Abstract
There is a paradox in discussing the use of occupational experience in relation to individual susceptibility to genotoxic agents. First, disease that is seen occurs in individuals, and reflects their individual susceptibility. The research that is done, however, is focused on populations. Therefore, in this presentation I will move from one foot to the other. Secondly, there’s long been a curious dichotomy with regard to reproductive experience and occupational and environmental health matters. Curious, because there’s been a concordance in many ways. In each, both somatic and genetic material are included, many species can be affected, many different organs, different tissues, and both are very selective within populations. A large variety of agents can affect individuals in each, both males and females can be involved. Yet this dichotomy has continued.
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References
I. J. Selikoff and E. C. Hammond, eds., Toxicity of Vinyl Chloride and Polyvinyl Chloride, Annals of The New York Academy of Sciences, New York, Vol. 246 (1975).
A. Ducatman, K. Hirschhorn, and I. J. Selikoff, Vinyl chloride exposure and human chromosome aberrations, Mutat. Res., 31: 163–168 (1975).
I. J. Selikoff, Scientific basis for control of environmental health hazards, in: Public Health and Preventive Medicine, 11th edition ( J. M. Last, ed.), Appleton-Century-Crofts, New York (1980), pp. 529–542.
M. Hartung, H.-H. Schaller, and E. Brand, On the question of the pathogenetic importance of cobalt for hard metal fibrosis of the lung, Intl. Arch. Occup. Environ. Health, 50: 53–57 (1982).
E. C. Hammond, Smoking in relation to the death rates of one million men and women, in: Epidemiological study of cancer and other chronic diseases, Monograph 19, Bethesda, Maryland, National Cancer Institute (1966).
P. Pott, Cancer of the scrotum. Chirurgical Observations, Hawes, Clark, and Collings, London, 1775, pp. 63–68.
L. Rehn, Blasengeschwulste bei Fuchsin in Arbritern, Arch. Klin. Chirugie, 50: 588–600, 1895.
G. H. Gehrmann, The carcinogenetic agent — chemistry and in¬dustrial aspects, J. Urology, 31 (2): 126–137 (1934).
I. J. Selikoff, Asbestos-associated disease, in: Maxcy-Rosenau Public Health and Preventive Medicine, 11th ed. ( J. Last, ed. ), Appleton-Century-Crofts (1980), pp. 568–644.
K. M. Lynch and W. A. Smith, Pulmonary asbestosis. III. Car¬cinoma of lung in asbestos-silicosis, Am. J. Cancer, 24: 56 (1935).
I. J. Selikoff, J. Churg, and E. C. Hammond, The occurrence of asbestosis among insulation workers in the United States, Ann. N.Y. Acad. Sci., 132: 139–155 (1965).
I. J. Selikoff, J. Churg, and E. C. Hammond, Asbestos exposure and neoplasia, JAMA, 188: 22–26 (1964).
E. Mayr, The Growth of Biological Thought, Harvard University Press, Cambridge (1982), pp. 974.
R. Doll, Avoidable cancer: attribution of risk, So. Afr. Ca. Bull., 25 (3): 125–126 (1981).
I. J. Selikoff, E. C. Hammond, and H. Seidman, Mortality experience of insulation workers in the United States and Canada, Ann. N.Y. Acad. Sci., 330: 91–116 (1979).
I. J. Selikoff, E. C. Hammond, and H. Seidman, Latency of asbestos disease among insulation workers in the United States and Canada, Cancer 46: 2736–2740 (1980).
I. J. Selikoff, H. Seidman, and E. C. Hammond, Mortality effects of cigarette smoking among amosite asbestos factory workers, J. Natl. Cancer Inst., 65 (3): 507–513 (1980).
H. Seidman, I. J. Selikoff, and E. C. Hammond, Short-term asbestos work exposure and long-term observations, Ann. N.Y. Acad. Sci., 330: 61–89 (1979).
I. J. Selikoff, E. C. Hammond, and J. Churg, Asbestos exposure, smoking and neoplasia, JAMA, 204 (2): 106–112 (1968).
E. C. Hammond, I. J. Selikoff, and H. Seidman, Asbestos exposure, cigarette smoking and death rates, Ann. N.Y. Acad. Sci., 330: 473–490 (1979).
J. G. Bekesi, J. P. Roboz, A. Fischbein, and I. J. Selikoff, Immune dysfunction due to xenobiotics, Presented at the Second Intl. Conf. on Immunopharmacology, Washington, D.C. (July 5–10, 1982 ).
P. Klemperer and C. B. Rabin, Primary neoplasms of the pleura, A report of five cases, Arch. Path., 11: 385–412 (1931).
J. C. Wagner, C. A. Sleggs, and P. Marchand, Diffuse pleural mesothelioma and asbestos exposure in the North Western Cape Province, Brit. J. Indust. Med., 17: 260 (1960).
Y. I. Baris, L. Simonato, R. Saracci, et al., Malignant mesothelioma and radiological chest abnormalities in two villages in central Turkey, Lancet, 2: 984–997 (1981).
A. N. Rohl, A. M. Langer, G. Moncure, I. J. Selikoff, and A. Fischbein, Endemic pleural disease associated with exposure to mixed fibrous dust in Turkey, Science, 216: 518–520 (1982).
J. C. Cochrane and I. Webster, Mesothelioma in relation to asbestos fibre exposure, So. Afr. Med. J., 59 (24): 848 (1981).
M. L. Newhouse and H. Thompson, Mesothelioma of pleura and peritoneum following exposure to asbestos in the London area. Brit. J. Indus. Med., 22: 261 (1965).
I. J. Selikoff, Practical questions for practical politicians, Ann. N.Y. Acad. Sci., 387: 1–9 (1982).
M. S. Wolff, H. A. Anderson, and I. J. Selikoff, Human tissue burdens of halogenated aromatic chemicals in Michigan, JAMA, 247: 2112–2116 (1982).
D. Rail, Relevance of results from laboratory animal toxi¬cology studies, in: Maxcy-Rosenau, Public Health and Preventive Medicine, 11th Edition, Appleton-Century-Crofts (1980), pp. 543–549.
I. J. Selikoff, The regulations debate: deciding whether people live or die, CUNY Graduate School Magazine, 1 (2): 12–19 (1982).
I. J. Selikoff, Multiple factor interaction in environmental disease: potential for risk modification and risk reversal. Presented at the Symposium on Assessment and Perception of Health Risk, Royal Society of Canada and the Science Council of Canada, Toronto, Canada, October 18, 1982 (in press).
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Selikoff, I.J. (1984). Investigation of Genetic Hazards: Guidance from Occupational and Environmental Studies. In: de Serres, F.J., Pero, R.W. (eds) Individual Susceptibility to Genotoxic Agents in the Human Population. Environmental Science Research, vol 30. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2765-3_1
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DOI: https://doi.org/10.1007/978-1-4613-2765-3_1
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