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Critical Reviews in Tropical Medicine pp 77–91Cite as

Oral Rehydration Therapy

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Abstract

Acute diarrheal diseases are among the leading causes of childhood mortality and morbidity in developing countries and contribute significantly to malnutrition. A critical review (Snyder and Merson, 1982) of 27 active surveillance studies conducted for a year or more suggests that about 750 million children below 5 years of age in Asia, Africa, and Latin America suffer from acute diarrhea and between 3 and 6 million of them die annually.

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References

  • Anonymous, 1980a, Oral rehydration therapy (ORT) for childhood diarrhoea, Popul. Rep. 1 (2): 624.

    Google Scholar 

  • Anonymous, 1980b, A manual for the treatment of acute diarrhoea. Document WHO/CDD/ SER/80. 2, World Health Organization, Geneva.

    Google Scholar 

  • Barany, E. H., and Sperber, E., 1939, Absorption of glucose against a concentration gradient by the small intestine of the rabbit, Scand. Arch. Physiol. 81: 290.

    CAS  Google Scholar 

  • Barry, R. J. C., Smyth, D. H., and Wright, E. M., 1965, Short circuit current and solute transfer by rat jejunum, 7. J. Physiol 181: 410–431.

    PubMed  CAS  Google Scholar 

  • Burke, V., Gracey, M., Suharyono, and Sunoto, 1980, Reduction by aspirin of intestinal fluid loss in acute childhood gastroenteritis, Lancet 1: 1329–1330.

    Article  PubMed  CAS  Google Scholar 

  • Carpenter, C. C. J., Sack, R. B., Feeley, J. C., and Steenberg, R. W., 1968, Site and characteristics of electrolyte loss and effects of intraluminal glucose in experimental canine cholera, J. Clin. Invest. 47: 1210–1220.

    Article  PubMed  CAS  Google Scholar 

  • Chatterjee, H. N., 1953, Control of vomiting in cholera and oral replacement of fluid, Lancet 2: 1063.

    Article  Google Scholar 

  • Chatterjee, A., Mahalanabis, D., Jalan, K. N., Maitra, T. K., Agarwal, S. K., Bagchi, D. K., and Indra, S., 1977, Evaluation of a sucrose/electrolyte solution for oral rehydration in acute infantile diarrhoea, Lancet 1: 133–135.

    Google Scholar 

  • Chatterjee, A., Mahalanabis, D., Jalan, K. N., Maitra, T. K., Agarwal, S. K., Dutta, B., Khatua, S. P., and Bagchi, D. K., 1978, Oral rehydration in infantile diarrhoea, Arch. Dis. Child. 54: 284–289.

    Article  Google Scholar 

  • Chen, L. C., Black R. E., Sarder, A. M., Merson, M. M., Bhatia, S., Yonus, M., and Chakraborty, J., 1980, Village-based distribution of oral rehydration therapy packets in Bangladesh, Am. J. Trop. Med. Hyg. 29: 285–290.

    PubMed  CAS  Google Scholar 

  • Chung, A. W., 1948, The effect of oral feeding at different levels on the absorption of foodstuffs in infantile diarrhoea, J. Pediatr. 33: 1–13.

    Article  PubMed  CAS  Google Scholar 

  • Cleary, T. G., Cleary, K. R., Dupont, H. L., El-Maligh, G. S., Kordy, M. I., Mohieldin, M. S., Shoukry, I., Shurky, S., Wyatt, R. G., and Woodward, W. E., 1981, The relationship of oral rehydration solution to hypernatraemia in infantile diarrhoea, J. Pediatr. 99: 739–741.

    Article  PubMed  CAS  Google Scholar 

  • Crane, R. K., 1965. Sodium dependent transport in the intestine and other animal tissues, Fed. Proc. 24: 1000–1006.

    PubMed  CAS  Google Scholar 

  • Czaky, T. Z., 1963, A possible link between active transport of electrolytes and non-electrolytes, Fed. Proc. 22: 3–7.

    Google Scholar 

  • Darrow, D. C., 1946. The retention of electrolyte during recovery from severe dehydration due to diarrhoea, J. Pediatr. 28: 515.

    Article  PubMed  CAS  Google Scholar 

  • Darrow, D. C., Praft, E. L., Flett, J., Jr., Gamble, A. H., and Wiese, H. F., 1949, Disturbances of water and electrolytes in infantile diarrhoea, Pediatrics 3: 129.

    PubMed  CAS  Google Scholar 

  • Fordtran, J. S., 1975, Stimulation of active and passive sodium absorption by sugars in the human jejunum, J. Clin. Invest. 55: 728–737.

    Article  PubMed  CAS  Google Scholar 

  • Fordtran, J. S., and Dietschy, J. M., 1966, Water and electrolyte movement in the intestine, Gastroenterology 50: 263.

    PubMed  CAS  Google Scholar 

  • Fordtran, J. S., Rector, F. C., and Carter, N. W., 1968, The mechanism of sodium absorption in the human small intestine, J. Clin. Invest. 47: 884–900.

    Article  PubMed  CAS  Google Scholar 

  • Hanson, H. E., 1954, The treatment of diarrhea in infancy, Pediatr. Clin. N. Am. 1: 335–348.

    Google Scholar 

  • Hirschhorn, N., 1980, The treatment of acute diarrhea in children: An historical and physiological perspective, Am. J. Clin. Nutr. 33: 637–663.

    PubMed  CAS  Google Scholar 

  • Hirschhorn, H., Kinzie, J. L., Sechar, D. B., Northrup, R. S., Taylor, J. O., Ahmad, S. Z., and Phillips, R. A., 1968, Decrease in net stool output in cholera during intestinal perfusion with glucose containing solutions, N. Engl. J. Med. 279: 176–181.

    Article  PubMed  CAS  Google Scholar 

  • Hirschhorn, N., Cash, R. A., Woodward, W. E., and Spivey, G. H., 1972, Oral fluid therapy of Apache children with acute infectious diarrhoea, Lancet 2: 15.

    Article  PubMed  CAS  Google Scholar 

  • Hirschhorn, N., McCarthy, B. J., Ranney, B., Hirschhorn, M. A., Woodward, S. T., Lacapa, A., Cash, R. A., and Woodward, W. E., 1973, Ad libitum glucose electrolyte therapy for acute diarrhoea in Apache children, J. Pediatr. 83: 562–571.

    Article  PubMed  CAS  Google Scholar 

  • Hirschhorn, N., and Denny, K. M., 1975, Oral glucose electrolyte therapy for diarrhea a means to maintain or improve nutrition? Am. J. Clin. Nutr. 28: 189–192.

    PubMed  CAS  Google Scholar 

  • Kielmann, A. A., and McCord, C., 1977, Home treatment of childhood diarrhoea in Punjab villages, Environmental Child Health 23 (4): 197–201.

    PubMed  CAS  Google Scholar 

  • Levinson, R. A., and Schedl, H. P., 1966, Absorption of sodium, chloride, water, and simple sugars in rat small intestine, Am. J. Physiol. 211: 939–942.

    PubMed  CAS  Google Scholar 

  • Mahalanabis, D., 1981a, Nitrogen balance during recovery from secretory diarrhea of cholera in children, Am. J. Clin. Nutr. 34: 1548–1551.

    PubMed  CAS  Google Scholar 

  • Mahalanabis, D., 1981b, Rehydration therapy in diarrhoea, in: Acute Enteric Infections in Children: New Prospects in Treatment & Prevention (T. Holme, J. Holmgren, M. H. Merson, and R. Mollby, eds. ), Elsevier-North Holland, pp. 303–318.

    Google Scholar 

  • Mahalanabis, D., and Patra, F. C., 1983, In search of a super oral rehydration solution: Can optimum use of organic solute mediated sodium absorption lead to the development of an absorption promoting drug? J. Diarrh. Dis. Res. 1: 76–81.

    CAS  Google Scholar 

  • Mahalanabis, D., Wallace, C. K., Kallen, R. J., Mondal, A., and Pierce, N. F., 1970, Water and electrolyte losses due to cholera in infants and small children: A recovery balance study, Pediatrics 45: 374.

    PubMed  CAS  Google Scholar 

  • Mahalanabis, D., Chowdhury, A. B., Bagchi, N. G., Bhattacharya, A. K., and Simpson, T. W., 1973, Oral fluid therapy of cholera among Bangladesh refugees, Johns Hopkins Med. J. 132 (4): 197–205.

    PubMed  CAS  Google Scholar 

  • Mahalanabis, D., Sack, R. B., Jacobs, B., Mondal, A., and Thomas, J., 1974, Use of an oral glucose electrolyte solution in the treatment of pediatric cholera: A controlled study, J. Trop. Pediatr. Environ. Child Health 20 (2): 82–87.

    PubMed  CAS  Google Scholar 

  • Mahalanabis, D., Merson, M. H., and Barua, D., 1981, Oral rehydration therapy—recent advances, World Health Forum 2 (2): 245–249.

    Google Scholar 

  • Malawar, S. J., Enton, M., Fordtran, J. S., and Ingelfinger, F. J., 1965, Interrelation between jejunal absorption of sodium glucose and water in man, abstract, J. Clin. Invest. 44 (6): 1072.

    Article  Google Scholar 

  • Molla, A. M., Sarkar, S. A., Hossain, M., Molla, A., and Greenough, W. B., Ill, 1982, Rice powder electrolyte solution as oral therapy in diarrhoea due to Vibrio cholerae and Escherichia coli, Lancet 1: 1317–1319.

    Article  PubMed  CAS  Google Scholar 

  • Nalin, D. R., and Cash, R. A., 1970. Oral or nasogastric maintenance therapy for diarrhea of unknown aetiology resembling cholera, Trans. Roy. Soc. Trop. Med. Hyg. 64: 769–771.

    Article  PubMed  CAS  Google Scholar 

  • Nalin, D. R., Cash, R. A., Islam, R., Molla, M., and Phillips, R. A., 1968, Oral maintenance therapy for cholera in adults, Lancet 2: 370–373.

    Article  PubMed  CAS  Google Scholar 

  • Nalin, D. R., Levine, M. M.,Mata, L., de Cespedes, C., Vargas, W., Lizano, C., Loria, A. R., Simhon, A. and Mohs, E., 1978, Comparison of sucrose with glucose in oral therapy of infant diarrhoea, Lancet 2: 277–279.

    Article  PubMed  CAS  Google Scholar 

  • Nalin, D. R., Levine, M. M., Mata, L., de Cespedes, C., Vargas,W., Lizano, C., Loria, A. R., Simhon, A., and Mohs, E., 1979, Oral rehydration and maintenance of children with rotavirus and bacterial diarrhoea, Bull. W.H.O. 57: 453–459.

    PubMed  CAS  Google Scholar 

  • Nalin, D. R., Harland, E., Ramlal, A., Swaby, D., McDonald, J., Gangarosa, R., Levine, M., Akierman, A., Antoinee, M., Mackenzie, K., and Johnson, B., 1980. Comparison of low and high sodium and potassium content in oral rehydration solution, J. Pediatr. 97: 848–853.

    Article  PubMed  CAS  Google Scholar 

  • Palmer, D. K., Kostar, F. T., Islam, A. F. M. R., Rahman, A. S. M. M., and Sack, R. B., 1977, Comparison of sucrose and glucose in the oral electrolyte therapy of cholera and other severe diarrhoea, N. Engl. J. Med. 297: 1107–1110.

    Article  PubMed  CAS  Google Scholar 

  • Patra, F. C., Mahalanabis, D., and Jalan, K. N., 1982a, Stimulation of sodium and water absorption by sucrose in the rat small intestine, Acta Pediatr. Scand. 71: 103–107.

    Article  CAS  Google Scholar 

  • Patra, F. C., Mahalanabis, D., Jalan, K. N., Sen, A., and Banerjee, P., 1982b, Can acetate replace bicarbonate in oral rehydration solution for infantile diarrhoea? Arch. Dis. Child 57: 625–627.

    Article  PubMed  CAS  Google Scholar 

  • Patra, F. C., Mahalanabis, D., Jalan, K. N., Sen, A., and Banerjee, P., 1982c, Is rice electrolyte solution superior to glucose electrolyte solution in infantile diarrhoea? Arch. Dis. Child 57:910–912.

    Article  CAS  Google Scholar 

  • Phillips, R. A., 1964, Water and electrolyte losses in cholera, Fed. Proc. 23: 705–712.

    PubMed  CAS  Google Scholar 

  • Pierce, N. F., Banwell, J. G., Mitra, R. C., Caranos, G. J., Keimowitz, R. I., Mondal, A., and Manji, P. M., 1968a, Oral maintenance of water-electrolyte and acid-base balance in cholera, a preliminary report, Ind. J. Med. Res. 56: 640–645.

    CAS  Google Scholar 

  • Pierce, N. F., Banwell, J. G., Mitra, R. C., Caransos, G. J., Keimowitz, R. I., Mondal, A., and Manji, P. M., 1968b, Effect of intragastric glucose electrolyte infusion upon water and electrolyte balance in Asiatic cholera, Gastroenterology 55: 333–343.

    PubMed  CAS  Google Scholar 

  • Pierce, N. F., Sack, R. B., Mitra, R. C., Banwell, J. G., Brigham, K. L., Fedson, D. S., and Mondal, A., 1969, Replacement of water electrolyte losses in cholera by an oral glucose- electrolyte solution, Ann. Int. Med. 70: 1173.

    PubMed  CAS  Google Scholar 

  • Pizarro, D., Posada, G., Mata, L., Nalin, D., and Mohs, E., 1979a, Oral rehydration of neonates with dehydrating diarrhoeas, Lancet 2: 1209.

    Article  PubMed  CAS  Google Scholar 

  • Pizarro, D., Posada, G., Mohs, E., Levine, M. M., and Balin, D. R., 1979b. Evaluation of oral therapy for infant diarrhoea in an emergency room setting: The acute episode as an opportunity for instructing mothers in home treatment, Bull. W.H.O. 57: 983–986.

    PubMed  CAS  Google Scholar 

  • Pizarro, D., Posada, G., and Mata, L., 1983, Treatment of 242 neonates with dehydrating diarrhoea with an oral glucose-electrolyte solution, J. Pediatr. 102: 153–156.

    Article  PubMed  CAS  Google Scholar 

  • Rabbini, G. H., Greenough, W. B., Holmgren, J., and Lonroth, L., 1979, Chlorpromazine reduces fluid loss in cholera, Lancet 1: 410.

    Article  Google Scholar 

  • Rahman, M. M., Aziz, K. M. S., Patwariy, and Munhi, M. H., 1979, Diarrhoeal mortality in the Bangladeshi villages with and without community based oral rehydration therapy, Lancet 2: 809–812.

    Google Scholar 

  • Reid, E. W., 1902, Intestinal absorption of solutions, J. Physiol. [London] 28: 241.

    PubMed  CAS  Google Scholar 

  • Riklis, E., and Quastel, J. H., 1958, Effects of cations on sugar absorption by isolated surviving guinea pig intestine, Can. J. Biochem. Physiol. 36: 347–362.

    Article  PubMed  CAS  Google Scholar 

  • Rosenfield, W., DeRomano, G. L., Jleinman, R., and Finberg, L., 1977, Improving the clinical management of hypernatremic dehydration: Observations from a study of 67 infants with this disorder, Clin. Pediatr. 16: 411.

    Article  Google Scholar 

  • Sack, D. A., Chowdhury, A. M. A. K., Eusof, A., Ali, M. A., Merson, M. H., Islam S., Black, R. E., and Brown, K. H., 1978, Oral hydration in rotavirus diarrhoea: A double blind comparison of sucrose with glucose electrolyte solution, Lancet 2: 280.

    Article  PubMed  CAS  Google Scholar 

  • Sack, D. A., Islam, A., Holmgren, J., and Svennerhalm, A., 1980a, Development of methods for determining the intestinal immune response to Vibrio cholera antigens in humans in: Proceeding of the XV Joint Conference on Cholera, Bethesda, Maryland, pp. 423–439.

    Google Scholar 

  • Sack, D. A., Islam, S., Brown, K. H., Islam, A., Kabir, A. K. M. I., Chowdhury, A. M. A. K., and Ali, M. A., 1980b, Oral therapy in children with cholera: A comparison of sucrose and glucose electrolyte solution, J. Pediatr. 96: 20–25.

    Article  PubMed  CAS  Google Scholar 

  • Sack, D. A., Islam, S., Merson, M. H., Brown, K. H., Black, R. E., Rahman, M., Chowdhury, M. A. K. A., and Ali, M. A., 1979, Sucrose or glucose—which sugar to use in oral rehydration solution: A summary of four clinical trials, in: Symposium on Cholera (K. Takeya and Y. Zinnaka, eds.), Karatsu, Japan, 1978 ( Proceedings of the Fourteenth Joint Conference, U.S.-Japan Co-operative Medical Science Program, Cholera Panel), Japanese Cholera Panel, Tokyo, pp. 154–164.

    Google Scholar 

  • Sandhu, B. K., Jones, B. J. M., Brook C. G. D., and Silk, D. B. A., 1982, Oral rehydration in acute infantile diarrhoea with a glucose-polymer electrolyte solution, Arch. Dis. Child 57: 152–154.

    Article  PubMed  CAS  Google Scholar 

  • Schedl, H. P., and Clifton, J. A., 1963, Solute and water absorption by the human small intestine, Nature [London] 199: 1264–1267.

    Article  CAS  Google Scholar 

  • Schultz, S. C., 1977, Sodium-coupled solute transport by small intestine: A status report, Am. J. Physiol. 223: E249–254.

    Google Scholar 

  • Schultz, S. C., and Zalusky, R., 1964, Ion transport in isolated rabbit ileum: II. The interaction between active sodium and active sugar transport, J. Gen. Physiol. 47: 1043–1059.

    Article  PubMed  CAS  Google Scholar 

  • Sladen, G. F., and Dawson, A. M., 1969, Interrelationships between the absorption of glucose, sodium and water by the normal human jejunum, Clin. Sci. 36: 119–132.

    PubMed  CAS  Google Scholar 

  • Snyder, J. D., and Merson, M. H., 1982, The magnitude of global problem of acute diarrhoeal disease: Review of active surveillance data, Bull. W.H.O. 6: 605–614.

    Google Scholar 

  • Taylor, J. O., Kinzie, J., Hare, R., and Hare, K., 1968, Measurement of sodium flexure in human small intestine, abstract 0964, J. Clin. Invest. 27: 386.

    Google Scholar 

  • Turnberg, L. A., Bieberdorf, F. A., Morawski, S. G., and Fordtran, J. S., 1970a, Interrelationships of chloride, bicarbonate, sodium and hydrogen transport in the human ileum, J. Clin. Invest. 49: 557–567.

    Article  PubMed  CAS  Google Scholar 

  • Turnberg, L. A., Fordtran, J. S., Carter, N. W., and Rector, F. C., Jr., 1970b, Mechanisms of bicarbonate absorption and its relationship to sodium transport in the human jejunum. J. Clin. Invest. 49: 548–556.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Kothari Centre of Gastroenterology, The Calcutta Medical Research Institute, Calcutta, 700027, India

    Dilip Mahalanabis

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  1. Dilip Mahalanabis
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Editors and Affiliations

  1. Memorial University of Newfoundland, St. John’s, Newfoundland, Canada

    R. K. Chandra

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© 1984 Plenum Press, New York

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Mahalanabis, D. (1984). Oral Rehydration Therapy. In: Chandra, R.K. (eds) Critical Reviews in Tropical Medicine. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2723-3_3

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  • DOI: https://doi.org/10.1007/978-1-4613-2723-3_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9689-8

  • Online ISBN: 978-1-4613-2723-3

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