Abstract
The question to be addressed in this paper, namely are there individuals who are hypersensitive, or who are more likely to be hypersensitive, to the induction of chromosome aberrations by radiation and chemicals, is, at this time, difficult to answer. Furthermore, if such individuals can be identified there are social and legal implications concerning what action, if any, should be taken as far as their occupational or medical status is concerned. This will not be discussed here, as it is felt that such a topic is outside the domain of the author, a cytogeneticist. While the emphasis will be on factors that could contribute to an increased sensitivity, it is also appropriate to consider if there are also factors that could contribute to a decreased sensitivity to chromosome aberration induction. Some of the discussion regarding DNA repair will be abbreviated, because much more detail can be found in the paper given by Dr. James Cleaver at this same Workshop.
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Preston, R.J. (1984). Intrinsic Factors that can Affect Sensitivity to Chromosome Aberration Induction. In: de Serres, F.J., Pero, R.W. (eds) Individual Susceptibility to Genotoxic Agents in the Human Population. Environmental Science Research, vol 30. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2765-3_10
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