Alternative Approaches to Oral Controlled Drug Delivery: Bioadhesives and In-Situ Systems
In order to delay gastrointestinal transit time to achieve once a day oral dosing or to have localized delivery of drug to selected regions of the GI tract, it is necessary to have the drug-delivery system adhere to the mucin/epithelial surface of the GI tract. The present study describes procedures utilizing fluorescent probes, such as pyrene, in cultured epithelial cells to study polymer binding to the mucin-epithelial surface. It is shown that a number of polymers bind very effectively to the cell surface. Anionic polymers with high charge density appear to be preferred as adhesive polymers. Results from this in vitro cell culture study were in rank order agreement with in vivo stomach emptying studies in dogs and precorneal retention in albino rabbits.
KeywordsCysteine Heparin Serine Proline Polypeptide
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