information

Authors and Affiliations

  1. Department of Clinical Genetics, Karolinska Hospital, 104 01, Stockholm, Sweden

    Bo Lambert

  2. Royal Institute of Technology, 100 44, Stockholm, Sweden

    Robert Olin

  3. ASTRA Inc, 151 85, Södertälje, Sweden

    Robert Olin

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  1. Bo Lambert
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  2. Robert Olin
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Editors and Affiliations

  1. Research Triangle Park, National Institute of Environmental Health Sciences, North Carolina, USA

    Frederick J. de Serres

  2. University of Lund, Lund, Sweden

    Ronald W. Pero

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© 1984 Plenum Press, New York

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Lambert, B., Olin, R. (1984). Individual Variability in the Frequency of Sister Chromatid Exchange in Human Lymphocytes. In: de Serres, F.J., Pero, R.W. (eds) Individual Susceptibility to Genotoxic Agents in the Human Population. Environmental Science Research, vol 30. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2765-3_11

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  • DOI: https://doi.org/10.1007/978-1-4613-2765-3_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9709-3

  • Online ISBN: 978-1-4613-2765-3

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